Results 81 to 90 of about 20,185 (216)

Longevity Humans Have Youthful Erythrocyte Function and Metabolic Signatures

Aging Cell, Volume 24, Issue 5, May 2025.
Longevity humans have “a youthful erythrocyte function and metabolism” with a youth‐like oxygen release and anti‐oxidative capability to combat tissue hypoxia and improve healthspan. ABSTRACT Longevity individuals have lower susceptibility to chronic hypoxia, inflammation, oxidative stress, and aging‐related diseases.
Fang Yu, Changhan Chen, Wuping Liu, Zhixiang Zhao, Yuhua Fan, Zhenjiang Li, Weilun Huang, Tingting Xie, Cheng Luo, Zhouzhou Yao, Qi Guo, Zhiyu Yang, Juan Liu, Yujin Zhang, Rodney E. Kellems, Jian Xia, Ji Li, Yang Xia   +17 more
wiley   +1 more source

Motor Dexterity Deficits in Individuals With First‐Episode Psychosis and Their First‐Degree Relatives

Acta Psychiatrica Scandinavica, EarlyView.
ABSTRACT Introduction Motor dexterity deficits have been observed both before and during first‐episode psychosis (FEP), suggesting this may be a potential endophenotype for schizophrenia spectrum disorders. We aimed to compare motor dexterity performance in FEP patients, their first‐degree relatives, and controls.
Manuel Sevilla‐Ramos, Valentina Ladera, Ricardo García‐García, Rosa Ayesa‐Arriola   +3 more
wiley   +1 more source

Disentangling the Contributions to Phenotypic Change in Conservation Breeding: A Case Study in a Breeding Program of an Endangered Migratory Songbird

Animal Conservation, EarlyView.
Our study uses quantitative genetic modeling to investigate morphological changes in a captive population of endangered Eastern loggerhead shrikes to understand the drivers of phenotypic change in a conservation breeding program. Results suggest that while some evolutionary change has occurred in the breeding population, it is likely driven by genetic ...
Drew Sauve, Dominique Charland, Alisa Solecki, Jane Hudecki, Hazel Wheeler, Hana Thompson, Jessica Steiner, Vicki L. Friesen, Amy A. Chabot   +8 more
wiley   +1 more source

Endophenotype-Informed Association Analyses for Liver Fat Accumulation and Metabolic Dysfunction in the Fels Longitudinal Study. [PDF]

Int J Mol Sci
Garza AL, Blangero J, Lee M, Bauer CX, Czerwinski SA, Choh AC.   +5 more
europepmc   +1 more source

A historical perspective on Lionel Penrose: Scientist, geneticist and dedicated opponent of eugenics

Annals of Human Genetics, EarlyView.
Abstract The paper explores Lionel Penrose's scientific work. Penrose investigated the causes of mental disorders from clinical and genetic points of view. His investigations on phenylketonuria and Down syndrome helped to demonstrate the heterogenous character of mental disorders, whose causes can range from genetic with high penetrance, to largely ...
Maria Kiladi
wiley   +1 more source

The molecular basis of lactase persistence: Linking genetics and epigenetics

Annals of Human Genetics, EarlyView.
Abstract Lactase persistence (LP) — the genetic trait that determines the continued expression of the enzyme lactase into adulthood — has undergone recent, rapid positive selection since the advent of animal domestication and dairying in some human populations.
Céleste E. Cohen, Dallas M. Swallow, Catherine Walker   +2 more
wiley   +1 more source

Heritable polygenic editing: the next frontier in genomic medicine? [PDF]

Nature
Visscher PM, Gyngell C, Yengo L, Savulescu J.   +3 more
europepmc   +1 more source

Incorporating familial risk, lifestyle factors, and pharmacogenomic insights into personalized noncommunicable disease (NCD) reports for healthcare funder beneficiaries participating in the Open Genome Project

Annals of Human Genetics, EarlyView.
Abstract Introduction An ethics‐guided decision‐making framework was developed for applying pathology‐supported genetic testing, a multifaceted pharmacodiagnostic approach that translates population risk stratification into clinical utility. We introduce this service, supported by the Open Genome Project, which aligns with the beneficence principle in ...
Manie De Klerk, Nicole Van Der Merwe, Johny Erasmus, Lindiwe Whati, Kelebogile E. Moremi, Daniel W. Olivier, Maritha J. Kotze   +6 more
wiley   +1 more source

Genomic prediction in Persian walnut: Optimization levers according to genetic architecture of complex traits. [PDF]

Plant Genome
Bernard A, Bénéjam J, Roth M, Lheureux F, Dirlewanger E.   +4 more
europepmc   +1 more source

Genome‐wide association study on chronic postsurgical pain after abdominal surgeries in the UK Biobank

Anaesthesia, Volume 80, Issue 5, Page 499-510, May 2025.
Summary Introduction Chronic pain is one of the most common and severe complications after surgery, affecting quality of life and overall wellbeing of patients. Several risk factors have been identified but the mechanisms of chronic postsurgical pain development remain unclear.
Song Li, Masja K. Toneman, Judith P. M. Mangnus, Stefano Strocchi, Regina L. M. van Boekel, Kris C. P. Vissers, Richard P. G. ten Broek, Marieke J. H. Coenen   +7 more
wiley   +1 more source