Results 11 to 20 of about 25,588 (204)

SPIN90, an adaptor protein, alters the proximity between Rab5 and Gapex5 and facilitates Rab5 activation during EGF endocytosis [PDF]

Experimental and Molecular Medicine, 2019
Intracellular transport: a new SPIN A key protein required for incorporating substances into cells has been identified by researchers in South Korea. During this process, called endocytosis, materials are engulfed by the cell membrane, then packaged into
Hwan Kim, Hyejin Oh, Young Soo Oh, Jeomil Bae, Nan Hyung Hong, Su Jung Park, Suyeon Ahn, Miriam Lee, Sangmyung Rhee, Sung Haeng Lee, Youngsoo Jun, Sung Hyun Kim, Yun Hyun Huh, Woo Keun Song   +13 more
doaj   +3 more sources

Patatin-domain-containing (phospho)lipases under control: Mammalian co-regulators and pathogenic activation mechanisms. [PDF]

FEBS Open Bio
Patatin domain‐containing (phospho)lipases are lipid‐hydrolyzing enzymes central to metabolism, membrane remodeling, and signaling. Their activity relies on precise co‐activation mechanisms involving protein–protein interactions and conformational rearrangements.
Dubey N, Riegler-Berket L, Oberer M.
europepmc   +2 more sources

rab5 GTPase Regulates Adenovirus Endocytosis [PDF]

Journal of Virology, 1999
ABSTRACT Adenovirus interaction with αv integrins is important for virus entry. We have examined the effects of adenovirus attachment on intracellular signaling in HeLa cells, with an emphasis on pathways known to be activated following integrin interaction with other ligands. We found no evidence for [Ca 2+
T, Rauma, J, Tuukkanen, J M, Bergelson, G, Denning, T, Hautala   +4 more
openaire   +2 more sources

Assessing Rab5 Activation in Health and Disease [PDF]

, 2021
The endocytic pathway is a system of dynamically communicating vesicles, known as early endosomes, that internalize, sort, and traffic nutrients, trophic factors, and signaling molecules to sites throughout the cell. In all eukaryotic cells, early endosome functions are regulated by Rab5 activity, dependent upon its binding to GTP, whereas Rab5 bound ...
Anna, Pensalfini, Ying, Jiang, Seonil, Kim, Ralph A, Nixon   +3 more
openaire   +2 more sources

Rab5-dependent autophagosome closure by ESCRT [PDF]

Journal of Cell Biology, 2019
In the conserved autophagy pathway, autophagosomes (APs) engulf cellular components and deliver them to the lysosome for degradation. Before fusing with the lysosome, APs have to close via an unknown mechanism. We have previously shown that the endocytic Rab5-GTPase regulates AP closure.
Fan Zhou, Zulin Wu, Mengzhu Zhao, Rakhilya Murtazina, Juan Cai, Ao Zhang, Rui Li, Dan Sun, Wenjing Li, Lei Zhao, Qunli Li, Jing Zhu, Xiaoxia Cong, Yixi Zhou, Zhiping Xie, Valeriya Gyurkovska, Liuju Li, Xiaoshuai Huang, Yanhong Xue, Liangyi Chen, Hui Xu, Haiqian Xu, Yongheng Liang, Nava Segev   +23 more
openaire   +2 more sources

Rab5 Association with the Angiotensin II Type 1A Receptor Promotes Rab5 GTP Binding and Vesicular Fusion [PDF]

Journal of Biological Chemistry, 2002
Previous studies have demonstrated that the internalization of the angiotensin II type 1A receptor (AT(1A)R) may be mediated by both beta-arrestin-sensitive and -insensitive mechanisms. Therefore, we have used the AT(1A)R carboxyl-terminal tail to screen a rat brain yeast two-hybrid expression library for novel AT(1A)R-interacting proteins that might ...
Jennifer L, Seachrist, Stephane A, Laporte, Lianne B, Dale, Andy V, Babwah, Marc G, Caron, Pieter H, Anborgh, Stephen S G, Ferguson   +6 more
openaire   +2 more sources

Identification of the Rab5 Binding Site in p110β: Assays for PI3Kβ Binding to Rab5 [PDF]

, 2015
Isoform-specific signaling by Class IA PI 3-kinases depends in part on the interactions between distinct catalytic subunits and upstream regulatory proteins. From among the class IA catalytic subunits (p110α, p110β, and p110δ), p110β has unique properties.
Rachel S, Salamon, Hashem A, Dbouk, Denise, Collado, Jaclyn, Lopiccolo, Anne R, Bresnick, Jonthan M, Backer   +5 more
openaire   +2 more sources

A non-linear system patterns Rab5 GTPase on the membrane

eLife, 2020
Proteins can self-organize into spatial patterns via non-linear dynamic interactions on cellular membranes. Modelling and simulations have shown that small GTPases can generate patterns by coupling guanine nucleotide exchange factors (GEF) to effectors ...
Alice Cezanne, Janelle Lauer, Anastasia Solomatina, Ivo F Sbalzarini, Marino Zerial   +4 more
doaj   +1 more source

The ubiquitous dermokine delta activates Rab5 function in the early endocytic pathway. [PDF]

PLoS ONE, 2011
The expression of the recently identified dermokine (Dmkn) gene leads to four families of proteins with as yet unknown functions. The secreted α, β and γ isoforms share an epidermis-restricted expression pattern, whereas the δ isoform is intracellular ...
Emilie A Leclerc, Leila Gazeilles, Guy Serre, Marina Guerrin, Nathalie Jonca   +4 more
doaj   +1 more source

Capping protein regulates endosomal trafficking by controlling F-actin density around endocytic vesicles and recruiting RAB5 effectors

eLife, 2021
Actin filaments (F-actin) have been implicated in various steps of endosomal trafficking, and the length of F-actin is controlled by actin capping proteins, such as CapZ, which is a stable heterodimeric protein complex consisting of α and β subunits ...
Dawei Wang, Zuodong Ye, Wenjie Wei, Jingting Yu, Lihong Huang, Hongmin Zhang, Jianbo Yue   +6 more
doaj   +1 more source