Results 71 to 80 of about 9,006 (217)

Plasma neurofilament light chain and amyloid-β are associated with the kynurenine pathway metabolites in preclinical Alzheimer’s disease

Journal of Neuroinflammation, 2019
Background Blood markers indicative of neurodegeneration (neurofilament light chain; NFL), Alzheimer’s disease amyloid pathology (amyloid-β; Aβ), and neuroinflammation (kynurenine pathway; KP metabolites) have been investigated independently in ...
Pratishtha Chatterjee, Henrik Zetterberg, Kathryn Goozee, Chai K. Lim, Kelly R. Jacobs, Nicholas J. Ashton, Abdul Hye, Steve Pedrini, Hamid R. Sohrabi, Tejal Shah, Prita R. Asih, Preeti Dave, Kaikai Shen, Kevin Taddei, David B. Lovejoy, Gilles J. Guillemin, Kaj Blennow, Ralph N. Martins   +17 more
doaj   +1 more source

Investigation of the Impact of Tryptophan‐Metabolizing Enzymes and Kynurenic Acid on Antibody‐Mediated Glomerulonephritis

The FASEB Journal, Volume 39, Issue 18, 30 September 2025.
The graphical abstract illustrates that Ido1 deficiency exacerbates antibody‐mediated glomerulonephritis through enhanced neutrophil activation, whereas kynurenic acid suppresses neutrophil spreading, FcγR–Syk signaling, and VEGF release, thereby protecting against glomerular injury.
Ryosuke Umeda, Yoshimasa Ito, Shun Minatoguchi, Shigehisa Koide, Kazuo Takahashi, Hiroki Hayashi, Midori Hasegawa, Yukio Yuzawa, Yasuko Yamamoto, Kuniaki Saito, Naotake Tsuboi   +10 more
wiley   +1 more source

Pyridinedicarboxylic Acid Derivatives of Dichlorobis(cyclopentadienyl)titanium(IV)

E-Journal of Chemistry, 2012
Reactions of dichlorobis(cyclopentadienyl)titanium(IV) with pyridine dicarboxylic acids viz. quinolinic acid (QAH2), 2,4-pyridine dicarboxylic acid (PAH2), isocinchomeronic acid (IAH2), cinchomeronic acid (CAH2) and dinicotinic acid (DAH2) were carried ...
Satish C. Dixit, Rohit K. Singh
doaj   +1 more source

Immunometabolism: The role of gut‐derived microbial metabolites in optimising immune response during checkpoint inhibitor therapy

Clinical and Translational Medicine, Volume 15, Issue 9, September 2025.
Unique metabolic signatures are associated with both response and resistance to cancer immunotherapy. These signatures can be used to predict response to treatment and in the future, metabolites could potentially be used to enhance specific types of immune response associated with favourable immunological outcomes. Abstract Checkpoint inhibitor therapy
Agnieszka Beata Malczewski, Jermaine Ig Coward, Natkunam Ketheesan, Severine Navarro   +3 more
wiley   +1 more source

Seasonal Plasticity in Tryptophan Metabolism Provides New Insights Into Physiological Adaptation in Snake Hibernation

Ecology and Evolution, Volume 15, Issue 9, September 2025.
The microbial pathways of tryptophan metabolism predominate in active snakes, while the 5‐hydroxytryptamine pathway and kynurenine pathway govern tryptophan catabolism in hibernating snakes. ABSTRACT Hibernation is a common behavioral strategy for snakes to cope with extreme environments.
Yuting Wei, Zexiu Zhang, Xiaohong Lin, Gangning Wei, Pengyue Zhang, Huirong Mao, Biao Chen, Jianhao Ji, Yunlin Zheng, Zhiyi Luo, Xiaolong Hu   +10 more
wiley   +1 more source

Alterations and mechanistic insights of gut microbiota and its metabolites in type 2 diabetes mellitus and Alzheimer's disease

iMetaOmics, Volume 2, Issue 3, September 2025.
This narrative review uniquely addresses how gut microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, and amyloidogenesis in type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), proposing a framework for dual therapeutic targeting.
Guangyi Xu, Yu An, Yage Du, Zhaoming Cao, Jie Zheng, Jingya Wang, Tingyi Li, Xingen Lei, Yanhui Lu   +8 more
wiley   +1 more source

Serotonin (5‐Hydroxytryptamine): Metabolism, Signaling, Biological Functions, Diseases, and Emerging Therapeutic Opportunities

MedComm, Volume 6, Issue 9, September 2025.
This article reviews the roles of 5‐HT metabolism, 5‐HT receptors, and their related signaling pathways in normal physiology and various diseases, and explores their potential value in disease treatment, providing a reference basis for research and clinical treatment in related fields. ABSTRACT Serotonin (5‐hydroxytryptamine; 5‐HT) is an evolutionarily
Yuxin Zhang, Nan Wang, Louqian Zhang, Yan Zhuang, Qilei Xin, Xiaosong Gu, Chunping Jiang, Junhua Wu   +7 more
wiley   +1 more source

Some New Derivatives of Organozirconium(IV) with Pyridinedicarboxylic Acids

E-Journal of Chemistry, 2012
Reactions of dichlorobis(cyclopentadienyl)zirconium(IV) with pyridinedicarboxylic acids viz. quinolinic acids (QAH2), 2,4-pyridine dicarboxylic acid (PAH2), isocinchomeronic acid (IAH2), cinchomeronic acid (CAH2) and dinicotinic acid (DAH2) were carried ...
Satish C. Dixit, Rohit K. Singh
doaj   +1 more source

The excitotoxin quinolinic acid induces tau phosphorylation in human neurons.

PLoS ONE, 2009
Some of the tryptophan catabolites produced through the kynurenine pathway (KP), and more particularly the excitotoxin quinolinic acid (QA), are likely to play a role in the pathogenesis of Alzheimer's disease (AD).
Abdur Rahman, Kaka Ting, Karen M Cullen, Nady Braidy, Bruce J Brew, Gilles J Guillemin   +5 more
doaj   +1 more source

Brain Repair in a Unilateral Rat Model of Huntington's Disease: New Insights into Impairment and Restoration of Forelimb Movement Patterns

Cell Transplantation, 2013
Huntington's disease (HD) produces severe neurodegeneration in the striatum leading to disabling motor impairments, including the loss of control of skilled reaching movements.
Alexander Klein, Emma L. Lane, Stephen B. Dunnett   +2 more
doaj   +1 more source