Results 61 to 70 of about 6,888 (163)

Design, Synthesis, and Biological Evaluation of 4-aminoquinazoline Appended-Benzofuran Hybrids as Epidermal Growth Factor Receptor Inhibitors

Proceedings, 2019
Nitrogen-containing heterocycles such as quinazolines and benzofurans have received a great amount of interest in targeted therapies as antitumor drugs [1]. [...]
Marole Maria Maluleka, Malose Jack Mphahlele   +1 more
doaj   +1 more source

Exploration and Characterization of the Antimalarial Activity of Pyrimidine‐2,4‐Diamines for which Resistance is Mediated by the ABCI3 Transporter

ChemMedChem, Volume 21, Issue 1, January 2026.
Investigation of the structure‐activity relationship on W482 (1) with a pyrimidine‐2,4‐diamine scaffold culminated in analog 51 with enhanced anti‐plasmodial activity. Forward genetics and phenotypic examination revealed the ABCI3 transporter protein as a putative resistance mechanism.
Mahta Mansouri, Madeline G. Dans, Zijun Low, Katie Loi, Kate E. Jarman, Jocelyn S. Penington, Deyun Qiu, Adele M. Lehane, Benigno Crespo, Franciso‐Javier Gamo, Delphine Baud, Stephen Brand, Paul F. Jackson, Alan F. Cowman, Brad E. Sleebs   +14 more
wiley   +1 more source

Design, Synthesis, and Cytotoxicity Evaluation of Novel Indolin-2-One Based Molecules on Hepatocellular Carcinoma HepG2 Cells as Protein Kinase Inhibitors

Molecules
A series of indolinone-based derivatives were designed and synthesized using the hybrid pharmacophoric design approach as cytotoxic kinase inhibitors.
Manal M. Kandeel, Mohamed Kamal AbdElhameid, Mohamed Adel, Muhammad Y. Al-Shorbagy, Ahmed T. Negmeldin   +4 more
doaj   +1 more source

Natural Products Targeting the EGFR/HER2 Axis in Tumorigenesis: Interpretation of Molecular Mechanisms and Recent Insights Into Synergistic Strategies for Cancer Therapy

Food Frontiers, Volume 7, Issue 1, January 2026.
Schematic overview illustrating the anticancer mechanisms of selected natural products (resveratrol, quercetin, berberine) targeting EGFR and HER2 signaling pathways in tumor cells. These compounds inhibit receptor activation and downstream oncogenic cascades, including PI3K/Akt/mTOR, MAPK/ERK, and STAT3 pathways.
Iman Ramli, Anna Maria Posadino, Roberta Giordo, Antonio Barberis, Ylenia Spissu, Redouane Lemoui, William N. Setzer, Javad Sharifi‐Rad, Gianfranco Pintus   +8 more
wiley   +1 more source

Organoids in Cancer Research and Regenerative Medicine: Current Status, Challenges, and Future Prospects

MedComm, Volume 7, Issue 1, January 2026.
The management of cancer and tissue regeneration remains a substantial challenge to global health. Organoids, which are stem cell‐derived three‐dimensional multicellular structures, are revolutionizing biomedical research. Therefore, this review highlights their applications in cancer research and regenerative medicine, while discussing current ...
Ruiyang Li, Yuezhou Wu, Zhu'anzhen Zheng, Fengjin Zhou, Ke Xu, Jiacan Su   +5 more
wiley   +1 more source

Recent advances in 4-aminoquinazoline based scaffold derivatives targeting EGFR kinases as anticancer agents

Future Journal of Pharmaceutical Sciences, 2016
Quinazoline derivatives are fused heterocyclic ring systems which have been explored for their inhibitory activity towards various protein kinase enzymes and their role as anticancer agents.
Rania S.M. Ismail, Nasser S.M. Ismail, Sahar Abuserii, Dalal A. Abou El Ella   +3 more
doaj   +1 more source

Analgetic Activity of a Quinazoline

Experimental Biology and Medicine, 1967
SummaryFour test systems were used to demonstrate the analgetic activity of Su-13026, a quinazoline compound, in mice, rats and rabbits. Signs of central nervous system stimulation were noted. Respiration was not depressed in any of the species studied. Nalorphine did not antagonize, nor did amphetamine potentiate, the activity of this compound in mice.
H I, Chernov, H M, Blatter, P S, Bernard, D E, Wilson, A J, Plummer   +4 more
openaire   +2 more sources

Quinazolines. Part IV.

, 1936
Quinazolines. Part IV.
SANT SINGH BEDI, KARTAR SINGH NARANG
openaire   +1 more source

Quinazoline compounds for antitumor treatment

Experimental Oncology, 2023
Summary. Quinazolines are among the most useful heterocyclic compounds due to their diverse chemical reactivity and a wide range of biological activity. Despite a large number of publications devoted to quinazolines and their derivatives, information is presented predominantly regarding the features of the synthesis of these compounds and their ...
openaire   +2 more sources

Facile access to potent antiviral quinazoline heterocycles with fluorescence properties via merging metal-free domino reactions

Nature Communications, 2017
Heterocycles are ubiquitous in bioactive compounds and routes to different substitution patterns are important to access the full substrate space.
Felix E. Held, Anton A. Guryev, Tony Fröhlich, Frank Hampel, Axel Kahnt, Corina Hutterer, Mirjam Steingruber, Hanife Bahsi, Clemens von Bojničić-Kninski, Daniela S. Mattes, Tobias C. Foertsch, Alexander Nesterov-Mueller, Manfred Marschall, Svetlana B. Tsogoeva   +13 more
doaj   +1 more source