Results 191 to 200 of about 23,457 (205)

Rab7 induces clearance of α‐synuclein aggregates

Journal of Neurochemistry, 2016
AbstractParkinson's disease can be caused by mutations in the α‐synuclein gene and is characterized by aggregates of α‐synuclein protein. Aggregates are degraded by the autophago‐lysosomal pathway. Since Rab7 has been shown to regulate trafficking of late endosomes and autophagosomes, we hypothesized that over‐expressing Rab7 might be beneficial in ...
Elisabeth Dinter, Theodora Saridaki, Markus Nippold, Sarah Plum, Leonie Diederichs, Daniel Komnig, Luisa Fensky, Caroline May, Katrin Marcus, Aaron Voigt, Jörg B. Schulz, Björn H. Falkenburger   +11 more
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Tyrosine phosphorylation of Rab7 by Src kinase

Cellular Signalling, 2017
The small molecular weight GTPase Rab7 is a key regulator for late endosomal/lysosomal membrane trafficking, it was known that Rab7 is phosphorylated, but the corresponding kinase and the functional regulation of Rab7 phosphorylation remain unclear. We provide evidence here that Rab7 is a substrate of Src kinase, and is tyrosine-phosphorylated by Src ...
Xiaosi, Lin, Jiaming, Zhang, Lingqiu, Chen, Yongjun, Chen, Xiaohui, Xu, Wanjin, Hong, Tuanlao, Wang   +6 more
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Rab7 regulates phagosome maturation in Dictyostelium

Journal of Cell Science, 2001
A Dictyostelium Rab7 homolog has been demonstrated to regulate fluid-phase influx, efflux, retention of lysosomal hydrolases and phagocytosis. Since Rab7 function appeared to be required for efficient phagocytosis, we sought to further characterize the role of Rab7 in phagosomal maturation.
A, Rupper, B, Grove, J, Cardelli
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CMT2B-associated Rab7 mutants inhibit neurite outgrowth

Acta Neuropathologica, 2010
Charco-Marie-Tooth type 2B (CMT2B) neuropathy is a rare autosomal-dominant axonal disorder characterized by distal weakness, muscle atrophy, and prominent sensory loss often complicated by foot ulcerations. CMT2B is associated with mutations of the Rab7 protein, a small GTPase controlling late endocytic traffic. Currently, it is still unknown how these
Cogli L, Progida C, Lecci R, Bramato R, Krüttgen A, BUCCI, Cecilia   +5 more
openaire   +3 more sources

Rab7 controls lipid droplet-phagosome association during mycobacterial infection

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2020
Lipid droplets (LDs) are organelles that have multiple roles in inflammatory and infectious diseases. LD act as essential platforms for immunometabolic regulation, including as sites for lipid storage and metabolism, inflammatory lipid mediator production, and signaling pathway compartmentalization.
Natalia R, Roque, Silvia L, Lage, Roberta, Navarro, Narayana, Fazolini, Clarissa M, Maya-Monteiro, Jens, Rietdorf, Rossana C N, Melo, Heloisa, D'Avila, Patricia T, Bozza   +8 more
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Dissection of Rab7 localization on Mycobacterium tuberculosis phagosome

Biochemical and Biophysical Research Communications, 2009
The late endosomal marker Rab7 has been long believed to be absent from the phagosome containing Mycobacterium tuberculosis (M.tb) in macrophage, but the detail kinetics remains elusive. Here, we found that Rab7 is transiently recruited to and subsequently released from M.tb phagosomes.
Shintaro, Seto, Sohkichi, Matsumoto, Isamu, Ohta, Kunio, Tsujimura, Yukio, Koide   +4 more
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Intein-Mediated Synthesis of Geranylgeranylated Rab7 Protein in Vitro

Journal of the American Chemical Society, 2002
Production of recombinant proteins is an important prerequisite for biotechnology and life sciences in general. However, there is a paucity of methods for production of posttranslationally modified recombinant proteins or proteins with non-native functional groups, such as fluorophores, spin labels, and so forth. In this work we have used a combination
Alexandrov, K., Heinemann, I., Durek, T., Sidorovitch, V., Goody, R. S., Waldmann, H.   +5 more
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Human VPS34 and p150 are Rab7 Interacting Partners

Traffic, 2003
Regulation of membrane trafficking requires the concerted actions of rab proteins, their effectors and several phosphatidylinositol 3′‐kinases. Rab7 is required for late endosomal transport and here we establish that the phosphatidylinositol 3′‐kinase hVPS34 and its adaptor protein p150 are rab7 interacting partners. The hVPS34/p150 complex colocalized
Mary-Pat, Stein, Yan, Feng, Karen L, Cooper, Angela M, Welford, Angela, Wandinger-Ness   +4 more
openaire   +2 more sources

Trypanosoma cruzi: Cloning and Characterization of a RAB7 gene

Experimental Parasitology, 2000
The small monomeric GTP-binding proteins of the RAB subfamily are key regulatory elements of the machinery that controls membrane traffic in eukaryotic cells. These proteins have been localized to many different intracellular organelles, on both endocytic and exocytic compartments, suggesting that each step of vesicular traffic can involve a specific ...
S T, Leal, J R, Araripe, T P, Urményi, G A, Cross, E, Rondinelli   +4 more
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Cloning and expression analysis of the murine Rab7 cDNA

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1995
A cDNA clone coding for the Rab7 protein was isolated from an NIH3T3 cell line (mouse fibroblasts) cDNA library. Sequence analysis shows high homology to the rat and dog cDNAs. Northern blot analysis showed the presence of two messenger RNA that differ at the 3' untranslated region.
VITELLI R, CHIARIELLO M, BRUNI CB, BUCCI, Cecilia   +3 more
openaire   +5 more sources