Role for Rab7 in maturation of late autophagic vacuoles [PDF]
Journal of Cell Science, 2004 The small GTP binding protein Rab7 has a role in the late endocytic pathway and lysosome biogenesis. The role of mammalian Rab7 in autophagy is, however, unknown. We have addressed this by inhibiting Rab7 function with RNA interference and overexpression of dominant negative Rab7.
JAGER S. +6 more
openaire +4 more sources
Mechanistic and Functional Studies of Rab7 Phosphorylation [PDF]
, 2016 Rab7调控着从内体到溶酶体以及从内体到高尔基体的囊泡运输过程；也参与了自噬、吞噬过程；同时还调节着溶酶体及其相关细胞器的生成过程。Rab7的功能受到各种相互作用因子的调控；Rab7的功能异常会导致包括神经退行性疾病和肿瘤在内的多种疾病。前期实验发现Rab7与Src在早期内体和晚期内体共定位，另有报道v-Src可激活Rab7，但是Src对Rab7的调节机制尚不清楚。 本研究发现Src、Blk等酪氨酸激酶可磷酸化修饰Rab7，其磷酸化位点为第183位酪氨酸残基 ...
林晓思
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Defective phagocytic corpse processing results in neurodegeneration and can be rescued by TORC1 activation [PDF]
, 2016 This work was supported by NIH Grants R01 GM094452 (K.M.) and F31 GM099425 (J.I.E.), BU Alzheimer's Disease Core Center NIH Grant P30 AG13846, Boston University Undergraduate Research Opportunities Program grants (J.A.T., V.S.), and NIH Grant R01 ...
Elguero, Emma J. +5 more
core +1 more source
Advanced Science, EarlyView.This study identifies platelet‐derived extracellular vesicles as key immunometabolic regulators in COVID‐19. The delivery of tRF‐His‐GTG‐1 to neutrophils activates TLR8mTOR signaling, disrupts lipophagy, and amplifies NET‐mediated inflammation. Importantly, targeting this axis restores neutrophil homeostasis, offering a potential therapeutic strategy ...
Tsai‐Ling Liao +5 more
wiley +1 more source
Lysosome-associated miniSOG as a photosensitizer for mammalian cells
BioTechniques, 2016 Genetically encoded photosensitizers represent a promising optogenetic tool for the induction of light-controlled oxidative stress strictly localized to a selected intracellular compartment.
Alina P. Ryumina +6 more
doaj +1 more source
Differences in endosomal Rab gene expression between positive and negative COVID-19 patients
BMC Research Notes, 2022 Objective SARS CoV-2, the etiologic agent of coronavirus disease-2019 (COVID-19) is well-known to use ACE2 to begin internalization. Some viruses enter the host cell through the endocytosis process and involve some endocytosis proteins, such as the Rab ...
Nur Atik +4 more
doaj +1 more source
CRISPR-Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptide-repeat-protein toxicity. [PDF]
, 2018 Hexanucleotide-repeat expansions in the C9ORF72 gene are the most common cause of amyotrophic lateral sclerosis and frontotemporal dementia (c9ALS/FTD).
A Berson +95 more
core +1 more source
Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53
Advanced Science, EarlyView.NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore +20 more
wiley +1 more source
Adenovirus RIDα regulates endosome maturation by mimicking GTP-Rab7 [PDF]
The Journal of Cell Biology, 2007 The small guanosine triphosphatase Rab7 regulates late endocytic trafficking. Rab7-interacting lysosomal protein (RILP) and oxysterol-binding protein–related protein 1L (ORP1L) are guanosine triphosphate (GTP)–Rab7 effectors that instigate minus end–directed microtubule transport.
Shah, Ankur H. +4 more
openaire +2 more sources
Mon1-Ccz1 activates Rab7 only on late endosomes and dissociates from the lysosome in mammalian cells [PDF]
, 2016 Rab GTPases act as molecular switches regulating various aspects of membrane trafficking. Among them, Rab5 and Rab7 play central roles in the endolysosomal network.
Fujita, A +8 more
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