Results 21 to 30 of about 2,816 (159)

Fourth-Generation QuantiFERON-TB Gold Plus: What Is the Evidence? [PDF]

Journal of Clinical Microbiology, 2020
QuantiFERON-TB Gold Plus (QFT-Plus) is the latest generation of interferon gamma release assays (IGRAs) to receive approval from the U.S. FDA, replacing its predecessor, QuantiFERON-TB Gold In-Tube (QFT-GIT). The novelty of QFT-Plus is that it elicits a response from CD8 T cells, in addition to CD4 T cells, thus collecting a broader response from T ...
Catherine A Hogan, Madhukar Pai, Niaz Banaei   +2 more
exaly   +5 more sources

First evaluation of QuantiFERON-TB Gold Plus performance in contact screening [PDF]

European Respiratory Journal, 2016
Identifying latently infected individuals is crucial for the elimination of tuberculosis (TB). We evaluated for the first time the performance of a new type of interferon-γ release assay, QuantiFERON-TB Plus (QFT-Plus), which includes an additional antigen tube (TB2), stimulating both CD4+and CD8+T-cells in contacts of TB patients.Contacts were ...
Barcellini, Lucia, Borroni, Emanuele, Brown, James, Brunetti, Enrico, Campisi, Daniela, Castellotti, Paola F., Codecasa, Luigi R., Cugnata, Federica, Di Serio, Clelia, Ferrarese, Maurizio, Goletti, Delia, Lipman, Marc, Rancoita, Paola Maria Vittoria, Russo, Giulia, Tadolini, Marina, Vanino, Elisa, Cirillo, Daniela M.   +16 more
core   +9 more sources

Comparing the performance of QuantiFERON-TB Gold Plus with QuantiFERON-TB Gold in-tube among highly TB exposed gold miners in South Africa [PDF]

Gates Open Research, 2021
Background: QuantiFERON-TB-Gold-in-tube (QFT-GIT) is an interferon-gamma release assay (IGRA) used to diagnose latent tuberculosis infection. Limited data exists on performance of QuantiFERON-TB Gold-Plus (QFT-Plus), a next generation of IGRA that includes an additional antigen tube 2 (TB2) while excluding TB7.7
Thobani Ntshiqa, Violet Chihota, Raoul Mansukhani, Lindiwe Nhlangulela, Kavindhran Velen, Salome Charalambous, Pholo Maenetje, Thomas R. Hawn, Robert Wallis, Alison D. Grant, Katherine Fielding, Gavin Churchyard   +11 more
openaire   +3 more sources

Comparative Results of QuantiFERON-TB Gold In-Tube and QuantiFERON-TB Gold Plus Assays for Detection of Tuberculosis Infection in Clinical Samples

Journal of Clinical Microbiology, 2020
The QuantiFERON-TB Gold plus (QFT-Plus) assay, an interferon gamma (IFN-γ) release assay (IGRA), was recently introduced as the next version of the QuantiFERON-TB Gold In-Tube (QFT-GIT) assay for diagnosing latent tuberculosis (TB). Whereas the QFT-GIT assay uses only one TB tube that induces a cell-mediated immune (CMI) response of CD4
Dongju Won, Jung Yong Park, Hyon-Suk Kim, Younhee Park   +3 more
openaire   +5 more sources

Comparative evaluation of QuantiFERON-TB gold in-tube plus for Mycobacterium tuberculosis infection among adolescents in China

BMC Public Health
Summary To our knowledge, this is the first head-to-head study to evaluate QuantiFERON-TB Gold Plus, QuantiFERON-TB Gold In-Tube, ESAT6-CFP10, and tuberculin skin test among adolescents.
Peng Lu, Leonardo Martinez, Hao Xue, Qiao Liu, Xiaoyan Ding, Jingjing Pan, Hui Ding, Wei Lu, Limei Zhu, Jiangming Wang   +9 more
doaj   +2 more sources

Evaluation of QuantiFERON TB gold plus among TB household contacts in high incidence settings [PDF]

BMC Infectious Diseases
Background Accurately identifying and categorizing individuals who are latently infected is critical for developing prevention strategies against tuberculosis (TB) disease.
Sophie Nalukwago, Bonnie Thiel, Keith Chervenak, AnnaRitah Namuganga, LaShaunda L. Malone, Mary Nsereko, W. Henry Boom, Harriet Mayanja-Kizza   +7 more
doaj   +2 more sources

Standard E TB-Feron ELISA and Standard F TB-Feron FIA positivity rates and agreement with QuantiFERON-TB Gold Plus among TB high-risk population in Bandung, Indonesia [PDF]

Journal of Clinical Microbiology
Tuberculosis (TB) remains a global public health problem. The determination of tuberculosis infection (TBI) using interferon-gamma release assay has now been used widely.
Dewi Kartika Turbawaty, Syifa Nur Maulida, Darin Rizka Anadhea, Mulyanusa Amarullah Ritonga, Basti Andriyoko, Rudi Wisaksana, Agnes Rengga Indrati, Nanny Natalia Mulyani Soetedjo, Laniyati Hamijoyo, Raspati Cundarani Koesoemadinata, Bachti Alisjahbana, Ida Parwati   +11 more
doaj   +2 more sources

Performance of QuantiFERON-TB Gold Plus assays in paediatric tuberculosis: a multicentre PTBNET study

Thorax, 2022
RationaleIn 2016, a new interferon-gamma release assay (IGRA) was introduced, QuantiFERON-TB Gold Plus (QFT-Plus), claimed to have improved sensitivity in active tuberculosis (TB).ObjectivesThis study aimed to determine the performance of QFT-Plus, compared with previous generation IGRAs and the tuberculin skin test (TST), in children with TB in Europe.
Buonsenso, Danilo, Noguera-Julian, Antoni, Moroni, Rossana, Hernández-Bartolomé, Angel, Fritschi, Nora, Lancella, Laura, Cursi, Laura, Soler-Garcia, Aleix, Krüger, Renate, Feiterna-Sperling, Cornelia, Sali, Michela, Lo Vecchio, Andrea, Scarano, Sara, Hernanz Lobo, Alicia, Espiau, Maria, Soriano-Arandes, Antonio, Cetin, Benhur Sirvan, Brinkmann, Folke, Ozere, Iveta, Baquero-Artigao, Fernando, Tsolia, Maria, Milheiro Silva, Tiago, Bustillo-Alonso, Matilde, Martín Nalda, Andrea, Mancini, Margherita, Starshinova, Anna, Ritz, Nicole, Velizarova, Svetlana, Ferreras-Antolín, Laura, Götzinger, Florian, Bilogortseva, Olga, Chechenyeva, Vira, Tebruegge, Marc, Santiago-García, Begoña, Ptbnet QFT-Plus study group   +34 more
openaire   +8 more sources

Discordance of 3rd and 4th generation QuantiFERON-TB Gold assays by pregnancy stages in India

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
Background: Pregnancy and HIV affect CD4+ T lymphocytes and impact performance of QuantiFERON-TB Gold (QFT). We compared the results of QFT with QuantiFERON-TB Gold Plus (QFT-Plus), which also measures CD8+ responses to TB antigens, during pregnancy and ...
Vandana Kulkarni, Mallika Alexander, Ramesh Bhosale, Divyashri Jain, Prasad Deshpande, Emily Shira Gitlin, Arthi Vaidyanathan, Andrea Chalem, Shilpa Naik, Nikhil Gupte, Neelu Nawani, Amita Gupta, Jyoti Mathad   +12 more
doaj   +2 more sources

Sensitivity and characteristics associated with positive QuantiFERON-TB Gold-Plus assay in children with confirmed tuberculosis.

PLoS ONE, 2019
BACKGROUND:Although QuantiFERON-TB Gold Plus (QFT-Plus), a new interferon-gamma release assay, has shown good performance in adults, little data is available in children. METHODS:De-identified data from TB-suspected patients age
Duc T Nguyen, Ha Phan, Trang Trinh, Hang Nguyen, Ha Doan, Nam Pham, Hung Nguyen, Hanh Nguyen, Hung V Nguyen, Hoi V Le, Nhung Nguyen, Edward A Graviss   +11 more
doaj   +2 more sources