The excitotoxin quinolinic acid induces tau phosphorylation in human neurons.
PLoS ONE, 2009 Some of the tryptophan catabolites produced through the kynurenine pathway (KP), and more particularly the excitotoxin quinolinic acid (QA), are likely to play a role in the pathogenesis of Alzheimer's disease (AD).
Abdur Rahman +5 more
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The mysterious case of the C. elegans gut granule: death fluorescence, anthranilic acid and the kynurenine pathway [PDF]
, 2013 Gut granules are lysosome-like organelles with acidic interiors that are found in large numbers within the intestine of the nematode Caenorhabditis elegans.
Coburn, C, Gems, D
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Cell Transplantation, 2013 Huntington's disease (HD) produces severe neurodegeneration in the striatum leading to disabling motor impairments, including the loss of control of skilled reaching movements.
Alexander Klein +2 more
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Hyperammonemia-induced toxicity for the developing central nervous system [PDF]
, 2007 In pediatric patients, hyperammonemia can be caused by various acquired or inherited disorders such as urea cycle deficiencies or organic acidemias. The brain is much more susceptible to the deleterious effects of ammonium during development than in ...
Braissant, O., Cagnon, L.
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P4‐035: Quinolinic acid in HIV‐1‐associated dementia with pathogenetic processes distinct from Alzheimer disease [PDF]
, 2011 Wei Wu +6 more
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Increase in Alzheimer's related markers preceeds memory disturbances: Studies in vasopressin-deficient Brattleboro rat [PDF]
, 2014 Alzheimer's disease (AD) is the most common form of dementia in the elderly. For more effective therapy early diagnostic markers could be beneficial. Therefore we compared one year old rats with adults and examined if changes in possible brain markers of
Bagdy, György +12 more
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Evidence that quinolinic acid severely impairs energy metabolism through activation of NMDA receptors in striatum from developing rats [PDF]
, 2006 César Augusto João Ribeiro +4 more
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Excitotoxic degeneration of hypothalamic orexin neurons in slice culture
Neurobiology of Disease, 2004 Several lines of evidence indicate that narcolepsy, a sleep disorder, results from the loss of hypothalamic orexin (hypocretin)-containing neurons, but the mechanisms responsible for selective elimination of this neuronal population are unknown.
Hiroshi Katsuki, Akinori Akaike
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Vitamin B, Relative Nutritive Value and Palatability of Germinated Com (Zea mays L.) 1 [PDF]
, 1979 Changes in the riboflavin, niacin, thiamin and Relative Nutritive Value (RNV) in germinated com were studied. The corn were germinated for four days at 30°C and then dried at 50°C and ground. The vitamins were analysed by microbiological methods. The RNV
Fields, Marion L., Hashim, Normah
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