Results 21 to 30 of about 39,485 (293)

G-Quadruplex Structures and G-Quadruplex-Interactive Compounds [PDF]

, 2011
G-quadruplexes are noncanonical secondary structures formed in DNA sequences containing consecutive runs of guanines. DNA G-quadruplexes have recently emerged as attractive cancer therapeutic targets. It has been shown that the 3' G-rich single-stranded overhangs of human telomeres can form G-quadruplex structures.
Raveendra I, Mathad, Danzhou, Yang
openaire   +2 more sources

Activity of Human Apurinic/Apyrimidinic Endonuclease APE1 Toward Damaged DNA and Native RNA With Non-canonical Structures

Frontiers in Cell and Developmental Biology, 2020
The primary role of apurinic/apyrimidinic (AP) endonuclease APE1 in human cells is the cleavage of the sugar phosphate backbone 5′ to an AP site in DNA to produce a single-strand break with a 5′-deoxyribose phosphate and 3′-hydroxyl end groups.
Anastasia T. Davletgildeeva, Anastasia T. Davletgildeeva, Alexandra A. Kuznetsova, Olga S. Fedorova, Nikita A. Kuznetsov   +4 more
doaj   +1 more source

Why are G-quadruplexes good at preventing protein aggregation?

RNA Biology, 2023
Maintaining a healthy protein folding environment is essential for cellular function. Recently, we found that nucleic acids, G-quadruplexes in particular, are potent chaperones for preventing protein aggregation.
Theodore J. Litberg, Rajesh Kumar Reddy Sannapureddi, Zijue Huang, Ahyun Son, Bharathwaj Sathyamoorthy, Scott Horowitz   +5 more
doaj   +1 more source

Non-G Base Tetrads

Molecules, 2022
Tetrads (or quartets) are arrangements of four nucleobases commonly involved in the stability of four-stranded nucleic acids structures. Four-stranded or quadruplex structures have attracted enormous attention in the last few years, being the most ...
Núria Escaja, Bartomeu Mir, Miguel Garavís, Carlos González   +3 more
doaj   +1 more source

Identification of G-quadruplex DNA/RNA binders: Structure-based virtual screening and biophysical characterization [PDF]

, 2017
Background Recent findings demonstrated that, in mammalian cells, telomere DNA (Tel) is transcribed into telomeric repeat-containing RNA (TERRA), which is involved in fundamental biological processes, thus representing a promising anticancer target. For
Alcaro, Stefano, Artese, Anna, Costa, Giosu\ue8, Distinto, Simona, Maccioni, Elias, Moraca, Federica, Nadai, Matteo, Ortuso, Francesco, Richter, Sara, Rocca, Roberta, Scalabrin, Matteo, Talarico, Carmine   +11 more
core   +1 more source

Transition Mutations in the hTERT Promoter Are Unrelated to Potential i-motif Formation in the C-Rich Strand

Biomolecules, 2023
Increased expression of the human telomere reverse transcriptase (hTERT) in tumors promotes tumor cell survival and diminishes the survival of patients.
James W. Conrad, Mark L. Sowers, Dianne Y. Yap, Ellie Cherryhomes, B. Montgomery Pettitt, Kamil Khanipov, Lawrence C. Sowers   +6 more
doaj   +1 more source

G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy [PDF]

, 2018
G-quadruplexes (G4s) are non-canonical nucleic acids secondary structures that form within guanine-rich strands of regulatory genomic regions. G4s have been extensively described in the human genome, especially in telomeres and oncogene promoters; in ...
Richter, Sara N, Ruggiero, Emanuela
core   +1 more source

Formation of a Unique Cluster of G-Quadruplex Structures in the HIV-1 nef Coding Region: Implications for Antiviral Activity [PDF]

, 2013
G-quadruplexes are tetraplex structures of nucleic acids that can form in G-rich sequences. Their presence and functional role have been established in telomeres, oncogene promoters and coding regions of the human chromosome.
Frasson, Ilaria, Nadai, Matteo, Palumbo, Manlio, Palù, Giorgio, Perrone, Rosalba, Poe, Jerrod A., Qiu, Jianming, Richter, Sara N., Smithgall, Thomas E.   +8 more
core   +2 more sources

Structure and possible function of a G-quadruplex in the long terminal repeat of the proviral HIV-1 genome [PDF]

, 2016
open8The long terminal repeat (LTR) of the proviral human immunodeficiency virus (HIV)-1 genome is integral to virus transcription and host cell infection.

core   +1 more source

GW-2974 and SCH-442416 modulators of tyrosine kinase and adenosine receptors can also stabilize human telomeric G-quadruplex DNA.

PLoS ONE, 2022
GW-2974 is a potent tyrosine kinase receptor inhibitor while SCH-442416 is a potent adenosine receptors' antagonist with high selectivity towards human adenosine A2A receptor over other adenosine receptors. The two compounds were reported to possess anti-
Alaa A Salem, Ismail A El Haty, Mohammad A Ghattas   +2 more
doaj   +2 more sources