Research progress on the kynurenine pathway in the prevention and treatment of Parkinson’s disease
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Parkinson’s disease (PD) is characterised by progressive death of dopamine (DA) neurons in the substantia nigra pars compacta (SNpc) and pathological accumulation of α-synuclein fibrils, as well as central nervous system inflammation.
Ping Chen, Xiaofei Geng
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The Endogenous Tryptophan Metabolite and NAD(+) Precursor Quinolinic Acid Confers Resistance of Gliomas to Oxidative Stress [PDF]
, 2013 Quinolinic acid is a product of tryptophan degradation and may serve as a precursor for NAD(+), an important enzymatic cofactor for enzymes such as the DNA repair protein PARP.
Bode, H. +10 more
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A pro-convulsive carbamazepine metabolite: Quinolinic acid in drug resistant epileptic human brain
Neurobiology of Disease, 2012 Drugs and their metabolites often produce undesirable effects. These may be due to a number of mechanisms, including biotransformation by P450 enzymes which are not exclusively expressed by hepatocytes but also by endothelial cells in brain from ...
Chaitali Ghosh +7 more
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Vagus Nerve Stimulation in Refractory Epilepsy: Effects on Pro- and Anti-Inflammatory Cytokines in Peripheral Blood [PDF]
, 2010 Objective: The vagus nerve has important immunological functions that may be relevant for its anticonvulsive action. We postulate that this anticonvulsive action is activated by a shift in the immune system resulting in a reduction of neurotoxic and an ...
J.S.H. Vles +15 more
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Hydrogen sulfide reduces oxidative stress in Huntington’s disease via Nrf2
Neural Regeneration ResearchThe pathophysiology of Huntington’s disease involves high levels of the neurotoxin quinolinic acid. Quinolinic acid accumulation results in oxidative stress, which leads to neurotoxicity. However, the molecular and cellular mechanisms by which quinolinic
Zige Jiang +9 more
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Effects of endogenous neurotoxin quinolinic acid on reactive oxygen species production by Fenton reaction catalyzed by iron or copper [PDF]
, 2015 The tryptophan metabolite, quinolinic (2,3-pyridinedicarboxylic) acid, is known as an endogenous neurotoxin. Quinolinic acid can form coordination complexes with iron or copper.
Weckwerth, Wolfram +3 more
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Quinolinic acid: neurotoxicity [PDF]
The FEBS Journal, 2012 This minireview series reviews some of the most recent findings about quinolinic acid's cellular toxicity and its implications in diseases such as HIV associated neurocognitive disorders, depressive disorders and schizophrenia, and finally therapeutic strategies with drugs able to interfere with quinolinic acid production and/or effects.
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, 2003 NADP is essential for biosynthetic pathways, energy, and signal transduction. In living organisms, NADP biosynthesis proceeds through the phosphorylation of NAD with a reaction catalyzed by NAD kinase.
Menico Rizzi +7 more
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Methods of preparation and biological activity of quinolinic acid and derivatives [PDF]
, 2003 In 1981 2,3-pyridine dicarboxylic acid (quinolinic acid) was discovery to be a selective agonist for the N-methyl -D-aspartic acid (NMDA) receptor.
Amarante, Giovanni Wilson +5 more
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Biomédica: revista del Instituto Nacional de Salud, 2018 The serotonergic and immunological hypothesis of depression proposes that certain types of excessive stress distort the relationship between the activities of the innate immune and central nervous systems, so that the stress caused by an infection, or ...
Leslie Alejandra Ramírez +5 more
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