Results 31 to 40 of about 8,280 (111)

The 30th anniversary of quasispecies [PDF]

EMBO reports, 2009
The meeting on ‘Quasispecies: past, present and future’ took place between 17 and 18 November 2008, in Barcelona, Spain, and was organized by J. Gomez, C. Lopez‐Galindez, M.A. Martinez & A. Mas. ![][1] A meeting was held in Barcelona, Spain, in November 2008 to celebrate the 30th anniversary of the publication of the article that described the ...
Domingo, Esteban, Wain-Hobson, Simon
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Deep Sequencing Reveals Dual Evolution of SARS‐CoV‐2: Insights Into Defective Genomes From Wuhan‐Hu‐1 Variants to Omicron Subvariants

Journal of Medical Virology, Volume 97, Issue 7, July 2025.
ABSTRACT SARS‐CoV‐2 has evolved from early variants dominating the first (B.1.5, B.1.1) and second (B.1.177) pandemic waves, which exhibited a higher frequency of minority mutants with deletions leading to Defective Viral Genomes (DVGs) in the spike region near the S1/S2 cleavage site than the Alpha, Beta, and Delta variants.
Carolina Campos, Marta Ibañez‐Lligoña, Sergi Colomer‑Castell, Josep Gregori, Damir Garcia‑Cehic, Cristina Andrés, Maria Piñana, Alejandra González‑Sánchez, Ariadna Rando‑Segura, Juliana Esperalba, Narcis Saubí, Maria Francesca Cortese, David Tabernero, Francisco Rodriguez‐Frias, Roser Ferrer, Juan Ignacio Esteban, Renate W. Kakze‐van der Honing, Andries A. Kampfraath, Júlia Vergara‐Alert, Joaquim Segalés, Wim H. M. van der Poel, Tomàs Pumarola, Andrés Antón, Josep Quer   +23 more
wiley   +1 more source

Hepatitis B Virus Variants and Cytokine Patterns in Acute Liver Failure and Transplant‐Free Survival

Liver International, Volume 45, Issue 7, July 2025.
ABSTRACT Background & Aims Only 25% of hepatitis B‐related acute liver failure (HBV‐ALF) patients survive without liver transplantation (transplant‐free survival, TFS). There is limited study of immunological and virological profiles in these patients.
Nishi H. Patel, Annie Y. Chen, Carla Osiowy, Valerie Durkalski Mauldin, William M. Lee, Carla S. Coffin, Constantine J. Karvellas, the US Acute Liver Failure Study Group, W. M. Lee, Anne M. Larson, Iris Liou, Oren Fix, Michael Schilsky, Timothy McCashland, J. Eileen Hay, Natalie Murray, A. Obaid S. Shaikh, Andres Blei, Daniel Ganger, Atif Zaman, Steven H. B. Han, Robert Fontana, Brendan McGuire, Raymond T. Chung, Alastair Smith, Robert Brown, Jeffrey Crippin, Edwin Harrison, Adrian Reuben, Santiago Munoz, Rajender Reddy, R. Todd Stravitz, Lorenzo Rossaro, Raj Satyanarayana, Tarek Hassanein, Constantine J. Karvellas, Jodi Olson, Ram Subramanian, James Hanje, Ezmina Lalani, Carla Pezzia, Nahid Attar, Linda S. Hynan, Valerie Durkalski, Wenle Zhao, Jaime Speiser, Catherine Dillon, Holly Battenhouse, Michelle Gottfried   +48 more
wiley   +1 more source

Genetic Evolution Between HIV‐1 Groups M and O: HIV‐1/MO Recombinant Forms

Journal of Medical Virology, Volume 97, Issue 5, May 2025.
ABSTRACT HIV exhibits significant genetic diversity, with genetic recombination being a major evolutionary process. The co‐circulation of HIV‐1/M and HIV‐1/O variants has led to the description of 20 HIV‐1/M+O dual infections since 1998. Despite the genetic divergence between these variants, HIV‐1/M+O dual infections have resulted in the emergence of ...
Alice Moisan, Fabienne Tombette, Jean‐Christophe Plantier   +2 more
wiley   +1 more source

Quasispecies of dengue virus

Tropical Medicine and Health, 2011
Pathogenic viruses have RNA genomes that cause acute and chronic infections. These viruses replicate with high mutation rates and exhibit significant genetic diversity, so-called viral quasispecies. Viral quasispecies play an important role in chronic infectious diseases, but little is known about their involvement in acute infectious diseases such as ...
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Quasispecies dynamics with network constraints

Journal of Theoretical Biology, 2012
A quasispecies is a set of interrelated genotypes that have reached a situation of equilibrium while evolving according to the usual Darwinian principles of selection and mutation. Quasispecies studies invariably assume that it is possible for any genotype to mutate into any other, but recent finds indicate that this assumption is not necessarily true.
Barbosa, Valmir C., Donangelo, Raul, Souza, Sergio R.   +2 more
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RNA Virus Populations as Quasispecies [PDF]

, 1992
RNA virus mutation frequencies generally approach maximum tolerable levels, and create complex indeterminate quasispecies populations in infected hosts. This usually favors extreme rates of evolution, although periods of relative stasis or equilibrium, punctuated by rapid change may also occur (as for other life forms).
J J, Holland, J C, De La Torre, D A, Steinhauer   +2 more
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Population Bottlenecks in Quasispecies Dynamics

, 2006
The characteristics of natural populations result from different stochastic and deterministic processes that include reproduction with error, selection, and genetic drift. In particular, population fluctuations constitute a stochastic process that may play a very relevant role in shaping the structure of populations.
Escarmís, Cristina, Lázaro, Ester, Manrubia Cuevas, Susanna   +2 more
openaire   +3 more sources

Breaking the Mould: How the First Structure of a Deer Prion Suggests the Framework for Interspecies Strain Diversity and Transmission Barriers

Journal of Neurochemistry, Volume 169, Issue 3, March 2025.
The normal prion protein (PrPC) fold is shared among mammals; however, it can undergo misfolding in various ways, giving rise to distinct infectious prion (PrPSc) strains. This review describes independent misfolding subdomains within PrP, recognised through new structural alignments and comparisons with the novel deer chronic wasting disease (CWD ...
Szymon W. Manka
wiley   +1 more source

Natural Resistance to HIV Infection: Role of Immune Activation

Immunity, Inflammation and Disease, Volume 13, Issue 2, February 2025.
High and low immune activation have been proposed as a possible explanation in HIV‐1 resistance. This review focuses on the most relevant evidence supporting each perspective. ABSTRACT Introduction Although repeated exposure to HIV‐1 can result in infection, some individuals remain seronegative without clinical or serologic evidence of infection; these
María M. Naranjo‐Covo, Daniel S. Rincón‐Tabares, Lizdany Flórez‐Álvarez, Juan C. Hernandez, Wildeman Zapata‐Builes   +4 more
wiley   +1 more source