Results 111 to 120 of about 38,082 (231)

One-Pot Synthesis and Anticancer Activity Evaluation of Indolo[1,2-<i>a</i>]quinoline-7-carbonitrile Derivatives. [PDF]

Molecules
Yimnoi K, Boosaman N, Chuanopparat N, Jearawuttanakul K, Seemakhan S, Khumpanied T, Wannalo W, Borwornpinyo S, Ngernmeesri P.   +8 more
europepmc   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, Volume 46, Issue 6, Page 1477-1498, November 2026.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Recent Advances in Microwave and Ultrasound Assisted Synthesis of Quinoline Derivatives as Anticancer Agents. [PDF]

Chem Biodivers
Pal R, Matada GSP, Teli G, B V M, Pandey VK, Pratap S.   +5 more
europepmc   +1 more source

Reactions of Isomeric Triplet and Singlet Aryloxenium Cations in the Gas Phase

Journal of Physical Organic Chemistry, Volume 39, Issue 11, November 2026.
This study presents a detailed experimental and computational examination of the gas‐phase reactivity and the reactive sites of the triplet 2‐amino‐4‐pyridyloxenium cation. It also provides a direct comparison of this reactivity to that of the isomeric singlet 3‐amino‐4‐pyridyloxenium cation and 3‐amino‐2‐pyridyloxenium cation that have not been ...
Tuong V. Nguyen, Markus Rohdenburg, Jonas Warneke, John J. Nash, Hilkka I. Kenttämaa   +4 more
wiley   +1 more source

Quinoline-Based Scaffolds in Anticancer Drug Discovery: Molecular Targets, Synthetic Strategies, and Biological Advances. [PDF]

ChemMedChem
Raza A, Wadhwa P, Sharma S.
europepmc   +1 more source

Nucleophilic Aromatic Substitution in the Gas Phase

Journal of Physical Organic Chemistry, Volume 39, Issue 11, November 2026.
In this review, we highlight experimental studies of gas‐phase SNAr. Studying reactions in the gas phase provides invaluable information on intrinsic reactivity by eliminating the complications of solvent effects. Because SNAr is a fundamental reaction in chemical research and organic synthesis, understanding its underlying reactivity and mechanisms is
Daniel N. Hirsch, Damon J. Hinz, Jeehiun K. Lee   +2 more
wiley   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, Volume 183, Issue 22, Page 6574-6606, November 2026.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Adaptive Hydrogenation of Alkynes Using CO as a Molecular Trigger to Selectively Produce Alkanes or Z‐Alkenes

Angewandte Chemie, Volume 138, Issue 44, 26 October 2026.
One catalyst for two products: CO acts as a molecular trigger for adaptive alkyne hydrogenation using supported Pd nanoparticles. The catalyst reversibly switches between the formation of alkanes under H2 and Z‐alkenes under H2/CO for 37 structurally diverse alkynes.
Manisha Durai, Lachlan Sharp‐Bucknall, Tim Alexander Schubert, Jacob Johny, John‐Tommes Krzeslack, Walid Hetaba, Walter Leitner, Alexis Bordet   +7 more
wiley   +2 more sources

Design, Synthesis and Antihyperglycemic/Antilipidemic Activities of Quinoline-thiazolidine-2,4-dione Hybrid. [PDF]

Pharmaceuticals (Basel)
Abousaada EAM, Galal-Khallaf A, Mohammed-Geba K, El-Bahnsawye M, Hussein MKA, Elmongy EI, Shaltout RAA, Binsuwaidan R, Ali H, El-Tantawy AI, Abdel-Bary H, Tantawy El Sayed IE.   +11 more
europepmc   +1 more source

Chemoproteomic discovery of a brain‐penetrant, covalent NLRP3 inhibitor that binds a novel allosteric pocket

British Journal of Pharmacology, Volume 183, Issue 22, Page 6718-6734, November 2026.
NLRP3 is a promising inflammatory target, but existing inhibitors lack diversity and brain penetrance, and none are approved. Using chemoproteomics, we discovered a novel series that binds to Cys463 in a previously uncharacterized pocket. Compounds showed nanomolar potency, brain exposure, and in vivo suppression of IL‐1β, supporting neuroinflammatory ...
Donald C. Rogness, Evelyn P. Sievert, Vincent F. Vartabedian, Steffen M. Bernard, Erick Aitchison, William Tao, Mikaela Lindvall, Jing Qian, Christie L. Eissler, Brian E. Nordin, Benjamin D. Horning, Cian Kingston, Kelsey N. Lamb, Joshua C. Bell, Bingwen Lu, Jonathan Pollock, Jun Shi, Roli Khattri, David S. Weinstein, Matthew P. Patricelli, Brian N. Cook, Gabriel M. Simon   +21 more
wiley   +1 more source