Results 21 to 30 of about 8,617 (174)
Phytochemical treatments target kynurenine pathway induced oxidative stress
Redox Report, 2018 Objective: The objective of this paper was to link the phytochemical and metabolic research treating quinolinic acid induced oxidative stress in neurodegenerative disorders.
K. Parasram
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Kynurenines in the Pathogenesis of Multiple Sclerosis: Therapeutic Perspectives
Cells, 2020 Over the past years, an increasing amount of evidence has emerged in support of the kynurenine pathway’s (KP) pivotal role in the pathogenesis of several neurodegenerative, psychiatric, vascular and autoimmune diseases.
Tamás Biernacki +3 more
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Frontiers in Immunology, 2023 There is an increasing interest in the pathophysiological role of the kynurenine pathway of tryptophan metabolism in the regulation of immune function and inflammation.
Arduino A. Mangoni +2 more
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PLoS ONE, 2013 To assess the role of the kynurenine pathway in the pathology of Alzheimer's disease (AD), the expression and localization of key components of the kynurenine pathway including the key regulatory enzyme tryptophan 2,3 dioxygenase (TDO), and the ...
Wei Wu +9 more
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Microglial Dysregulation and Suicidality: A Stress-Diathesis Perspective
Frontiers in Psychiatry, 2020 According to the stress-diathesis model of suicidal behavior, completed suicide depends on the interaction between psychosocial stressors and a trait-like susceptibility.
Paria Baharikhoob +7 more
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Research progress on the kynurenine pathway in the prevention and treatment of Parkinson’s disease
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Parkinson’s disease (PD) is characterised by progressive death of dopamine (DA) neurons in the substantia nigra pars compacta (SNpc) and pathological accumulation of α-synuclein fibrils, as well as central nervous system inflammation.
Ping Chen, Xiaofei Geng
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A pro-convulsive carbamazepine metabolite: Quinolinic acid in drug resistant epileptic human brain
Neurobiology of Disease, 2012 Drugs and their metabolites often produce undesirable effects. These may be due to a number of mechanisms, including biotransformation by P450 enzymes which are not exclusively expressed by hepatocytes but also by endothelial cells in brain from ...
Chaitali Ghosh +7 more
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Hydrogen sulfide reduces oxidative stress in Huntington’s disease via Nrf2
Neural Regeneration ResearchThe pathophysiology of Huntington’s disease involves high levels of the neurotoxin quinolinic acid. Quinolinic acid accumulation results in oxidative stress, which leads to neurotoxicity. However, the molecular and cellular mechanisms by which quinolinic
Zige Jiang +9 more
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Biomédica: revista del Instituto Nacional de Salud, 2018 The serotonergic and immunological hypothesis of depression proposes that certain types of excessive stress distort the relationship between the activities of the innate immune and central nervous systems, so that the stress caused by an infection, or ...
Leslie Alejandra Ramírez +5 more
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Advanced Science, EarlyView.Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu +18 more
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