Results 11 to 20 of about 1,525 (166)

Evaluation of the Alterations in Central Cholinergic Neurotransmission in Aging and Amyloid Precursor Protein Knock-In Mice. [PDF]

J Neurochem
In Alzheimer's disease, reduced release of ACh is linked more to Aβ pathology than to age‐related change, highlighting an early sign of disease. ABSTRACT A progressive decline in cognitive function occurs as a result of aging and Alzheimer's disease (AD) and is primarily associated with diminished cholinergic neurotransmission.
Nagai-Arakawa I, Muramatsu I, Uwada J, Tsuda Y, Tokunaga A, Irie A, Maeda H, Madokoro Y, Sato T, Uchida Y, Saito T, Saido TC, Sada K, Masuoka T, Matsukawa N.   +14 more
europepmc   +2 more sources

Pharmacological and molecular characterization of the A‐type muscarinic acetylcholine receptor from Anopheles gambiae

Insect Molecular Biology, Volume 31, Issue 4, Page 497-507, August 2022., 2022
A‐type mAChR was identified in Anopheles gambiae larvae and adult mosquitoes Activation of An. gambiae mAChR‐A which is coupled to phosphoinositide pathway induced intracellular calcium increase An. gambiae mAChR‐A is mainly blocked by 4‐DAMP known as M3 mAChR antagonist in mammals Summary showing the pharmacology of Anopheles gambiae mAChR‐A and its ...
Alexandre Pilon, Delphine Goven, Valerie Raymond   +2 more
wiley   +1 more source

Spatial Covariance of Cholinergic Muscarinic M1/M4 Receptors in Parkinson's Disease

Movement Disorders, Volume 36, Issue 8, Page 1879-1888, August 2021., 2021
ABSTRACT Background Parkinson's disease (PD) is associated with cholinergic dysfunction, although the role of M1 and M4 receptors remains unclear. Objective To investigate spatial covariance patterns of cholinergic muscarinic M1/M4 receptors in PD and their relationship with cognition and motor symptoms.
Sean J. Colloby, Pradeep J. Nathan, Geor Bakker, Rachael A. Lawson, Alison J. Yarnall, David J. Burn, John T. O'Brien, John‐Paul Taylor   +7 more
wiley   +1 more source

Convulsant bicuculline modifies CNS muscarinic receptor affinity

BMC Neuroscience, 2006
Background Previous work from this laboratory has shown that the administration of the convulsant drug 3-mercaptopropionic acid (MP), a GAD inhibitor, modifies not only GABA synthesis but also binding of the antagonist [3H]-quinuclidinyl benzilate ([3H ...
Rodríguez de Lores Arnaiz Georgina, Schneider Patricia G   +1 more
doaj   +1 more source

A detailed parameter study into the dermal absorption of chemical warfare agents and the effects of pharmacokinetics [PDF]

, 2022
Chemical warfare agents (CWAs) are substances of varying toxicity profiles. These chemicals exhibit complex dynamics and pose a serious health risk when released into the environment.
Lear, Koko
core   +1 more source

Evaluation of the Pichia pastoris expression system for the production of GPCRs for structural analysis

Microbial Cell Factories, 2011
Background Various protein expression systems, such as Escherichia coli (E. coli), Saccharomyces cerevisiae (S. cerevisiae), Pichia pastoris (P. pastoris), insect cells and mammalian cell lines, have been developed for the synthesis of G protein-coupled ...
Sugawara Taishi, Ito Keisuke, Tsujimoto Hirokazu, Shimamura Tatsuro, Shiroishi Mitsunori, Yurugi-Kobayashi Takami, Uemura Tomoko, Asada Hidetsugu, Nakane Takanori, Nomura Norimichi, Murata Takeshi, Haga Tatsuya, Iwata So, Kobayashi Takuya   +13 more
doaj   +1 more source

Decreased binding capacity (Bmax) of muscarinic acetylcholine receptors in fibroblasts from boys with attention-deficit/hyperactivity disorder (ADHD). [PDF]

Atten Defic Hyperact Disord, 2013
Johansson J, Landgren M, Fernell E, Lewander T, Venizelos N.   +4 more
europepmc   +3 more sources

NEMS Resonators for Detection of Chemical Warfare Agents Based on Graphene Sheet

Mathematical Problems in Engineering, Volume 2019, Issue 1, 2019., 2019
Graphene sheets are the basis of nanoelectromechanical (NEMS) mass resonators that are in recent years experimentally used for detection of specific gas molecules in air. The aim of this paper is to theoretically investigate the possibility of application of graphene sheets in detection of Chemical Warfare Agents (CWA’s). By application of the nonlocal
Nikola Anđelić, Zlatan Car, Marko Čanađija, Xiao-Qiao He   +3 more
wiley   +1 more source

Neurotoxicity [PDF]

, 2014
Neurotoxicity refers to the direct or indirect effect of chemicals that disrupt the nervous system of humans or animals. Numerous chemicals can produce neurotoxic diseases in humans, and many more are used as experimental tools to disturb or damage the ...
Brust, Creeley, Feldman, Grandjean, Herken, Panzica, Parent, Pessah, Rice, Román, Spencer, Spencer, Tu, Vinken, Yasui, Zawia   +15 more
core   +2 more sources

Serum Anticholinergic Activity: A Possible Peripheral Marker of the Anticholinergic Burden in the Central Nervous System in Alzheimer’s Disease

Disease Markers, Volume 2014, Issue 1, 2014., 2014
We review the utility of serum anticholinergic activity (SAA) as a peripheral marker of anticholinergic activity (AA) in the central nervous system (CAA). We hypothesize that the compensatory mechanisms of the cholinergic system do not contribute to SAA if their system is intact and that if central cholinergic system deteriorates alone in conditions ...
Koji Hori, Kimiko Konishi, Masayuki Tani, Hiroi Tomioka, Ryo Akita, Yuka Kitajima, Mari Aoki, Sachiko Yokoyama, Kazunari Azuma, Daisuke Ikuse, Norihisa Akashi, Misa Hosoi, Koichi Jinbo, Mitsugu Hachisu, Esperanza Ortega   +14 more
wiley   +1 more source