Results 111 to 120 of about 25,588 (204)

Exosome‐Enhanced Injectable Hydrogels: A Comprehensive Review on Their Emerging Role in Wound Healing

Health Science Reports, Volume 9, Issue 1, January 2026.
ABSTRACT Background and Aims The escalation of chronic wounds necessitates advanced therapeutic strategies beyond current interventions. Hydrogel dressings, particularly injectable hydrogels, offer promising solutions due to their water absorption capacity, structural resilience, and ease of application.
Mohammad Ebrahim Astaneh, Lalji Baldaniya, Abhayveer Singh, Ahmad Hussen, Alireza Hashemzadeh, Narges Fereydouni   +5 more
wiley   +1 more source

Defective axonal transport in motor neuron disease [PDF]

, 2007
Several recent studies have highlighted the role of axonal transport in the pathogenesis of motor neuron diseases. Mutations in genes that control microtubule regulation and dynamics have been shown to cause motor neuron degeneration in mice and in a ...
Baas, Blair, Boillee, Bommel, Borchelt, Bowling, Brown, Bruijn, Burger, Cao, Cleveland, Cleveland, Duchen, Escurat, Evans, Fichera, Fliegner, Gaudette, Goldstein, Hadano, Hafezparast, Hazan, Hirokawa, Hirokawa, Hirokawa, Jablonka, Joshi, Kanai, Kaplan, Kieran, King, Kong, LaMonte, Levy, Ligon, Liu, Lo Giudice, Lu, Martin, Miki, Miki, Mitsumoto, Mitsumoto, Muglia, Munch, Nicholson, Nishimura, Okabe, Otomo, Parkinson, Parysek, Pasinelli, Patel, Proukakis, Puls, Puls, Quenneville, Rao, Reid, Reid, Reid, Rosen, Ross, Rowland, Sanderson, Schmitt-John, Shaw, Shibata, Siegel, Song, Teuchert, Troy, Vallee, Weber, Williamson, Wood, Xia, Zhao   +77 more
core   +1 more source

Rab-GTPase binding effector protein 2 (RABEP2) is a primed substrate for Glycogen Synthase kinase-3 (GSK3) [PDF]

, 2017
Glycogen synthase kinase-3 (GSK3) regulates many physiological processes through phosphorylation of a diverse array of substrates. Inhibitors of GSK3 have been generated as potential therapies in several diseases, however the vital role GSK3 plays in ...
A Cole, A Russo, A Zeigerer, AR Cole, C Gao, C Hooper, D Finlay, DG Campbell, DP Hanger, E Beurel, GW Cline, H Gournier, J Zhou, JE Gray, JL Lucitti, K MacAulay, KP Hoeflich, L Avrahami, L Kockeritz, M Medina, MM Bradford, P Cohen, P Cohen, PH Sugden, PT Ly, R Airik, RS Jope, RS Jope, S Haq, S Renzis de, VF Taelman   +30 more
core   +4 more sources

Rab5 Induces Rac-independent Lamellipodia Formation and Cell Migration

Molecular Biology of the Cell, 1999
Rab5 is a regulatory GTPase of vesicle docking and fusion that is involved in receptor-mediated endocytosis and pinocytosis. Introduction of active Rab5 in cells stimulates the rate of endocytosis and vesicle fusion, resulting in the formation of large endocytic vesicles, whereas dominant negative Rab5 inhibits vesicle fusion.
Spaargaren, M., Bos, J. L.
openaire   +4 more sources

The Rab5 effector Rabankyrin-5 regulates and coordinates different endocytic mechanisms.

PLoS Biology, 2004
The small GTPase Rab5 is a key regulator of clathrin-mediated endocytosis. On early endosomes, within a spatially restricted domain enriched in phosphatydilinositol-3-phosphate [PI(3)P], Rab5 coordinates a complex network of effectors that functionally ...
Carsten Schnatwinkel, Savvas Christoforidis, Margaret R Lindsay, Sandrine Uttenweiler-Joseph, Matthias Wilm, Robert G Parton, Marino Zerial   +6 more
doaj   +1 more source

Rab5 isoforms orchestrate a "division of labor" in the endocytic network; Rab5C modulates Rac-mediated cell motility.

PLoS ONE, 2014
Rab5, the prototypical Rab GTPase and master regulator of the endocytic pathway, is encoded as three differentially expressed isoforms, Rab5A, Rab5B and Rab5C.
Pin-I Chen, Kristine Schauer, Chen Kong, Andrew R Harding, Bruno Goud, Philip D Stahl   +5 more
doaj   +1 more source

Endocytic recycling and vesicular transport systems mediate transcytosis of Leptospira interrogans across cell monolayer. [PDF]

, 2019
Many bacterial pathogens can cause septicemia and spread from the bloodstream into internal organs. During leptospirosis, individuals are infected by contact with Leptospira-containing animal urine-contaminated water.
Fang, Jia-Qi, Hu, Wei-Lin, Li, Kai-Xuan, Li, Shi-Jun, Li, Yang, Lin, Xu'ai, Ojcius, David M, Yan, Jie   +7 more
core   +1 more source

Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. [PDF]

, 2012
Our understanding of Alzheimer's disease pathogenesis is currently limited by difficulties in obtaining live neurons from patients and the inability to model the sporadic form of the disease.
Bardy, Cedric, Boscolo, Francesca S, Carson, Christian T, Gage, Fred H, Goldstein, Lawrence SB, Hefferan, Michael P, Herrera, Cheryl, Israel, Mason A, Koo, Edward H, Laurent, Louise C, Marsala, Martin, Mu, Yangling, Nazor, Kristopher L, Remes, Anne M, Reyna, Sol M, Van Gorp, Sebastiaan, Yuan, Shauna H   +16 more
core   +3 more sources

CIN85 phosphorylation is essential for EGFR ubiquitination and sorting into multivesicular bodies [PDF]

, 2012
Ubiquitination of the epidermal growth factor receptor (EGFR) by cbl and its cognate adaptor cbl-interacting protein of 85 kDa (CIN85) is known to play an essential role in directing this receptor to the lysosome for degradation.
Billadeau, Daniel, McNiven, Mark A, Schroeder, Barbara, Shaw, Andrey, Srivatsan, Subhashini   +4 more
core   +2 more sources

Biogenesis of the Sorting Endosome: The Role of Rab5 [PDF]

Traffic, 2000
Rab5 is a regulatory guanosine triphosphatase that is associated with the sorting endosome and participates in endosomal membrane fusion reactions. Recent experiments have provided insights into Rab5 function by demonstrating direct links between Rab5‐interacting proteins and components of the membrane fusion apparatus.
openaire   +2 more sources