Results 21 to 30 of about 25,169 (206)
eLife, 2021 Actin filaments (F-actin) have been implicated in various steps of endosomal trafficking, and the length of F-actin is controlled by actin capping proteins, such as CapZ, which is a stable heterodimeric protein complex consisting of α and β subunits ...
Dawei Wang +6 more
doaj +1 more source
Rabaptin5 is recruited to endosomes by Rab4 and Rabex5 to regulate endosome maturation [PDF]
, 2015 Rab GTPases control membrane identity, fusion, and transport by interaction with effector proteins. Effectors that influence the activation/inactivation cycle of their own or other Rabs contribute to the timely conversion of Rab identities.
Buser, Dominik P. +3 more
core +1 more source
Coordination of the Rab5 Cycle on Macropinosomes [PDF]
Traffic, 2011 The GTPase Rab5a regulates the homotypic and heterotypic fusion of membranous organelles during the early stages of endocytosis. Many of the molecules which regulate the Rab5a cycle of association with membranes, activation, deactivation and dissociation are known.
Feliciano, William David +3 more
openaire +3 more sources
Integration of two RAB5 groups during endosomal transport in plants
eLife, 2018 RAB5 is a key regulator of endosomal functions in eukaryotic cells. Plants possess two different RAB5 groups, canonical and plant-unique types, which act via unknown counteracting mechanisms.
Emi Ito +6 more
doaj +1 more source
Effect of EGF-Receptor Tyrosine Kinase Inhibitor on Rab5 Function During Endocytosis [PDF]
, 2012 Tyrosine autophosphorylation within the cytoplasmic tail of EGF-receptor is a key event, which in turn recruits several factors including Shc, Grb2 and Rin1 that are essential activities for receptor-mediated endocytosis and signaling.
Barbieri, M. Alejandro +2 more
core +2 more sources
Rab GTPase Mediating Regulation of NALP3 in Colorectal Cancer
Molecules, 2020 The NALP3 inflammasome signaling contributes to inflammation within tumor tissues. This inflammation may be promoted by the vesicle trafficking of inflammasome components and cytokines. Rab5, Rab7 and Rab11 regulate vesicle trafficking. However, the role
Gülçin Tezcan +5 more
doaj +1 more source
Cell Communication and Signaling, 2021 Background CMTM7 is a tumor suppressor that positively regulates EGFR degradation by promoting Rab5 activation, and plays a vital role in tumor progression. Rab5 forms complexes with Beclin1 and VPS34, and acts in the early stage of autophagy.
Baocai Liu +7 more
doaj +1 more source
Construction of a Plasmodium falciparum Rab-interactome identifies CK1 and PKA as Rab-effector kinases in malaria parasites [PDF]
, 2011 Background information The pathology causing stages of the human malaria parasite Plasmodium falciparum reside within red blood cells that are devoid of any regulated transport system.
Bourdoncle, P. +9 more
core +1 more source
Rab5 GTPases are required for optimal TORC2 function [PDF]
Journal of Cell Biology, 2018 Target of rapamycin complex-2 (TORC2), a conserved protein kinase complex, is an indispensable regulator of plasma membrane homeostasis. In budding yeast (Saccharomyces cerevisiae), the essential downstream effector of TORC2 is protein kinase Ypk1 and its paralog Ypk2.
Melissa N. Locke, Jeremy Thorner
openaire +4 more sources
Abnormal α-synuclein interactions with rab3a and rabphilin in diffuse Lewy body disease
Neurobiology of Disease, 2004 The present study examines α-synuclein interactions with rab3a and rabphilin by antibody arrays, immunoprecipitation and pull-down methods in the entorhinal cortex of control cases and in diffuse Lewy body disease (LBD) cases.
E Dalfó +4 more
doaj +1 more source