Results 161 to 170 of about 265,123 (216)

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source

Recommendations and considerations for hydroxyl radical protein footprinting-mass spectrometry. [PDF]

Nat Methods
Wecksler AT, Wang L, Bernstein LJ, Huang RY, Gupta S, Kristensen LG, Ralston CY, Sobott F, Sun Y, Brenowitz M, Farquhar ER, Chance MR, Kuang XC, Gross ML, Jones LM, Novak P, Misra SK, Sharp JS.   +17 more
europepmc   +1 more source

LKB1 Loss Sensitizes Lung Tumor Spheres to Mitomet‐Induced Ferroptosis, and These Effects are Enhanced by mTOR Inhibition

Molecular Carcinogenesis, EarlyView.
ABSTRACT Owing to their robust antioxidant defense mechanisms, cancer stem‐like cells (CSCs) maintain a low level of oxidative stress, which is crucial for preserving stemness and pluripotency. Therefore, agents that either directly generate reactive oxygen species (ROS) or inhibit the antioxidant defense systems can selectively induce oxidative cell ...
Xueqing Liang, Ali Nakhi, Peter I. Dosa, Gunda I. Georg, Fekadu Kassie   +4 more
wiley   +1 more source

Differential Thermal Inactivation Enables Simultaneous Quantitation of Ricin and Abrin. [PDF]

Toxins (Basel)
Jeong WH.
europepmc   +1 more source

Prevention of Myc‐Driven Prostate Cancer in Mice by Oral Administration of Sulforaphane

Molecular Carcinogenesis, EarlyView.
ABSTRACT Prevention is desirable to reduce suffering and death from prostate cancer. However, a clinical‐grade intervention for the prevention of this malignancy is still lacking. This study was undertaken to determine the feasibility of prostate cancer prevention by broccoli constituent sulforaphane (SFN) because epidemiological studies have suggested
Krishna B. Singh, Eun‐Ryeong Hahm, Bruce L. Jacobs, Shivendra V. Singh   +3 more
wiley   +1 more source

<i>Vibrio parahaemolyticus</i> quorum sensing controls phage VP882 transmission. [PDF]

mBio
Sargen MR, Bassler BL.
europepmc   +1 more source

Biomarkers of Leucine‐Rich Repeat Kinase 2 (LRRK2) and Lysosomal Dysfunction in Progressive Supranuclear Palsy

Movement Disorders, EarlyView.
Abstract Background Common and rare genetic variants in leucine‐rich repeat kinase 2 (LRRK2) have been linked with sporadic and familial Parkinson's disease (PD). Recently, we discovered that common genetic variation near the LRRK2 locus determined survival in progressive supranuclear palsy (PSP).
Louise‐Kristine Nielsen, Joshua L.I. Frost, David P. Vaughan, Raquel Real, Riona Fumi, Marte Theilmann Jensen, Megan Hodgson, Eleanor J. Stafford, Lesley Wu, Olaf Ansorge, Annelies Quaegebeur, Kieren S.J. Allinson, Thomas T. Warner, Zane Jaunmuktane, Anjum Misbahuddin, P. Nigel Leigh, Boyd C.P. Ghosh, Kailash P. Bhatia, Alistair Church, Christopher Kobylecki, Michele T.M. Hu, James B. Rowe, Alan A. Shomo, Danielle L. Graham, Omar S. Mabrouk, Huw R. Morris, Esther M. Sammler, Edwin Jabbari   +27 more
wiley   +1 more source

HNF4A P2 isoform alleviates kidney fibrosis by inhibiting dedifferentiation of proximal tubular cells through JAG1/NOTCH signaling. [PDF]

Cell Mol Biol Lett
Jiang G, Lu X, Cao R, Zhang H, Gao Y, Lu K, Zhang L, Zhang G, Wu J, Xu B, Zhong J, Sun J, Chen M, Chen S.   +13 more
europepmc   +1 more source

Rapid and quantitative phage susceptibility test by ramanome

mLife, EarlyView.
Abstract Antimicrobial resistance poses an escalating global threat, renewing interest in bacteriophage therapy as a precision alternative to antibiotics. However, clinical translation remains hindered by the lack of rapid and quantitative phage susceptibility testing (PST) platforms capable of evaluating host range, infection potency, and effective ...
Xiao Han, Xiaofu Wan, Yang Zhou, Xiaoting Fu, Xiaoshan Zheng, Bo Gao, Shi Huang, Anle Ge, Jiadong Huang, Hongzhou Lu, Jian Xu   +10 more
wiley   +1 more source

Benzalkonium Chloride-Induced Nephrotoxicity in 2D Cultures and a Human Kidney-on-a-Chip System. [PDF]

Environ Sci Technol
Brzoska MN, Seguin RP, MacDonald JW, Yang J, Lopez VA, Arnzen S, Kelly EJ, Xu L.   +7 more
europepmc   +1 more source