Quinolinic acid, the inescapable neurotoxin [PDF]
The FEBS Journal, 2012 Over the last two decades, evidence for the involvement of quinolinic acid (QUIN) in neuroinflammatory diseases has been exponentially increasing. Within the brain, QUIN is produced and released by infiltrating macrophages and activated microglia, the very cells that are prominent during neuroinflammation.
Gilles Guillemin
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Metabolic engineering of Escherichia coli for quinolinic acid production by assembling L-aspartate oxidase and quinolinate synthase as an enzyme complex. [PDF]
Metab Eng, 2021 Zhu F, Peña M, Bennett GN.
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Abnormal Activation of Tryptophan-Kynurenine Pathway in Women With Polycystic Ovary Syndrome
Frontiers in Endocrinology, 2022 BackgroundWomen with polycystic ovary syndrome (PCOS) suffer from dysfunctional metabolism and studies have reported increased levels of tryptophan in patients with PCOS.
Siyu Wang +25 more
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Synthesis of some new substituted imines from aldehydes and ketones derived from quinolinic acid
Eclética Química, 2023 In this paper, some substituted imines compounds have been prepared from quinolinic acid as a starting material. Firstly, the quinolinic acid was treated with acetic anhydride and acetic acid to form furo[3,4-b]pyridine-5,7-dione (1); the resulting ...
Anwar Abdulghani Fathi +2 more
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Transplantation of induced pluripotent stem cells improves functional recovery in Huntington's disease rat model. [PDF]
PLoS ONE, 2014 The purpose of this study was to determine the functional recovery of the transplanted induced pluripotent stem cells in a rat model of Huntington's disease with use of 18F-FDG microPET/CT imaging.In a quinolinic acid-induced rat model of striatal ...
Shuhua Mu +8 more
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“Kynurenine switch” and obesity
Бюллетень сибирской медицины, 2022 Aim. To assess the concentrations of bacterial and eukaryotic metabolites mainly involved in indole, kynurenine, and serotonin pathways of tryptophan metabolism in a cohort of patients with obesity. Materials and methods.
A. V. Shestopalov +9 more
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Quinolinic Acid: Neurotoxin or Oxidative Stress Modulator? [PDF]
International Journal of Molecular Sciences, 2013 Quinolinic acid (2,3-pyridinedicarboxylic acid, QUIN) is a well-known neurotoxin. Consequently, QUIN could produce reactive oxygen species (ROS). ROS are generated in reactions catalyzed by transition metals, especially iron (Fe). QUIN can form coordination complexes with iron.
Lenka Kubicova +2 more
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M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection. [PDF]
PLoS ONE, 2012 Indoleamine 2,3-dioxygenesae-1 (IDO-1) catalyses the initial, rate-limiting step in tryptophan metabolism, thereby regulating tryptophan availability and the formation of downstream metabolites, including picolinic and quinolinic acid.
Antje Blumenthal +8 more
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Hesperidin Plays Neuroprotective Effects Against Quinolinic Acid in Human SH-SY5Y Cells: Focusing on ROS Levels and Cell Cycle Arrest [PDF]
Research Journal of PharmacognosyBackground and objectives: In some neurodegenerative diseases, an aberrant accumulation of quinolinic acid is frequently associated with the loss of nerve cells and a condition known as neuritis.
Farzaneh Abbasinezhad-Moud +4 more
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The kynurenine pathway as a therapeutic target in cognitive and neurodegenerative disorders [PDF]
, 2013 Understanding the neurochemical basis for cognitive function is one of the major goals of neuroscience, with a potential impact on the diagnosis, prevention and treatment of a range of psychiatric and neurological disorders.
Akagbosu +172 more
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