Results 121 to 130 of about 25,169 (206)

CIN85 phosphorylation is essential for EGFR ubiquitination and sorting into multivesicular bodies [PDF]

, 2012
Ubiquitination of the epidermal growth factor receptor (EGFR) by cbl and its cognate adaptor cbl-interacting protein of 85 kDa (CIN85) is known to play an essential role in directing this receptor to the lysosome for degradation.
Billadeau, Daniel, McNiven, Mark A, Schroeder, Barbara, Shaw, Andrey, Srivatsan, Subhashini   +4 more
core   +2 more sources

Critical role for Piccolo in synaptic vesicle retrieval

eLife, 2019
Loss of function of the active zone protein Piccolo has recently been linked to a disease, Pontocerebellar Hypoplasia type 3, which causes brain atrophy.
Frauke Ackermann, Kay Oliver Schink, Christine Bruns, Zsuzsanna Izsvák, F Kent Hamra, Christian Rosenmund, Craig Curtis Garner   +6 more
doaj   +1 more source

Biogenesis of the Sorting Endosome: The Role of Rab5 [PDF]

Traffic, 2000
Rab5 is a regulatory guanosine triphosphatase that is associated with the sorting endosome and participates in endosomal membrane fusion reactions. Recent experiments have provided insights into Rab5 function by demonstrating direct links between Rab5‐interacting proteins and components of the membrane fusion apparatus.
openaire   +2 more sources

Regulation of Liver Metabolism by the Endosomal GTPase Rab5

Cell Reports, 2015
The liver maintains glucose and lipid homeostasis by adapting its metabolic activity to the energy needs of the organism. Communication between hepatocytes and extracellular environment via endocytosis is key to such homeostasis. Here, we addressed the question of whether endosomes are required for gluconeogenic gene expression.
Zeigerer, Anja, Bogorad, Roman L., Sharma, Kirti, Gilleron, Jerome, Seifert, Sarah, Sales, Susanne, Berndt, Nikolaus, Bulik, Sascha, Marsico, Giovanni, D’Souza, Rochelle C.J., Lakshmanaperumal, Naharajan, Meganathan, Kesavan, Natarajan, Karthick, Sachinidis, Agapios, Dahl, Andreas, Holzhütter, Hermann-Georg, Shevchenko, Andrej, Mann, Matthias, Koteliansky, Victor, Zerial, Marino, Bogorad, Roman   +20 more
openaire   +8 more sources

Coordination between ESCRT function and Rab conversion during endosome maturation

The EMBO Journal
The endosomal pathway is essential for regulating cell signaling and cellular homeostasis. Rab5 positive early endosomes receive proteins from the plasma membrane.
Daniel P Ott, Samit Desai, Jachen A Solinger, Andres Kaech, Anne Spang   +4 more
doaj   +1 more source

Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5

eLife, 2014
Rabex-5 and Rabaptin-5 function together to activate Rab5 and further promote early endosomal fusion in endocytosis. The Rabex-5 GEF activity is autoinhibited by the Rabex-5 CC domain (Rabex-5CC) and activated by the Rabaptin-5 C2-1 domain (Rabaptin-5C21)
Zhe Zhang, Tianlong Zhang, Shanshan Wang, Zhou Gong, Chun Tang, Jiangye Chen, Jianping Ding   +6 more
doaj   +1 more source

The First Passage Probability of Intracellular Particle Trafficking

, 2009
The first passage probability (FPP), of trafficked intracellular particles reaching a displacement L, in a given time t or inverse velocity S = t/L, can be calculated robustly from measured particle tracks, and gives a measure of particle movement in ...
Arcizet, Bacher, Caspi, Coscoy, de bruin, Huet, Kahana, Miura, Neftali Flores-Rodriguez, Nielsen, Pangarkar, Petrov, Philip G. Woodman, Posta, Rogers, Salman S. Rogers, Savin, Suh, Thomas A. Waigh, Victoria J. Allan, Voliotis, Watts, Wen, Xu, Zaliapin   +24 more
core   +2 more sources

Changes in early endosomes in rat hippocampal CA1 neurons after transient global cerebral ischaemia

Folia Histochemica et Cytobiologica
INTRODUCTION: Transient global ischaemia in rodents causes selective loss of hippocampal CA1neurons, but the potential involvement of endocytic pathways has not been fully explored.
Min Qiang, Bai-Hong Tan, De-Sheng Huo, Shu-Lei Li, Zi-Zhen Fan, Ze-Qun Zhou, Rong-Yu Wang, Yanchao Li   +7 more
doaj   +1 more source

A new role for RAB5 [PDF]

Nature Reviews Molecular Cell Biology, 2011
openaire   +1 more source

Rabex-5 E3 and Rab5 GEF domains differ in their regulation of Ras, Notch, and PI3K signaling in Drosophila wing development.

PLoS ONE
Rabex-5 (also called RabGEF1), a protein originally characterized for its Rab5 GEF function, also has an A20-like E3 ubiquitin ligase domain. We and others reported that Rabex-5 E3 activity promotes Ras mono- and di-ubiquitination to inhibit Ras ...
Theresa A Reimels, Mia Steinberg, Hua Yan, Sivan Shahar, Ashley Rosenberg, Kristina Kalafsky, Max Luf, Lindsay Kelly, Stacia Octaviani, Cathie M Pfleger   +9 more
doaj   +1 more source