Quinolinic acid toxicity on oligodendroglial cells: relevance for multiple sclerosis and therapeutic strategies [PDF]
, 2014 © Sundaram et al.; licensee BioMed Central. The excitotoxin quinolinic acid, a by-product of the kynurenine pathway, is known to be involved in several neurological diseases including multiple sclerosis (MS).
Bruce J Brew +11 more
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Quinolinic acid, the inescapable neurotoxin [PDF]
The FEBS Journal, 2012 Over the last two decades, evidence for the involvement of quinolinic acid (QUIN) in neuroinflammatory diseases has been exponentially increasing. Within the brain, QUIN is produced and released by infiltrating macrophages and activated microglia, the very cells that are prominent during neuroinflammation.
openaire +2 more sources
Phytochemical treatments target kynurenine pathway induced oxidative stress
Redox Report, 2018 Objective: The objective of this paper was to link the phytochemical and metabolic research treating quinolinic acid induced oxidative stress in neurodegenerative disorders.
K. Parasram
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Kynurenines in the Pathogenesis of Multiple Sclerosis: Therapeutic Perspectives
Cells, 2020 Over the past years, an increasing amount of evidence has emerged in support of the kynurenine pathway’s (KP) pivotal role in the pathogenesis of several neurodegenerative, psychiatric, vascular and autoimmune diseases.
Tamás Biernacki +3 more
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Frontiers in Immunology, 2023 There is an increasing interest in the pathophysiological role of the kynurenine pathway of tryptophan metabolism in the regulation of immune function and inflammation.
Arduino A. Mangoni +2 more
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PLoS ONE, 2013 To assess the role of the kynurenine pathway in the pathology of Alzheimer's disease (AD), the expression and localization of key components of the kynurenine pathway including the key regulatory enzyme tryptophan 2,3 dioxygenase (TDO), and the ...
Wei Wu +9 more
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Discrete quinolinic acid lesions of the lateral but not of the medial caudate putamen reversed haloperidol-induced catalepsy in rats [PDF]
, 2014 Discrete lesions in the medial or lateral subregion of the rostral caudate-putamen (CP) were induced by bilateral intracerebral injections of a low dose of quinolinic acid (30 nmol in 1 mgrl/per side) in rats.
Schmidt, Werner J., Hauber, Wolfgang
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Microglial Dysregulation and Suicidality: A Stress-Diathesis Perspective
Frontiers in Psychiatry, 2020 According to the stress-diathesis model of suicidal behavior, completed suicide depends on the interaction between psychosocial stressors and a trait-like susceptibility.
Paria Baharikhoob +7 more
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Research progress on the kynurenine pathway in the prevention and treatment of Parkinson’s disease
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Parkinson’s disease (PD) is characterised by progressive death of dopamine (DA) neurons in the substantia nigra pars compacta (SNpc) and pathological accumulation of α-synuclein fibrils, as well as central nervous system inflammation.
Ping Chen, Xiaofei Geng
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The Endogenous Tryptophan Metabolite and NAD(+) Precursor Quinolinic Acid Confers Resistance of Gliomas to Oxidative Stress [PDF]
, 2013 Quinolinic acid is a product of tryptophan degradation and may serve as a precursor for NAD(+), an important enzymatic cofactor for enzymes such as the DNA repair protein PARP.
Bode, H. +10 more
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