PLoS ONE, 2013 To assess the role of the kynurenine pathway in the pathology of Alzheimer's disease (AD), the expression and localization of key components of the kynurenine pathway including the key regulatory enzyme tryptophan 2,3 dioxygenase (TDO), and the ...
Wei Wu +9 more
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Frontiers in Immunology, 2023 There is an increasing interest in the pathophysiological role of the kynurenine pathway of tryptophan metabolism in the regulation of immune function and inflammation.
Arduino A. Mangoni +2 more
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Microglial Dysregulation and Suicidality: A Stress-Diathesis Perspective
Frontiers in Psychiatry, 2020 According to the stress-diathesis model of suicidal behavior, completed suicide depends on the interaction between psychosocial stressors and a trait-like susceptibility.
Paria Baharikhoob +7 more
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Research progress on the kynurenine pathway in the prevention and treatment of Parkinson’s disease
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Parkinson’s disease (PD) is characterised by progressive death of dopamine (DA) neurons in the substantia nigra pars compacta (SNpc) and pathological accumulation of α-synuclein fibrils, as well as central nervous system inflammation.
Ping Chen, Xiaofei Geng
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It takes two to tango: NAD+ and sirtuins in aging/longevity control [PDF]
, 2016 The coupling of nicotinamide adenine dinucleotide (NAD+) breakdown and protein deacylation is a unique feature of the family of proteins called ‘sirtuins.’ This intimate connection between NAD+ and sirtuins has an ancient origin and provides a ...
Guarente, Leonard, Imai, Shin-ichiro
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Quinolinic acid selectively induces apoptosis of human astrocytes: potential role in AIDS dementia complex [PDF]
, 2005 There is evidence that the kynurenine pathway (KP) and particularly one of its end products, quinolinic acid (QUIN) play a role in the pathogenesis of several major neuroinflammatory diseases, and more particularly AIDS dementia complex (ADC).
Gilles J Guillemin +2 more
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Urinary N-methylnicotinamide and β-aminoisobutyric acid predict catch-up growth in undernourished Brazilian children [PDF]
, 2015 Enteric infections, enteropathy and undernutrition in early childhood are preventable risk factors for child deaths, impaired neurodevelopment, and later life metabolic diseases.
Guerrant, RL +10 more
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Determination of Dipyrone in pharmaceutical preparations based on the chemiluminescent reaction of the quinolinic hydrazide-H2O2-vanadium (IV) system and flow injection analysis [PDF]
, 2011 A rapid, economic and sensitive chemiluminescent method involving flow-injection analysis was developed for the determination of dipyrone in pharmaceutical preparations.
Durand Alegría, Jesús Senén +3 more
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A pro-convulsive carbamazepine metabolite: Quinolinic acid in drug resistant epileptic human brain
Neurobiology of Disease, 2012 Drugs and their metabolites often produce undesirable effects. These may be due to a number of mechanisms, including biotransformation by P450 enzymes which are not exclusively expressed by hepatocytes but also by endothelial cells in brain from ...
Chaitali Ghosh +7 more
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Kynurenine 3-Monooxygenase: An Influential Mediator of Neuropathology [PDF]
, 2015 Mounting evidence demonstrates that kynurenine metabolism may play an important pathogenic role in the development of multiple neurological and neuropsychiatric disorders.
Jason C. O’Connor, Jennifer M. Parrott
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