Results 1 to 10 of about 8,261 (95)
Virology, 2015 New generation sequencing is greatly expanding the capacity to examine the composition of mutant spectra of viral quasispecies in infected cells and host organisms. Here we review recent progress in the understanding of quasispecies dynamics, notably the occurrence of intra-mutant spectrum interactions, and implications of fitness landscapes for virus ...
Andino, Raul, Domingo, Esteban
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Viral Quasispecies Evolution [PDF]
Microbiology and Molecular Biology Reviews, 2012 SUMMARYEvolution of RNA viruses occurs through disequilibria of collections of closely related mutant spectra or mutant clouds termed viral quasispecies. Here we review the origin of the quasispecies concept and some biological implications of quasispecies dynamics.
Domingo, Esteban +2 more
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PLoS Computational Biology, 2005 Quasispecies are clouds of genotypes that appear in a population at mutation-selection balance. This concept has recently attracted the attention of virologists, because many RNA viruses appear to generate high levels of genetic variation that may enhance the evolution of drug resistance and immune escape. The literature on these important evolutionary
Bull, J., Meyers, L., Lachmann, M.
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PLOS Genetics, 2019 Viral quasispecies refers to a population structure that consists of extremely large numbers of variant genomes, termed mutant spectra, mutant swarms or mutant clouds. Fueled by high mutation rates, mutants arise continually, and they change in relative frequency as viral replication proceeds.
Esteban Domingo, Celia Perales
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Memory in Viral Quasispecies [PDF]
Journal of Virology, 2000 ABSTRACT Biological adaptive systems share some common features: variation among their constituent elements and continuity of core information. Some of them, such as the immune system, are endowed with memory of past events. In this study we provide direct evidence that evolving viral quasispecies possess a molecular memory in the form of ...
Ruiz-Jarabo, Carmen M. +4 more
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Quasispecies and recombination
Theoretical Population Biology, 2006 Recombination is introduced into Eigen's theory of quasispecies evolution. Comparing numerical simulations of the rate equations in the non-recombining and recombining cases show that recombination has a strong effect on the error threshold and, for a wide range of mutation rates, gives rise to two stable fixed points in the dynamics. This bi-stability
Jacobi, Martin Nilsson, Nordahl, Mats
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PAQ: Partition Analysis of Quasispecies [PDF]
Bioinformatics, 2001 Abstract Motivation: The complexities of genetic data may not be accurately described by any single analytical tool. Phylogenetic analysis is often used to study the genetic relationship among different sequences. Evolutionary models and assumptions are invoked to reconstruct trees that describe the phylogenetic relationship among ...
P, Baccam +4 more
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Quasispecies theory for finite populations [PDF]
Physical Review E, 2010 13 pages, 8 ...
Park, J.M. +2 more
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From Quasispecies Theory to Viral Quasispecies: How Complexity has Permeated Virology [PDF]
Mathematical Modelling of Natural Phenomena, 2012 Peer ...
Domingo, Esteban, Perales, Celia
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Viral quasispecies complexity measures
Virology, 2016 Mutant spectrum dynamics (changes in the related mutants that compose viral populations) has a decisive impact on virus behavior. The several platforms of next generation sequencing (NGS) to study viral quasispecies offer a magnifying glass to study viral quasispecies complexity.
Josep, Gregori +5 more
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