Results 31 to 40 of about 2,693,323 (214)
A pro-convulsive carbamazepine metabolite: Quinolinic acid in drug resistant epileptic human brain
Neurobiology of Disease, 2012 Drugs and their metabolites often produce undesirable effects. These may be due to a number of mechanisms, including biotransformation by P450 enzymes which are not exclusively expressed by hepatocytes but also by endothelial cells in brain from ...
Chaitali Ghosh +7 more
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, 2015 The tryptophan metabolite, quinolinic (2,3-pyridinedicarboxylic) acid, is known as an endogenous neurotoxin. Quinolinic acid can form coordination complexes with iron or copper.
Weckwerth, Wolfram +3 more
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, 1998 Injection of the excitatory amino-acid analog quinolinic acid into the striatum of rats produces neuropathological and neurochemical alterations that are reminiscent of those observed in Huntington's disease. In the present study, we evaluated quinolinic
Levivier, M., Przedborski, S.
core +2 more sources
Hydrogen sulfide reduces oxidative stress in Huntington’s disease via Nrf2
Neural Regeneration ResearchThe pathophysiology of Huntington’s disease involves high levels of the neurotoxin quinolinic acid. Quinolinic acid accumulation results in oxidative stress, which leads to neurotoxicity. However, the molecular and cellular mechanisms by which quinolinic
Zige Jiang +9 more
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Quinolinic acid: neurotoxicity [PDF]
The FEBS Journal, 2012 This minireview series reviews some of the most recent findings about quinolinic acid's cellular toxicity and its implications in diseases such as HIV associated neurocognitive disorders, depressive disorders and schizophrenia, and finally therapeutic strategies with drugs able to interfere with quinolinic acid production and/or effects.
openaire +1 more source
Melatonin neutralizes neurotoxicity induced by quinolinic acid in brain tissue culture
, 2005 Quinolinic acid is a well-known excitotoxin that induces oxidative stress and damage. In the present study, oxidative damage to biomolecules was followed by measuring lipid peroxidation and protein carbonyl formation in rat brain tissue culture over a ...
Tomás-Zapico, Cristina +8 more
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Improved Synthesis of N-Substituted Quinolinimides Using Microwave Irradiation
Molecules, 2000 The synthesis of several quinolinimidoacetic acid derivatives (I) by two different routes, starting from quinolinic anhydride or quinolinimide, is described.
M. M. Blanco +2 more
doaj +1 more source
Advanced Science, EarlyView.ABSTRACT Autism Spectrum Disorder (ASD) is associated with gut microbiota dysbiosis, yet the contribution of specific microbial metabolic pathways remains unclear. Reanalysis of a public ASD cohort revealed reduced functional potential in microbial tryptophan oxidative metabolism.
Rui Guo +14 more
wiley +1 more source
Biomédica: revista del Instituto Nacional de Salud, 2018 The serotonergic and immunological hypothesis of depression proposes that certain types of excessive stress distort the relationship between the activities of the innate immune and central nervous systems, so that the stress caused by an infection, or ...
Leslie Alejandra Ramírez +5 more
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Advanced Science, EarlyView.ProMetNet introduces a biologically constrained deep learning framework for proteo‐metabolomic integration by embedding Reactome‐derived pathway topology into neural networks. It captures non‐linear molecular dependencies and pathway‐level metabolic reorganization, enabling interpretable discrimination.
Minghui Zhao +6 more
wiley +1 more source