Research progress on the kynurenine pathway in the prevention and treatment of Parkinson’s disease
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Parkinson’s disease (PD) is characterised by progressive death of dopamine (DA) neurons in the substantia nigra pars compacta (SNpc) and pathological accumulation of α-synuclein fibrils, as well as central nervous system inflammation.
Ping Chen, Xiaofei Geng
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Determination of Dipyrone in pharmaceutical preparations based on the chemiluminescent reaction of the quinolinic hydrazide-H2O2-vanadium (IV) system and flow injection analysis [PDF]
, 2011 A rapid, economic and sensitive chemiluminescent method involving flow-injection analysis was developed for the determination of dipyrone in pharmaceutical preparations.
Durand Alegría, Jesús Senén +3 more
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Kynurenine 3-Monooxygenase: An Influential Mediator of Neuropathology [PDF]
, 2015 Mounting evidence demonstrates that kynurenine metabolism may play an important pathogenic role in the development of multiple neurological and neuropsychiatric disorders.
Jason C. O’Connor, Jennifer M. Parrott
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Current Evidence for a Role of the Kynurenine Pathway of Tryptophan Metabolism in Multiple Sclerosis [PDF]
, 2016 The kynurenine pathway (KP) is the major metabolic pathway of the essential amino acid tryptophan (TRP). Stimulation by inflammatory molecules, such as interferon-γ (IFN-γ), is the trigger for induction of the KP, driving a complex cascade of production ...
Bianca Varney +10 more
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Hydrogen sulfide reduces oxidative stress in Huntington’s disease via Nrf2
Neural Regeneration ResearchThe pathophysiology of Huntington’s disease involves high levels of the neurotoxin quinolinic acid. Quinolinic acid accumulation results in oxidative stress, which leads to neurotoxicity. However, the molecular and cellular mechanisms by which quinolinic
Zige Jiang +9 more
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Biomédica: revista del Instituto Nacional de Salud, 2018 The serotonergic and immunological hypothesis of depression proposes that certain types of excessive stress distort the relationship between the activities of the innate immune and central nervous systems, so that the stress caused by an infection, or ...
Leslie Alejandra Ramírez +5 more
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Letter to the editor: autoimmune pathogenic mechanisms in Huntington’s disease [PDF]
, 2018 Letter to the Editor: Autoimmune pathogenic mechanisms in Huntington's ...
DE VINCENTIIS, Marco +5 more
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Advanced Science, EarlyView.4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang +7 more
wiley +1 more source
The Influence of Kynurenine and Its Metabolites on Lipid Metabolism
Pteridines, 1997 Incorporation of fatty acids into phospholipids has been investigated using samples of rat liver tissue homogenate, Krebs-Ringer-phosphate buffer (pH=7.4) containing 0.3% albumin, fatty acid mixture and glycerol.
Rudzite Vera +6 more
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Improved Synthesis of N-Substituted Quinolinimides Using Microwave Irradiation
Molecules, 2000 The synthesis of several quinolinimidoacetic acid derivatives (I) by two different routes, starting from quinolinic anhydride or quinolinimide, is described.
M. M. Blanco +2 more
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