Results 131 to 140 of about 13,731 (218)

Synthesis of 3-(arylamino) quinazoline-2,4(1H,3H)-dione derivatives via TBHP/I2: Molecular docking, MD simulation, DFT, and pharmacological evaluation as MTH1 inhibitors. [PDF]

PLoS One
Karim MG, Mehrdad M, Gheidari D, Gheidari NZ.   +3 more
europepmc   +1 more source

A trifluoromethyl quinazoline inhibits hepatocellular carcinoma proliferation through HDAC1 binding and multi-target mechanisms. [PDF]

iScience
Wang S, Cui X, Yu G, Wan X, Wei S, Yu J, Cheng S, Zhang D, Ayaka T, Wang X, Han W, Xu B, Luo H, Yu L.   +13 more
europepmc   +1 more source

Discovery of novel quinazoline-sulfonamide derivatives with promising antidiabetic activity. [PDF]

Front Chem
Zayed MF, Muhammad Y, Alqurain AA, Banafa MAA, Omar AM.   +4 more
europepmc   +1 more source

Mechanistic Exploration of the anticancer activity of Justicia adhatoda Plant Leaf Ethanolic Extract against Colon Cancer Cells: An in silico and in vitro Approach. [PDF]

Asian Pac J Cancer Prev
Ponnusamy B, Rajagopal P, Palanisamy CP, Veeraraghavan VP, Jayaraman S.   +4 more
europepmc   +1 more source

Discovery of EGT710, an Oral Nonpeptidomimetic Reversible Covalent SARS-CoV-2 Main Protease Inhibitor. [PDF]

J Med Chem
Papillon JPN, Yuan J, Hesse MJ, Zhang L, Robinson RI, Ware NF, Hornak V, Karki RG, Kirrane T, Garland K, Joseph S, Moquin SA, Lakshminarayana SB, Tandeske L, Dovala D, Knapp M, Ornelas E, Fuller D, Ho PI, Xie X, Vulic K, Skolnik SM, Gao J, Zambrowski M, Spiess M, Duca JS, Busby SA, Schirle M, Robinson M, Shi PY, Moser HE, Sarko C, Bradner JE, Diagana TT, Tallarico JA.   +34 more
europepmc   +1 more source

Recent advances in HER2-targeted inhibitors for cancer therapy. [PDF]

Pharm Sci Adv
Zhu W, Lu X.
europepmc   +1 more source

Efficient Synthesis and Characterization of Lidocaine Analogue N-Ethyl-N-((8-methylquinazolin-2-yl)methyl)ethanamine

SynOpen
Sang Woo Woo, Jae Ho Shim, Jihye Han, Jin Ju Lim, Hyeon Soo Kim   +4 more
doaj   +1 more source

Scaffold Hopping-Guided Design of Novel PIM-1 Inhibitors with Anticancer Activities. [PDF]

Molecules
Xin Y, Wu Q, Gao Y, Xiao C, You Q, Jiang Z, Lu M.   +6 more
europepmc   +1 more source

Anti-Inflammatory Evaluation of Pyrazino[2,1-<i>b</i>]quinazoline-3,6-dione Derivatives Inspired by Fiscalin B. [PDF]

Pharmaceuticals (Basel)
Martins MS, Pinto MMM, Almeida IF, Cruz MT, Sousa E.   +4 more
europepmc   +1 more source

Chemical Scaffolds Driving Modern Anticancer Drug Discovery and Radiotheranostics: Structural Determinants, Translational Opportunities and Future Perspectives. [PDF]

Pharmaceuticals (Basel)
Rusek M.
europepmc   +1 more source