Video didàctic i article d'anàlisi de resultats per a una pràctica de laboratori : estudi dels receptors colinèrgics muscarínics mitjançant tècniques de fixació de radiolligands (binding) [PDF]
, 2006 El concepte d'equilibri químic és difícil de transmetre correctament als estudiants tant de cursos bàsics com avançats, una situació que queda ben reflectida en la frase d'en FM Harold: "El problema de les coses senzilles és que s'han d'entendre molt bé".
Claro Izaguirre, Enrique
core
Quantifying conformational changes in GPCRs : glimpse of a common functional mechanism [PDF]
, 2015 Background: G-protein-coupled receptors (GPCRs) are important drug targets and a better understanding of their molecular mechanisms would be desirable.
Dalton, James A. R +2 more
core +3 more sources
In vitro and ex vivo evaluation of cyclic aminoalkyl benzilates as potential emission tomography ligands for the muscarinic receptor [PDF]
, 1989 A series of muscarinic antagonists were screened as potential receptor imaging agents. (+)2[alpha]-tropanyl benzilate (TRB), N-methyl-4-piperidyl benzilate (NMPB) and several analogs amenable to labeling with positron emitting isotopes were evaluated for
Combs, R. +5 more
core +1 more source
Synthesis of the Alzheimer drug Posiphen into its primary metabolic products (+)-N1-norPosiphen, (+)-N8-norPosiphen and (+)-N1, N8-bisnorPosiphen, their inhibition of amyloid precursor protein, α-Synuclein synthesis, interleukin-1β release, and cholinergic action [PDF]
, 2013 A major pathological hallmark of Alzheimer disease (AD) is the appearance in the brain of senile plaques that are primarily composed of aggregated forms of β-amyloid peptide (Aβ) that derive from amyloid precursor protein (APP).
Greig, Nigel H. +9 more
core
The UK's Search for an Incapacitating ('Non-Lethal') Chemical Agent in the 1960s [PDF]
, 2006 Ye
Dando, Malcolm R.
core
Evaluation of quaternized and neutral muscarinic receptor ligands in normal and DES-treated rat [PDF]
, 1991 The localization of quaternized muscarinic receptor (mAChR) antagonists, [11C]methyl tropanyl benzilate ([11C]MTRB) and [11C]methyl quinuclidinyl benzilate ([11C]MQNB), in rat pituitary was compared to that of [11C]tropanyl benzilate ([11C]TRB), a ...
Demattos, S. B. +5 more
core +1 more source
Chick brain cholinergic receptors studied by antagonist labelling: distribution, ontogeny & function [PDF]
, 1988 By means of an in vitro labelling technique and methods of light microscope autoradiography the distribution of/muscarinic cholinergic receptor, labelled L by the tritiated antagonists I-Quinuclidinyl benzilate or Propylbenzilylcholine mustard, and the ...
Coulter, John Christopher
core +1 more source
A pszichokémiai fegyverek kutatási programja a Magyar Népköztársaságban (1962-1972) [PDF]
, 2009 A Magyar Királyság a II. Világháború során ambiciózus biofegyver-fejlesztési programot működtetett, mely a háború végén megsemmisült. A program újraindítására tett erőfeszítések 1955-ben nem jártak sikerrel, vélhetően azért, mert a Szovjetunió ...
Rózsa, Lajos
core
On Resilient Behaviors in Computational Systems and Environments
, 2015 The present article introduces a reference framework for discussing resilience of computational systems. Rather than a property that may or may not be exhibited by a system, resilience is interpreted here as the emerging result of a dynamic process. Said
A Brandenburger +10 more
core +1 more source
The Role of B-Arrestin in Agonish-Induced Down-Regulation of the M1 mAChR [PDF]
, 2006 Wilham, Laura E., M.S., December 2006 Pharmaceutical Sciences THE ROLE OF â–ARRESTIN IN AGONIST-INDUCED DOWN-REGULATION OF THE M1 mAChR Chair: Darrell A.
Wilham, Laura Elizabeth
core +1 more source