Results 111 to 120 of about 56,164 (276)

From nature to nanoscale: advances, challenges, and preclinical translation of nanofiber drug delivery systems containing plant‐derived active ingredients

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Since the early 1960s, nanotechnology has been a critical area of science, allowing for the development of sophisticated nanomaterials. Nanofibers, one of the most widely used nanotechnological drug delivery systems, have emerged as a highly versatile platform within modern pharmaceutical sciences.
Heybet Kerem Polat, Yasin Turanlı, Nihat Kurt, Sefa Gözcü, Emre Tunçel, Hilal Bacanak, Eren Aytekin, Sedat Ünal   +7 more
wiley   +1 more source

QUINOLINE DERIVATIVES. PART IV.

, 1937
In view of the fact that glyoxatinoquinolines of Narang and Räy have the requisite antiseptic properties against paramaecia, benziminazolyIquinoline derivatives, which are expected to possess antimalarial properties, have been ...
openaire   +6 more sources

Transformation of indole and quinoline by Desulfobacterium indolicum (DSM 3383)

, 1996
Degradation of indole and quinoline by Desulfobacterium indolicum was studied in batch cultures. The first step in the degradation pathway of indole and quinoline was a hydroxylation at the 2 position to oxindole and 2-hydroxyquinoline respectively ...
Arvin, E., Licht, D., Johansen, S.S., Ahring, B.K.   +3 more
core   +1 more source

Harnessing Aggregation‐Induced Emission for Advanced Disease Diagnosis: Mechanisms, Strategies and Future Perspectives

Medicine Bulletin, EarlyView.
The figure was created in BioRender.com. ABSTRACT Accurate and early diagnosis remains a key challenge in modern disease management. Conventional diagnostic methods often suffer from limitations in sensitivity, spatial resolution, and practical usability.
Zizhuo Du, Li Song, Xingrui Chen, Jun Jing, Yingchen Wang, Yue Jiang, Jiahui Gao, Dan Li, Feiran Xie, Peihong Xiao, Ben Zhong Tang   +10 more
wiley   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Heteropolyanions: Soluble precatalysts for quinoline hydrogenation

, 1992
Initial efforts to evaluate heteropolyanions as potential precatalysts for quinoline hydrogenation are described. Reaction parameters are developed that define a baseline for quinoline hydrogenation to tetrahydroquinoline through exploration of the ...
Hoppe, M. L., Koo, Sang-Man, Ryan, D., Laine, R. M.   +3 more
core   +1 more source

Green and traditional one-pot synthesis techniques for bioactive quinoline derivatives: A review

Tetrahedron Green Chem
The review examines one-pot strategies and their mechanistic approaches for synthesizing the quinoline nucleus from 2009 to 2024, with a focus on their therapeutic potential.
Manav C. Parmar, Bonny Y. Patel
doaj   +1 more source

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Epothilone analogues with benzimidazole and quinoline side chains: chemical synthesis, antiproliferative activity, and interactions with tubulin

, 2009
A series of epothilone B and D analogues bearing isomeric quinoline or functionalized benzimidazole side chains has been prepared by chemical synthesis in a highly convergent manner.
Karl‐Heinz Altmann, Notararigo, Sara, Lindauer, Renate, Renate Lindauer, Stierling, Claire, Altmann, Karl-Heinz, Sara Notararigo, José Fernando Díaz, Gertsch, Jürg, Jürg Gertsch, Matesanz, Ruth, Ruth Matesanz, Dietrich, Silvia Anthoine, Díaz, José Fernando, Silvia Anthoine Dietrich, Stierlin, Claire, Claire Stierlin   +16 more
core   +1 more source

Targeting Human Immunodeficiency Virus Integrase Beyond the Active Site: The Discovery and Development of Allosteric Integrase Inhibitors. [PDF]

ChemMedChem
Human immunodeficiency virus (HIV) allosteric integrase inhibitors (ALLINIs) offer a vital alternative to standard therapies by targeting noncatalytic sites. By inducing aberrant integrase multimerization, they disrupt viral maturation. This review explores their medicinal chemistry evolution, detailing structural insights, structure–activity ...
Saccoliti F, Patacchini E, Cara E, Zarbo L, Messore A, Albano A, Ruggieri G, Madia VN, Scipione L, Costi R, Di Santo R.   +10 more
europepmc   +2 more sources