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Quinazoline derivatives with antitubercular activity
Il Farmaco, 20004-Quinazolinol was prepared by the reaction of anthranilic acid and formamide. The hydroxy group was converted into the thiol function by treatment with phosphorus(V)sulfide, and the subsequent alkylation of the thiol group was carried out with alkylhalides under the conditions of phase-transfer catalysis.
J, Kunes +5 more
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Dermatitis from quinazoline oxide
Contact Dermatitis, 1986Dermatitis from 2‐chloromethyl‐4‐phenyl‐6‐chloroquinazoline‐3‐oxide, an intermediate product in the preparation of chlorodiazepoxide, is described in 29 workers at a pharmaceutical plant. All were patch test positive to quinazoline oxide (1%) and six to 0.05%. In most patients, the face was earlier and more severely involved than the hands.
P, Rebandel, E, Rudzki
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ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
N. N. Tonkikh +2 more
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AbstractFor Abstract see ChemInform Abstract in Full Text.
N. N. Tonkikh +2 more
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Biology of quinoline and quinazoline alkaloids
2022Quinoline and quinazoline alkaloids, two important classes of N-based heterocyclic compounds, have attracted scientific and popular interest worldwide since the 19th century. More than 600 compounds have been isolated from nature to date. To build on our two prior reviews, we reexamined the promising molecules described in previous reports and provided
Xiao-Fei, Shang +5 more
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Quinazoline analogues of folic acid
Journal of the Chemical Society C: Organic, 1970Analogues of folic acid having the pteridine ring replaced by quinazoline have been prepared by reductive condensation of appropriately substituted quinazoline-6-carbaldehydes and -carbonitriles with diesters of N-(p-aminobenzoyl) amino-acids, followed by hydrolysis.
J, Davoll, A M, Johnson
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Quinazolines. Part VIII. Electronic effects in 2-substituted quinazolines
Journal of the Chemical Society C: Organic, 1966In a study of the cations of twenty 2-substituted quinazolines, it was found that covalent hydration of the 3,4-double bond decreased according to the electronic effect of the 2-substituent; viz, +l > +M > –l. This is explained by the effect of the substituent on the polarity of the C-4, N-3 double bond. The effect of the acyl group on the rate of ring
W. L. F. Armarego, J. I. C. Smith
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Quinazolines as Inhibitors of Xanthe Oxidase
Journal of Pharmaceutical Sciences, 1974A series of 23 quinazolines and 5,6,7,8-tetrahydroquinazolines was evaluated for inhibition of bovine milk xanthine oxidase. The synthesis of four of these compounds has not been reported previously. Several 2-amino-4-hydroxyquinazolines, as well as 2-amino-4-mercaptoquinazoline, were effective inhibitors of this enzyme.
D G, Priest +3 more
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Nature, 1964
THE polarographic behaviour of quinazoline displays special features which are not shown by the related compounds quinoxaline, phthalazine and 1,5-naphthyridine.
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THE polarographic behaviour of quinazoline displays special features which are not shown by the related compounds quinoxaline, phthalazine and 1,5-naphthyridine.
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Quinazolines. Part X. The fragmentation of quinazolines under electron impact
Journal of the Chemical Society B: Physical Organic, 1967Quinazoline, under electron impact, fragments by the consecutive loss of two molecules of HCN to give a benzyne radical ion. Fragmentation of substituted quinazolines also occurs by this pathway as well as by others normally associated with the breakdown of the substituent.
T. J. Batterham +2 more
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Synthesis of Unsymmetrical Dialkoxy Quinazolines.
ChemInform, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
Matthieu Desroses +3 more
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