Results 21 to 30 of about 6,888 (163)

Structure Activity Relationship and Molecular Docking of Some Quinazolines Bearing Sulfamerazine Moiety as New 3CLpro, cPLA2, sPLA2 Inhibitors

Molecules, 2023
The current work was conducted to synthesize several novel anti-inflammatory quinazolines having sulfamerazine moieties as new 3CLpro, cPLA2, and sPLA2 inhibitors.
Mohammed Abdalla Hussein, Rita M. Borik, Mohamed S. Nafie, Heba M. Abo-Salem, Sylvia A. Boshra, Zahraa N. Mohamed   +5 more
doaj   +1 more source

One-Pot Tandem Synthesis of 2-Arylquinazolines by a Multicomponent Cyclization Reaction

Molecules, 2013
A series of 2-arylquinazolines have been synthesized in moderate to excellent yields by one-pot tandem reaction of (2-aminophenyl)methanols, aldehydes and ceric ammonium nitrate (CAN).
Xiaodong Xia, Leping Ye, Lijun Zhu, Lin Yu   +3 more
doaj   +1 more source

3D,2D-QSAR study and docking of novel quinazolines as potential target drugs for osteosarcoma

Frontiers in Pharmacology, 2023
Background: Quinazolines are an important class of benzopyrimidine heterocyclic compounds with a promising antitumor activity that can be used for the design and development of osteosarcoma target compounds.Objective: To predict the compound activity of ...
Zheng Lian, Chenglin Sang, Nianhu Li, Honglin Zhai, Wenzhe Bai   +4 more
doaj   +1 more source

Medicinal Chemistry of Quinazolines as Anticancer Agents Targeting Tyrosine Kinases

Scientia Pharmaceutica, 2023
Cancer is a large group of diseases that can affect any organ or body tissue due to the abnormal cellular growth with the unknown reasons. Many of the existing chemotherapeutic agents are highly toxic with a low level of selectivity.
Mohamed F. Zayed
doaj   +1 more source

Synthesis and Photophysical Properties of Polycarbo-Substituted Quinazolines Derived from the 2-Aryl-4-chloro-6-iodoquinazolines

Molecules, 2015
The reactivity of the 2-aryl-4-chloro-6-iodoquinazolines towards palladium catalyzed sequential (Sonogashira/Suzuki-Miyaura) and one-pot two-step cross-coupling (bis-Sonogashira, and successive Sonogashira/Stille) reactions to afford novel unsymmetrical
Malose Jack Mphahlele, Hugues Kamdem Paumo, Lydia Rhyman, Ponnadurai Ramasami   +3 more
doaj   +1 more source

Conjugate Addition of Nucleophiles to the Vinyl Function of 2-Chloro-4-vinylpyrimidine Derivatives

Molecules, 2010
Conjugate addition reaction of various nucleophiles across the vinyl group of 2-chloro-4-vinylpyrimidine, 2-chloro-4-(1-phenylvinyl)pyrimidine and 2-chloro-4-vinylquinazoline provides the corresponding 2-chloro-4-(2-substituted ethyl)pyrimidines and 2 ...
Lucjan Strekowski, Jarosław Sączewski, Jeffrey Klenc, Ava Blake, Elizabeth Raux   +4 more
doaj   +1 more source

Benzo[g]quinazolines as antifungal against candidiasis: Screening, molecular docking, and QSAR investigations

Saudi Pharmaceutical Journal, 2023
Candida albicans, an opportunistic pathogen, is the most common type of fungus and represents a substantial source of human invasive disease (nosocomial infection).
Hatem A. Abuelizz, Ahmed H. Bakheit, Mohamed H. Al-Agamy, Harunor Rashid, Gamal A.E. Mostafa, Rashad Al-Salahi   +5 more
doaj   +1 more source

Advances in Metal-Catalyzed Cross-Coupling Reactions of Halogenated Quinazolinones and Their Quinazoline Derivatives

Molecules, 2014
Halogenated quinazolinones and quinazolines are versatile synthetic intermediates for the metal-catalyzed carbon–carbon bond formation reactions such as the Kumada, Stille, Negishi, Sonogashira, Suzuki-Miyaura and Heck cross-coupling reactions or ...
Malose Jack Mphahlele, Marole Maria Maluleka   +1 more
doaj   +1 more source

Design, synthesis, and carbonic anhydrase inhibition activities of Schiff bases incorporating benzenesulfonamide scaffold: Molecular docking application

Saudi Pharmaceutical Journal, 2023
In this study, The inhibitory actions of human carbonic anhydrase (CA, EC 4.2.1.1) (hCA) isoforms I, II, IX, and XII are being examined using recently synthesized substituted hydroxyl Schiff derivatives based on the quinazoline scaffold 4–22 ...
Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Silvia Bua, Alessio Nocentini, Ahmed H. Bakheit, Hamad M. Alkahtani, Mohamed M. Hefnawy, Claudiu T. Supuran   +7 more
doaj   +1 more source

Novel Polycarbo-Substituted Imidazo[1,2-c]quinazolines: Synthesis and Cytotoxicity Study

Molecules, 2015
Amination of the 2-aryl-6-bromo-4-chloro-8-iodoquinazolines with 2-aminoethanol followed by acid-promoted cyclodehydration of the incipient 2-((6,8-dihalo-2-phenylquinazolin-4-yl)amino)ethanols afforded the corresponding novel 5-aryl-9-bromo-7-iodo-2,3 ...
Tebogo Ankie Khoza, Tshepiso Jan Makhafola, Malose Jack Mphahlele   +2 more
doaj   +1 more source