Results 11 to 20 of about 6,888 (163)

Synthesis and Biological Evaluation of 2-Substituted Quinazolin-4(3H)-Ones with Antiproliferative Activities

Molecules, 2023
Sixteen new 2-substituted quinazolines were synthesized using a straightforward methodology starting from 2-methoxybezoic acid or 3-methoxy-2-naphthoic acid.
Maria Karelou, Dionysis Kampasis, Amalia D. Kalampaliki, Leentje Persoons, Andreas Krämer, Dominique Schols, Stefan Knapp, Steven De Jonghe, Ioannis K. Kostakis   +8 more
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Direct CH/CH functionalization of 1,3-dihydroxy-9H-xanthen-9-one and 1,3-dimethoxy-9H-xanthen-9-one with 1,2,4-triazines and quinazoline

Chimica Techno Acta, 2020
An electron-deficient series of 1,2,4-triazines and quinazoline have been used for cross-dehydrogenative coupling with 1,3-dihydroxy and 1,3-dimethoxyxanthones to give stable nucleophilic addition products.
A. D. Sharapov, R. F. Fatykhov, I. A. Khalymbadzha, O. N. Chupakhin   +3 more
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Substituted pyrrolo[1,2-a][1,2,4]triazolo-(triazino-)[c]quinazolines - a promising class of lipoxygenase inhibitors

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2020
The modern strategy of potential biologically active molecules search (“drug-design”) is based on several innovation approaches. The method of high thrоughрut biological screening and method of molecular modeling deserves the most attention among such ...
V. V. Stavytskyi, I. S. Nosulenko, O. O. Portna, V. M. Shvets, O. Yu. Voskoboynik, S. І. Kоvalenko   +5 more
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Carboxyl-containing quinazolines and related heterocycles as carriers of anti-inflammatory activity

Zaporožskij Medicinskij Žurnal, 2022
Active pharmaceutical ingredients whose structure combines aromatic or heterocyclic fragments with pharmacophore carboxylic group are widespread on pharmaceutical market.
N. I. Krasovska, V V. Stavytskyi, I. S. Nosulenko, O. Yu. Voskoboinik, S. I. Kovalenko   +4 more
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Synthesis and Photophysical Property Studies of the 2,6,8-Triaryl-4-(phenylethynyl)quinazolines

Molecules, 2014
The 2-aryl-6,8-dibromo-4-chloroquinazolines derived from the 2-aryl-6,8-dibromoquinazolin-4(3H)-ones were subjected to the Sonogashira cross-coupling with terminal acetylenes at room temperature to afford novel 2-aryl-6,8-dibromo-4-(alkynyl)quinazoline ...
Malose Jack Mphahlele, Hugues Kadem Paumo, Ahmed M. El-Nahas, Morad M. El-Hendawy   +3 more
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Metal-Free Synthesis of 2-Substituted Quinazolines via Green Oxidation of o-Aminobenzylamines: Practical Construction of N-Containing Heterocycles Based on a Salicylic Acid-Catalyzed Oxidation System

Frontiers in Chemistry, 2022
Conventional quinazoline synthesis methods involve a highly multistep reaction, and often require excess amounts of substrate to control the product selectivity, leading to significant resource wastage.
Yuki Yamamoto, Chihiro Yamakawa, Riku Nishimura, Chun-Ping Dong, Shintaro Kodama, Akihiro Nomoto, Michio Ueshima, Akiya Ogawa   +7 more
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Quinazoline-containing Hydrazydes of Dicarboxylic Acids and Products of Their Structural Modification – A Novel Class of Anti-inflammatory Agents

Acta Chimica Slovenica, 2021
The synthesis of hydrazides formed by quinazolin-4(3H)-ylidenehydrazine and dicarboxylic acids, as well as their further modification are described in the present manuscript.
Nataliia Krasovska, Viktor Stavytskyi, Inna Nosulenko, Oleksandr Karpenko, Oleksii Voskoboinik, Serhii Ivanovych Kovalenko   +5 more
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Synthesis of indolo[1,2-c]quinazolines from 2-alkynylaniline derivatives through Pd-catalyzed indole formation/cyclization with N,N-dimethylformamide dimethyl acetal

Beilstein Journal of Organic Chemistry, 2018
An efficient strategy for the synthesis of 6-unsubstituted indolo[1,2-c]quinazolines is described. The Pd-catalyzed reaction of o-(o-aminophenylethynyl) trifluoroacetanilides with Ar–B(OH)2 afforded 2-(o-aminophenyl)-3-arylindoles, that were converted to
Antonio Arcadi, Sandro Cacchi, Giancarlo Fabrizi, Francesca Ghirga, Antonella Goggiamani, Antonia Iazzetti, Fabio Marinelli   +6 more
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Synthesis of SF5-containing benzisoxazoles, quinolines, and quinazolines by the Davis reaction of nitro-(pentafluorosulfanyl)benzenes

Beilstein Journal of Organic Chemistry, 2013
Meta- or para-nitro-(pentafluorosulfonyl)benzenes underwent the Davis reaction with arylacetonitriles to provide the SF5-containing benzisoxazoles. Good yields were obtained with arylacetonitriles containing the electron-neutral or electron-donor group ...
Petr Beier, Tereza Pastýříková
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Investigation of growth stimulating activity of 2-heteryl-[1,2,4]triazolo [1,5-c]quinazolines and products of its nucleophilic degradation

Zaporožskij Medicinskij Žurnal, 2013
Nucleophilic degradation of 2-heteryl-[1,2,4]triazolo[1,5-c]quinazolines was investigated and the structure of {2-(3-heteryl)-1H-1,2,4-triazol-5-yl]phenyl}ami­nes was unequivocally proved by spectral methods.
A. K. Bilyi, S. I. Kovalenko, O. V. Prihodko   +2 more
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