Quinazolines [a]-Annelated by Five-Membered Heterocycles: Synthesis and Biological Activity [PDF]
MoleculesThis review covers article and patent data obtained mostly within the period 2013–2024 on the synthesis and biological activity of quinazolines [a]-annelated by five-membered heterocycles.
Galina N. Lipunova +2 more
doaj +2 more sources
Research towards selective inhibition of the CLK3 kinase [PDF]
Beilstein Journal of Organic ChemistryThe cdc2-like kinases (CLKs), are a family of kinases that attracted recently the interest of scientists due to their significant biological roles, in particular in the regulation of the mRNA splicing process. Among the four isoforms of CLKs, CLK3 is the
Vinay Kumar Singh +9 more
doaj +2 more sources
Recent Advances in Metal-Catalyzed Approaches for the Synthesis of Quinazoline Derivatives [PDF]
MoleculesQuinazolines are an important class of heterocyclic compounds that have proven their significance, especially in the field of organic synthesis and medicinal chemistry because of their wide range of biological and pharmacological properties.
Nitesh K. Nandwana +4 more
doaj +2 more sources
Synthesis of 4-tosyl quinazoline derivatives with the assistance of ultrasound irradiation as a guide to the reaction pathway [PDF]
Scientific ReportsIn this study, we tried to show the role of ultrasonic waves in the reaction pathway of quinazolines with an amide functional group. At first, 4-tosyl quinazolines were prepared using a simple, rapid, and one-pot reaction of Cu-catalyzed cross-coupling ...
Manijeh Nematpour
doaj +2 more sources
Synthesis and cytotoxicity studies of novel N-arylbenzo[h]quinazolin-2-amines [PDF]
Beilstein Journal of Organic ChemistryIn this paper, we report a short and efficient synthesis of novel N-arylbenzo[h]quinazoline-2-amines. We have prepared a focused library of nineteen representative examples which have been submitted to cytotoxicity assays against a representative panel ...
Battini Veeraiah +8 more
doaj +2 more sources
Regioselective quinazoline C2 modifications through the azide–tetrazole tautomeric equilibrium [PDF]
Beilstein Journal of Organic Chemistry2-Chloro-4-sulfonylquinazolines undergo functional group swap when treated with an azide nucleophile: 1) the azide replaces the sulfonyl group at the C4 position; 2) the intrinsic azide–tetrazole tautomeric equilibrium directs the nucleofugal sulfinate ...
Dāgs Dāvis Līpiņš +5 more
doaj +2 more sources
Chemical Insights Into the Synthetic Chemistry of Quinazolines: Recent Advances
Frontiers in Chemistry, 2021 In medicinal chemistry, one of the most significant heterocyclic compounds are quinazolines, possessing broad range of biological properties such as anti-bacterial, anti-fungal, anti-HIV, anti-cancer, anti-inflammatory, and analgesic potencies.
Muhammad Faisal, Aamer Saeed
doaj +1 more source
Transition-metal-catalyzed synthesis of quinazolines: A review
Frontiers in Chemistry, 2023 Quinazolines are a class of nitrogen-containing heterocyclic compounds with broad-spectrum of pharmacological activities. Transition-metal-catalyzed reactions have emerged as reliable and indispensable tools for the synthesis of pharmaceuticals.
Rekha Tamatam +4 more
doaj +1 more source
Recent Advances in the Transition-Metal-Free Synthesis of Quinazolines
Molecules, 2023 Quinazolines are a privileged class of nitrogen-containing heterocycles, widely present in a variety of natural products and synthetic chemicals with a broad spectrum of biological and medicinal activities.
Rekha Tamatam, Dongyun Shin
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2023 For the first time, we elaborated a method for the synthesis of pyrimidines containing an allomaltol unit. The suggested approach is based on the reaction of 2-(1-(dimethylamino)-3-oxo-3-arylprop-1-en-2-yl)-3-hydroxy-6-methyl-4H-pyran-4-ones with ...
Constantine V. Milyutin +4 more
doaj +1 more source