Flipping the Switch: Next‐Generation Chemo‐Optogenetics for Reversible Control of Biological Systems
ChemPhotoChem, Volume 10, Issue 3, March 2026.Next‐generation chemo‐optogenetic systems use photoswitchable molecular glues for reversible, repeatable light control of protein proximity, enabling precise spatiotemporal modulation of signaling, organelle dynamics, and protein stability—opening avenues for in vivo studies and therapeutic applications.
Laura K. Herzog, Jun Zhang, Yao‐Wen Wu
wiley +1 more source
Specific recycling receptors are targeted to the immune synapse by the intraflagellar transport system [PDF]
, 2014 T cell activation requires sustained signaling at the immune synapse (IS), a specialized interface with the APC that assembles following TCR engagement by MHC-bound peptide.
Baldari +44 more
core +1 more source
Endocytic recycling and vesicular transport systems mediate transcytosis of Leptospira interrogans across cell monolayer. [PDF]
, 2019 Many bacterial pathogens can cause septicemia and spread from the bloodstream into internal organs. During leptospirosis, individuals are infected by contact with Leptospira-containing animal urine-contaminated water.
Fang, Jia-Qi +7 more
core +1 more source
Regulation of Rab5 Function during Phagocytosis of Live Pseudomonas aeruginosa in Macrophages [PDF]
, 2013 Pseudomonas aeruginosa, a Gram-negative opportunistic human pathogen, is a frequent cause of severe hospital-acquired infections. Effectors produced by the type III secretion system disrupt mammalian cell membrane trafficking and signaling and are ...
Barbieri, M Alejandro +4 more
core +2 more sources
Rab5 Induces Rac-independent Lamellipodia Formation and Cell Migration
Molecular Biology of the Cell, 1999 Rab5 is a regulatory GTPase of vesicle docking and fusion that is involved in receptor-mediated endocytosis and pinocytosis. Introduction of active Rab5 in cells stimulates the rate of endocytosis and vesicle fusion, resulting in the formation of large endocytic vesicles, whereas dominant negative Rab5 inhibits vesicle fusion.
Spaargaren, M., Bos, J. L.
openaire +4 more sources
Reduction criterion for separability [PDF]
, 1999 We introduce a separability criterion based on the positive map Γ:ρ→(Tr ρ)-ρ, where ρ is a trace-class Hermitian operator. Any separable state is mapped by the tensor product of Γ and the identity into a non-negative operator, which provides a simple ...
Adami, C., Cerf, N. J., Gingrich, R. M.
core +1 more source
The Rab5 effector Rabankyrin-5 regulates and coordinates different endocytic mechanisms.
PLoS Biology, 2004 The small GTPase Rab5 is a key regulator of clathrin-mediated endocytosis. On early endosomes, within a spatially restricted domain enriched in phosphatydilinositol-3-phosphate [PI(3)P], Rab5 coordinates a complex network of effectors that functionally ...
Carsten Schnatwinkel +6 more
doaj +1 more source
PLoS ONE, 2014 Rab5, the prototypical Rab GTPase and master regulator of the endocytic pathway, is encoded as three differentially expressed isoforms, Rab5A, Rab5B and Rab5C.
Pin-I Chen +5 more
doaj +1 more source
Turing instabilities in a mathematical model for signaling networks
, 2011 GTPase molecules are important regulators in cells that continuously run through an activation/deactivation and membrane-attachment/membrane-detachment cycle. Activated GTPase is able to localize in parts of the membranes and to induce cell polarity.
AB Goryachev +27 more
core +1 more source
Rab-GTPase binding effector protein 2 (RABEP2) is a primed substrate for Glycogen Synthase kinase-3 (GSK3) [PDF]
, 2017 Glycogen synthase kinase-3 (GSK3) regulates many physiological processes through phosphorylation of a diverse array of substrates. Inhibitors of GSK3 have been generated as potential therapies in several diseases, however the vital role GSK3 plays in ...
A Cole +30 more
core +4 more sources