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Tuning potency for precision: the role of the G4-ligand in G4-ligand conjugated oligonucleotides targeting individual G-quadruplex DNA structures. [PDF]
RSC Chem BiolAbrahamsson A +7 more
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Quinazolines. Part XV. Hexahydro- and octahydro-quinazolines
Journal of the Chemical Society C: Organic, 19713,4,5,6,7,8-Hexahydroquinazoline, obtained by catalytic reduction of 5,6,7,8-tetrahydroquinazoline, was slowly oxidised by air to the starting material in chloroform solution, but in aqueous alkali it was degraded to 2-formamidomethylcyclohexanone. trans-4a,5,6,7,8,8a-Hexahydroquinazolin-4(1 - or 3-H)-one was shown to be a tautomeric mixture of the (1H)
W. L. F. Armarego, Toshihiko Kobayashi
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Synthesis of Quinazolinones and Quinazolines
ChemInform, 2005AbstractFor Abstract see ChemInform Abstract in Full Text.
David J. Connolly +3 more
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Pharmacology, 2008
Piquizil, a 4-aminoquinazoline causing relaxation of respiratory smooth muscle in animals, appeared to be a bronchodilator in man. A metabolite of piquizil was isolated from human urine and identified. This metabolite, named hoquizil, had a longer plasma half-time than piquizil, was generally of comparable pharmacological activity, but was better ...
M. Schach von Wittenau, T.F. Brewer
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Piquizil, a 4-aminoquinazoline causing relaxation of respiratory smooth muscle in animals, appeared to be a bronchodilator in man. A metabolite of piquizil was isolated from human urine and identified. This metabolite, named hoquizil, had a longer plasma half-time than piquizil, was generally of comparable pharmacological activity, but was better ...
M. Schach von Wittenau, T.F. Brewer
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Tetrahedron, 1986
Abstract Grignard reagents reacted with 2-aminobenzonitrile to give the intermediate 10 , which readily could be cyclized to quinazolines by reaction with carbonyl compounds (e.g. acid chlorides, anhydrides, formates and oxalates). The intermediate 10 and aldehydes, e.g.
Jan Bergman +3 more
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Abstract Grignard reagents reacted with 2-aminobenzonitrile to give the intermediate 10 , which readily could be cyclized to quinazolines by reaction with carbonyl compounds (e.g. acid chlorides, anhydrides, formates and oxalates). The intermediate 10 and aldehydes, e.g.
Jan Bergman +3 more
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1984
Quinazoline (1) is a building block for approximately eighty naturally occurring alkaloids isolated from a number of families of the plant kingdom, from microorganisms and from animals. The first known quinazoline alkaloid was vasicine (peganine), isolated in 1888 from Adhatoda vasica, and later from other species.
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Quinazoline (1) is a building block for approximately eighty naturally occurring alkaloids isolated from a number of families of the plant kingdom, from microorganisms and from animals. The first known quinazoline alkaloid was vasicine (peganine), isolated in 1888 from Adhatoda vasica, and later from other species.
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