Results 21 to 30 of about 1,525 (166)

A photoisomerizable muscarinic antagonist. Studies of binding and of conductance relaxations in frog heart [PDF]

, 1982
These experiments employ the photoisomerizable compound, 3,3'-bis- [alpha-(trimethylammonium)methyl]azobenzene (Bis-Q), to study the response to muscarinic agents in frog myocardium. In homogenates from the heart, trans-Bis-Q blocks the binding of [3H]-N-
Birdsall, Nigel J. M., Erlanger, Bernard F., Lester, Henry A., Nargeot, Joel, Stockton, Jane, Wassermann, Norbert H.   +5 more
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Synthesis and In Vitro Evaluation of Novel Nortropane Derivatives as Potential Radiotracers for Muscarinic M2 Receptors

International Journal of Molecular Imaging, Volume 2011, Issue 1, 2011., 2011
Disturbances of the cerebral cholinergic neurotransmitter system are present in neurodegenerative disorders. SPECT or PET imaging, using radiotracers that selectively target muscarinic receptor subtypes, may be of value for in vivo evaluation of such conditions.
Remco J. J. Knol, Jan C. van den Bos, Anton G. M. Janssen, Kora de Bruin, Berthe L. F. van Eck-Smit, Jan Booij, Guy Bormans   +6 more
wiley   +1 more source

Strains of Rodents and the Pharmacology of Learning and Memory

Neural Plasticity, Volume 11, Issue 3-4, Page 205-216, 2004., 2004
Mendelian genetic tools have extensively been used to improve the description of the pharmacological mechanisms involved in learning and memory. The first part of this short review describes experiments involving the bidirectional selection of rats or mice for extreme behavioral characteristics or for sensitivity to pharmacological treatments.
Martine Ammassari-Teule, Claudio Castellano   +1 more
wiley   +1 more source

Toxicological Profile of Aluminium Sulphate and Effect on Protein Profile in Albino Rat [PDF]

, 2018
World is full of xenobiotic substances such as heavy metal, pesticide and other pollutic agents. Heavy metal is a metallic element of relatively high density greater than 4gm/cm3 or 5 times more greater than water and is toxic even at low concentration ...
Singh, P. K. (P), Upadhyay, N. (Neelam), Yadav, R. (Reena)   +2 more
core   +3 more sources

Effect of Cissampelos capensis rhizome extract on human spermatozoa in vitro [PDF]

, 2014
Cissampelos capensis is commonly known by the Afrikaans name ‘dawidjies’ or ‘dawidjieswortel’. C. capensis is the most important and best-known medicinal plant of the family Menispermaceae used by the Khoisan and other rural people in the western regions
Erasmus, N., Henkel, Ralf, Shalaweh, Salem, Weitz, Frans   +3 more
core   +1 more source

The acetylcholine index: an electroencephalographic marker of cholinergic activity in the living human brain applied to Alzheimer's disease and other dementias. [PDF]

, 2014
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files.
Gudmundsson, Thorkell Eli, Johannesson, Gisli Holmar, Johannsson, Magnus, Johnsen, Kristinn, Snaedal, Jon   +4 more
core   +1 more source

Nitric oxide-mediated cortical activation: a diffuse wake-up system [PDF]

, 2003
Nitric oxide (NO) has been implicated in some of the central pathways engaged in the regulation of the sleep–wake cycle. The existence of nitric oxide synthase (NOS) in the cholinergic basal forebrain (BF) cells projecting to the cortex suggests a role ...
Cudeiro Mazaira, Francisco Javier, Mariño Alfonso, Xurxo   +1 more
core   +2 more sources

ANALYSIS AND IDENTIFICATION SPIKING CHEMICAL COMPOUNDS RELATED TO CHEMICAL WEAPON CONVENTION IN UNKNOWN WATER SAMPLES USING GAS CHROMATOGRAPHY AND GAS CHROMATOGRAPHY ELECTRON IONIZATION MASS SPECTROMETRY [PDF]

, 2010
The identification and analysis of chemical warfare agents and their degradation products is one of important component for the implementation of the convention.
Harry Budiman
core   +2 more sources

Molecular determinants of allosteric modulation at the M1 muscarinic acetylcholine receptor [PDF]

, 2014
Background: BQCA is a selective allosteric modulator of the M1 mAChR. Results: Residues that govern BQCA activity were identified using mutagenesis and molecular modelling.
Abdul-Ridha, Avlani, Ballesteros, Black, Canals, Cherezov, Choe, Christopoulos, Conn, Conn, Daval, Davie, De Amici, Dror, Duan, Goodwin, Haga, Huang, Hulme, Hulme, Kenakin, Kruse, Lagerström, Leach, Leach, Leach, Lebois, Lebon, Lu, Lu, Ma, Marquer, Matsui, May, May, Miao, Mistry, Motulsky, Nawaratne, Nawaratne, Phillips, Prilla, Rasmussen, Rasmussen, Sali, Shirey, Shonberg, Spalding, Stevens, Tan, Thompson, Valant, Valant, Valentin-Hansen, Venkatakrishnan, Voigtländer, Wacker, Wang   +57 more
core   +2 more sources

Targeting muscarinic receptors for the treatment of alcohol use disorders: Opportunities and hurdles for clinical development

British Journal of Pharmacology, Volume 181, Issue 22, Page 4385-4398, November 2024.
Emerging evidence suggests muscarinic acetylcholine receptors represent novel targets to treat alcohol use disorder. In this review, we draw from literature across medicinal chemistry, molecular biology, addiction and learning/cognition fields to interrogate the proposition for muscarinic receptor ligands in treating various aspects of alcohol use ...
Leigh C. Walker, Kade L. Huckstep, Howard C. Becker, Christopher J. Langmead, Andrew J. Lawrence   +4 more
wiley   +1 more source