RAC1 promotes the occurrence and development of tongue squamous cell carcinoma by regulating RAC1/PAK1/LIMK1 signaling pathway [PDF]
Scientific ReportsTongue squamous cell carcinoma (TSCC) remains an unsolved medical problem due to its poor local recurrence rate and prognosis. The purpose of this study was to investigate the expression characteristics of RAC-related C3 botulinum toxin substrate 1(RAC1)
Zongxuan He +5 more
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Circulating RAC1 contributed to steroid-sensitive nephrotic syndrome: Mendelian randomization, single-cell RNA-sequencing, proteomic, and experimental evidence [PDF]
Renal FailureObjectives The small GTPase Rac1 (RAC1) has been linked to podocyte disorders and steroid-sensitive nephrotic syndrome (SSNS). The aim of this study was to explore and validate the potential causal association between circulating RAC1 and SSNS.Methods ...
Yi Zhang +4 more
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Melittin Prevents Metastasis of Epidermal Growth Factor-Induced MDA-MB-231 Cells through The Inhibition of The SDF-1α/CXCR4 Signaling Pathway [PDF]
Cell Journal, 2022 Objective: Melittin is one of the natural components of bee venom (Apis mellifera), and its anticancer and antimetastatic properties have been well established, but the underlying mechanism remains elusive.
Fatemeh Salimian +2 more
doaj +1 more source
Roads to Stat3 Paved with Cadherins
Cells, 2022 The engagement of cadherins, cell-to-cell adhesion proteins, triggers a dramatic increase in the levels and activity of the Rac/Cdc42 GTPases, through the inhibition of proteasomal degradation.
Hanad Adan, Juliet Daniel, Leda Raptis
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Short-hairpin RNA-mediated suppression of cortactin may inhibit the migration and invasion abilities of endometrial cancer cells by reducing lamellipodia [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): The prognosis of endometrial cancer (EC) is significantly affected by tumor infiltration and metastasis. Cortactin (CTTN) regulates infiltration and metastasis in other tumors. Studies on the role and mechanism of CTTN in EC are limited and
Huisi Lin +4 more
doaj +1 more source
PLoS ONE, 2021 Signaling by the Rho GTPase Rac1 is key to the regulation of cytoskeletal dynamics, cell spreading and adhesion. It is widely accepted that the inactive form of Rac1 is bound by Rho GDI, which prevents Rac1 activation and Rac1-effector interactions.
Jisca Majolée +3 more
doaj +1 more source
Presynaptic Rac1 controls synaptic strength through the regulation of synaptic vesicle priming
eLife, 2022 Synapses contain a limited number of synaptic vesicles (SVs) that are released in response to action potentials (APs). Therefore, sustaining synaptic transmission over a wide range of AP firing rates and timescales depends on SV release and replenishment.
Christian Keine +9 more
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The preventive effect of atorvastatin on liver fibrosis in the bile duct ligation rats via antioxidant activity and down-regulation of Rac1 and NOX1 [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Objective(s): Atorvastatin is a cholesterol-lowering agent capable of inhibiting 3-hydroxy-3-methylglutaryl coenzyme A reductase. Recent studies have demonstrated new facets of atorvastatin, such as antioxidant and anti-fibrotic properties.
Zohreh-al-sadat Ghoreshi +4 more
doaj +1 more source
Lysine Acetylation Reshapes the Downstream Signaling Landscape of Vav1 in Lymphocytes
Cells, 2020 Vav1 works both as a catalytic Rho GTPase activator and an adaptor molecule. These functions, which are critical for T cell development and antigenic responses, are tyrosine phosphorylation-dependent.
Sonia Rodríguez-Fdez +3 more
doaj +1 more source
FilGAP, a GAP for Rac1, down-regulates invadopodia formation in breast cancer cells
Cell Structure and Function, 2023 Invadopodia are protrusive structures that mediate the extracellular matrix (ECM) degradation required for tumor invasion and metastasis. Rho small GTPases regulate invadopodia formation, but the molecular mechanisms of how Rho small GTPase activities ...
Koji Saito +8 more
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