Results 11 to 20 of about 2,693,323 (214)

Hesperidin Plays Neuroprotective Effects Against Quinolinic Acid in Human SH-SY5Y Cells: Focusing on ROS Levels and Cell Cycle Arrest [PDF]

Research Journal of Pharmacognosy
Background and objectives: In some neurodegenerative diseases, an aberrant accumulation of quinolinic acid is frequently associated with the loss of nerve cells and a condition known as neuritis.
Farzaneh Abbasinezhad-Moud, Emad Azimi, Mehdi Rostami, Elaheh Gheybi, Mohammad Soukhtanloo*   +4 more
doaj   +3 more sources

Quinolinic Acid: Neurotoxin or Oxidative Stress Modulator? [PDF]

International Journal of Molecular Sciences, 2013
Quinolinic acid (2,3-pyridinedicarboxylic acid, QUIN) is a well-known neurotoxin. Consequently, QUIN could produce reactive oxygen species (ROS). ROS are generated in reactions catalyzed by transition metals, especially iron (Fe). QUIN can form coordination complexes with iron.
Lenka Kubicova, Franz Hadacek, Vladimir Chobot   +2 more
core   +7 more sources

Quinolinic Acid Responses during Interferon-α-Induced Depressive Symptomatology in Patients with Chronic Hepatitis C Infection - A Novel Aspect for Depression and Inflammatory Hypothesis.

PLoS ONE, 2015
BackgroundThe aim of this exploratory study is to gain for the first time a more comprehensive picture of the impact of changes of quinolinic acid concentrations on depressive symptomatology during and after IFN-α therapy.MethodsThe quinolinic acid ...
Andreas Baranyi, Andreas Meinitzer, Robert J Breitenecker, Omid Amouzadeh-Ghadikolai, Rudolf Stauber, Hans-Bernd Rothenhäusler   +5 more
doaj   +2 more sources

Crystal structure of N-[2-(cyclohexylsulfanyl)ethyl]quinolinic acid imide

Acta Crystallographica Section E: Crystallographic Communications, 2017
The title compound, C15H18N2O2S {systematic name: 6-[2-(cyclohexylsulfanyl)ethyl]-5H-pyrrolo[3,4-b]pyridine-5,7(6H)-dione}, was obtained from the reaction of pyridine-2,3-dicarboxylic anhydride (synonym: quinolinic anhydride) with 2-(cyclohexylsulfanyl ...
Hyunjin Park, Myong Yong Choi, Cheol Joo Moon, Tae Ho Kim   +3 more
doaj   +2 more sources

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Transplantation of induced pluripotent stem cells improves functional recovery in Huntington's disease rat model. [PDF]

PLoS ONE, 2014
The purpose of this study was to determine the functional recovery of the transplanted induced pluripotent stem cells in a rat model of Huntington's disease with use of 18F-FDG microPET/CT imaging.In a quinolinic acid-induced rat model of striatal ...
Shuhua Mu, Jiachuan Wang, Guangqian Zhou, Wenda Peng, Zhendan He, Zhenfu Zhao, CuiPing Mo, Junle Qu, Jian Zhang   +8 more
doaj   +1 more source

“Kynurenine switch” and obesity

Бюллетень сибирской медицины, 2022
Aim. To assess the concentrations of bacterial and eukaryotic metabolites mainly involved in indole, kynurenine, and serotonin pathways of tryptophan metabolism in a cohort of patients with obesity. Materials and methods.
A. V. Shestopalov, O. P. Shatova, M. S. Karbyshev, A. M. Gaponov, N. E. Moskaleva, S. A. Appolonova, A. V. Tutelyan, V. V. Makarov, S. M. Yudin, S. A. Roumiantsev   +9 more
doaj   +1 more source

M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection. [PDF]

PLoS ONE, 2012
Indoleamine 2,3-dioxygenesae-1 (IDO-1) catalyses the initial, rate-limiting step in tryptophan metabolism, thereby regulating tryptophan availability and the formation of downstream metabolites, including picolinic and quinolinic acid.
Antje Blumenthal, Gayathri Nagalingam, Jennifer H Huch, Lara Walker, Gilles J Guillemin, George A Smythe, Sabine Ehrt, Warwick J Britton, Bernadette M Saunders   +8 more
doaj   +1 more source

Accumulation of Quinolinic Acid Modulates the Pulmonary Immune Response During Influenza Infection. [PDF]

Int J Tryptophan Res
Influenza viruses cause a highly contagious, acute pulmonary disease that results in significant mortality each year. These infections trigger the production of interferons, known to induce the expression of the rate-limiting enzyme in the kynurenine ...
Pamart G, Hennart B, Ollivier A, Kervoaze G, Pichavant M, Gosset P, Le Rouzic O, Poulain-Godefroy O.   +7 more
europepmc   +2 more sources

Methods of preparation and biological activity of quinolinic acid and derivatives [PDF]

, 2003
In 1981 2,3-pyridine dicarboxylic acid (quinolinic acid) was discovery to be a selective agonist for the N-methyl -D-aspartic acid (NMDA) receptor.
Amarante, Giovanni Wilson, Almeida, Mauro Vieira de, Cardoso, Sílvia Helena, Souza, Marcus Vinícius Nora de, Hyaric, Mireille Le   +4 more
core   +1 more source