Results 181 to 190 of about 265,123 (216)

DEET‐cyclodextrin inclusion complexes for mosquito and tick repellency: Extended repellency time and no zebrafish embryotoxicity

Pest Management Science, EarlyView.
Hydroxypropyl‐β‐cyclodextrin (HPβCD)–N,N‐diethyl‐meta‐toluamide (DEET) complex extended tick repellency to 168 h. Full protection against Aedes aegypti for 7 h with HPβCD‐DEET. HPβCD reduced DEET release and skin retention significantly. No embryotoxicity observed below 325 mg L−1 in zebrafish model.
Gessyka Rayana Silva Pereira, Gleidson Cardoso, Maria Luiza Kuhn Camargo, Michele Resende Machado, Mayara Macedo Barrozo, Juscelino Rodrigues, Gisele Augusto Rodrigues de Oliveira, Caio Monteiro, Christian Luz, Ricardo Neves Marreto, Stephânia Fleury Taveira   +10 more
wiley   +1 more source

Antisense oligonucleotide allele-specific targeting of EFEMP1 in a patient-derived model of Doyne honeycomb retinal dystrophy. [PDF]

Mol Ther Nucleic Acids
Rezek FO, Sanchez-Pintado B, Eden ER, Corral-Serrano JC, Aychoua N, Webster AR, de Guimarães TAC, Carr AF, Michaelides M, Cheetham ME, van der Spuy J.   +10 more
europepmc   +1 more source

Analysis of C4 Concentrations to Predict Impact of Patient‐Reported Diarrhea Associated With the Ileal Bile Acid Transporter Inhibitor Linerixibat

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 596-605, March 2025.
ABSTRACT Linerixibat, an ileal bile acid transporter (IBAT) inhibitor, is being evaluated for the treatment of pruritus in primary biliary cholangitis (PBC). Diarrhea is commonly reported with this drug class as IBAT inhibition redirects bile acids (BA) to the colon.
Fernando Carreño, Rashmi Mehta, Andrea Ribeiro de Souza, Jon Collins, Brandon Swift   +4 more
wiley   +1 more source

Chromosome fusion enhances dependency on Rif1 for entanglement resolution during meiosis in S. pombe. [PDF]

Commun Biol
Zhou Y, Wei X, Zhang J, Gu X, Gong W, Zhou J, Li W, He X.   +7 more
europepmc   +1 more source

Baicalein Sensitizes Radioresistant BT549 and MCF7‐R Breast Cancer Cells by Modulating Rac1 Signaling

Phytotherapy Research, EarlyView.
ABSTRACT Radioresistance remains a key barrier in breast cancer (BC) treatment. Baicalein, a flavonoid from Scutellaria baicalensis, has shown potential to enhance radiosensitivity. This study investigates its efficacy and mechanism in radioresistant BC models. Radioresistant BC cell models were established via fractionated irradiation and validated by
Zitong Zhao, Zhangyun Li, Quanzhou Peng, Shuqun Zhang   +3 more
wiley   +1 more source

Targeted and Nontargeted Detection and Quantitation of Arsenolipids in a Tuna Fish Reference Material (BCR-627) Using Reversed-Phase HPLC with High-Resolution Electrospray Mass Spectrometry and Inductively Coupled Plasma Mass Spectrometry. [PDF]

Anal Chem
Kapsi M, Stergiou E, Drakonaki C, Marmatakis K, Panagou G, Kalantzi I, Tsapakis M, Pergantis SA.   +7 more
europepmc   +1 more source

Mammalian Osteoderm Ultrastructure in the Armored Acomys Spiny Mouse Tail

Small, EarlyView.
The ultrastructure of armored platelets – termed osteoderms – in the tail skin of Acomys cahirinus spiny mice is characterized using 2D and 3D microscopy methods. The imbricated structure is composed of calcium phosphate biomineral and has select structural elements that are bone‐like and tooth‐like in nature.
Joseph Deering, Malcolm Maden, Marc D. McKee   +2 more
wiley   +1 more source

Acarbose modulates microglial Pkm2 acetylation to reshape immunometabolism and preserve retinal neurons after ischemia-reperfusion. [PDF]

J Neuroinflammation
Wen Y, Dou YN, Chen X, Liu X, Yang Z, Zhu Y, Li Z, Deng C, Deng Y, Su W, Zhuo Y.   +10 more
europepmc   +1 more source

Accurate Sizing and Resolution of Nominal 200 nm Diameter Polystyrene Nanospheres With Charge Detection Mass Spectrometry

Small, EarlyView.
This study highlights the utility of charge detection mass spectrometry (CDMS) as a high‐throughput nanoparticle characterization tool. CDMS measurements of 200 nm polystyrene size standards are within 1% of those derived from transmission electron microscopy (TEM). Notably, a mixture of three ∼200 nm samples is readily resolved by CDMS but not by TEM,
Veena S. Avadhani, Conner C. Harper, Evan R. Williams   +2 more
wiley   +1 more source