Results 111 to 120 of about 5,015,403 (283)
, 1951 The field under review is growing so rapidly that it is impossible to cover more than a sampling of recent papers in the allotted space. Important subjects such as the genetics and chemistry of viruses and certain topics in bacterial genetics have had ...
Horowitz, N. H., Mitchell, H. K.
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Serum Proteomic and Metabolomic Signatures of High Versus Low Physical Function in Octogenarians
Aging Cell, Volume 24, Issue 5, May 2025.Circulating factors are strongly implicated in modulating biological aging. In this study we show that the serum proteomic and metabolomic profile of high functioning octogenarians suggests lower activation of SASP, preservation of the tryptophan‐kynurenic pathway, higher lipophosphatidyl cholines promoting mitochondrial function, and reduced ...
Ceereena Ubaida‐Mohien +11 more
wiley +1 more source
The role of the cerebellum in drug-cue associative memory: functional interactions with the medial prefrontal cortex [PDF]
, 2018 Drug-induced Pavlovian memories are thought to be crucial for drug addiction because they guide behaviour towards environments with drug availability. Drug-related memory depends on persistent changes in dopamine-glutamate interactions in the medial pre-
Carbó Gas, María +4 more
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Acta Physiologica, Volume 241, Issue 5, May 2025.Abstract Aim Recent pre‐clinical evidence suggests that the tryptophan metabolite 3‐hydroxyanthranilic acid (3‐HAA) and the related enzyme activity along the kynurenine metabolic pathway (KP) are associated with lifespan extension. We aimed to translate these findings into humans and expose exercise training as a potential non‐pharmacological ...
Niklas Joisten +10 more
wiley +1 more source
A pro-convulsive carbamazepine metabolite: Quinolinic acid in drug resistant epileptic human brain
Neurobiology of Disease, 2012 Drugs and their metabolites often produce undesirable effects. These may be due to a number of mechanisms, including biotransformation by P450 enzymes which are not exclusively expressed by hepatocytes but also by endothelial cells in brain from ...
Chaitali Ghosh +7 more
doaj
Salivary Cytokines in Healthy Adolescent Girls: Intercorrelations, Stability, and Associations with Serum Cytokines, Age and Pubertal Stage. [PDF]
, 2013 Theoretically, the measurement of cytokines in saliva may have utility for studies of brain, behavior, and immunity in youth. Cytokines in saliva and serum were analyzed across three annual assessments in healthy adolescent girls (N = 114, 11-17 years at
Beal, SJ +7 more
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Some New Derivatives of Organozirconium(IV) with Pyridinedicarboxylic Acids
E-Journal of Chemistry, 2012 Reactions of dichlorobis(cyclopentadienyl)zirconium(IV) with pyridinedicarboxylic acids viz. quinolinic acids (QAH2), 2,4-pyridine dicarboxylic acid (PAH2), isocinchomeronic acid (IAH2), cinchomeronic acid (CAH2) and dinicotinic acid (DAH2) were carried ...
Satish C. Dixit, Rohit K. Singh
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The Isotropic Fractionator as a Tool for Quantitative Analysis in Central Nervous System Diseases [PDF]
, 2016 One major aim in quantitative and translational neuroscience is to achieve a precise and fast neuronal counting method to work on high throughput scale to obtain reliable results.Here we tested the Isotropic Fractionator (IF) method for evaluating ...
Alessandro Vercelli +7 more
core +2 more sources
Cell Transplantation, 2013 Huntington's disease (HD) produces severe neurodegeneration in the striatum leading to disabling motor impairments, including the loss of control of skilled reaching movements.
Alexander Klein +2 more
doaj +1 more source
Journal of Neuroinflammation, 2014 The excitotoxin quinolinic acid, a by-product of the kynurenine pathway, is known to be involved in several neurological diseases including multiple sclerosis (MS). Quinolinic acid levels are elevated in experimental autoimmune encephalomyelitis rodents,
Gayathri Sundaram +5 more
semanticscholar +1 more source