Results 1 to 10 of about 131,005 (322)

Gradients of Rac1 Nanoclusters Support Spatial Patterns of Rac1 Signaling [PDF]

Cell Reports, 2017
Summary: Rac1 is a small RhoGTPase switch that orchestrates actin branching in space and time and protrusion/retraction cycles of the lamellipodia at the cell front during mesenchymal migration.
Amanda Remorino, Simon De Beco, Fanny Cayrac, Fahima Di Federico, Gaetan Cornilleau, Alexis Gautreau, Maria Carla Parrini, Jean-Baptiste Masson, Maxime Dahan, Mathieu Coppey   +9 more
doaj   +7 more sources

The Small GTPase Rac1 Increases Cell Surface Stiffness and Enhances 3D Migration Into Extracellular Matrices

Scientific Reports, 2019
Membrane ruffling and lamellipodia formation promote the motility of adherent cells in two-dimensional motility assays by mechano-sensing of the microenvironment and initiation of focal adhesions towards their surroundings.
Tom Kunschmann, Stefanie Puder, Tony Fischer, Anika Steffen, Klemens Rottner, Claudia Tanja Mierke   +5 more
doaj   +2 more sources

Suppression of RAC1-driven malignant melanoma by group A PAK inhibitors

Oncogene, 2017
Activating mutations in the RAC1 gene have recently been discovered as driver events in malignant melanoma. Expression of this gene is associated with melanocyte proliferation, and melanoma cells bearing this mutation are insensitive to BRAF inhibitors ...
Daniela Araiza‐Olivera, Yayi Feng, Galina Semenova, Tatiana Y. Prudnikova, Jennifer Rhodes, Jonathan Chernoff   +5 more
openalex   +2 more sources

Coxiella burnetii Phagocytosis Is Regulated by GTPases of the Rho Family and the RhoA Effectors mDia1 and ROCK [PDF]

, 2015
The GTPases belonging to the Rho family control the actin cytoskeleton rearrangements needed for particle internalization during phagocytosis. ROCK and mDia1 are downstream effectors of RhoA, a GTPase involved in that process.
A Alonso, A Schonichen, A Subtil, A Tierrez, A Yoneda, AB Hall, AB Jaffe, AD Hoppe, AL Bishop, AP Wheeler, AR Frampton Jr., AS Alberts, B Qualmann, BJ Wallar, C Capo, C Cougoule, C Yang, CA Burnham, CM Haglund, CW Gourlay, D Howe, D Michaelson, D Michaelson, D Truong, Daniel E. Voth, DE Voth, DJ Hackam, DM Underhill, DM Waag, DT Brandt, E Alix, E Caron, E Colucci-Guyon, E Lemichez, EJ van Schaik, EM Rosales, EN Firat-Karalar, F Li, F Matsumura, F Niedergang, G Kaplan, GD Fairn, H Bierne, H Bierne, H Genth, HJ Newton, IM Olazabal, J Dellacasagrande, J Faix, J Hanisch, J Pizarro-Cerda, J Pizarro-Cerda, JA McDonough, JA Swanson, JC Patel, JC Patel, JE Heindl, Jesús S. Distel, JG Duman, JG Kim, K Aktories, K Bhadriraju, L Hodgson, LA Allen, M Aguilera, M Amano, M Amano, M Fernandez-Borja, M Kaksonen, M Ladwein, María I. Colombo, MG Gutierrez, Milton O. Aguilera, ML Gardel, N Ramalingam, N Watanabe, N Watanabe, NA Khan, O Billker, O Pertz, O Pertz, OB Matas, OG Baca, OG Baca, P Aspenstrom, P Cossart, P Croise, P Hotulainen, PJ Roberts, PS Romano, R Fox, RA Carabeo, RC May, RC May, Rodolfo M. Ortiz Flores, Romina P. Salinas, RS Flannagan, S Meconi, SJ Heasman, SK Hussain, T Dubois, T Tominaga, V Benard, VC Tam, W Beron, Walter Berón, WI Goh, X Chi, XD Ren, Z Woldehiwet   +109 more
core   +25 more sources

Three-dimensional biomimetic vascular model reveals a RhoA, Rac1, and N -cadherin balance in mural cell–endothelial cell-regulated barrier function [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2017
Stella Alimperti, Teodelinda Mirabella, Varnica Bajaj, William J. Polacheck, Dana M. Pirone, Jeremy S. Duffield, Jeroen Eyckmans, Richard K. Assoian, Christopher S. Chen   +8 more
openalex   +2 more sources

Rac1: A Regulator of Cell Migration and a Potential Target for Cancer Therapy

Molecules, 2023
Cell migration is crucial for physiological and pathological processes such as morphogenesis, wound repair, immune response and cancer invasion/metastasis. There are many factors affecting cell migration, and the regulatory mechanisms are complex.
Ning Ma, Erqian Xu, Qing Luo, Guanbin Song   +3 more
semanticscholar   +1 more source

Rhein Inhibited Ferroptosis and EMT to Attenuate Diabetic Nephropathy by Regulating the Rac1/NOX1/β-Catenin Axis.

Frontiers in Bioscience, 2023
BACKGROUND Diabetic nephropathy (DN) is one of the most serious complications of diabetes. Rhein has been reported to be effective in treating DN. This study aimed to investigate the role and mechanism of rhein in the treatment of DN.
Dan Xiong, Wei Hu, Xiaofang Han, Yahong Cai   +3 more
semanticscholar   +1 more source

Roads to Stat3 Paved with Cadherins

Cells, 2022
The engagement of cadherins, cell-to-cell adhesion proteins, triggers a dramatic increase in the levels and activity of the Rac/Cdc42 GTPases, through the inhibition of proteasomal degradation.
Hanad Adan, Juliet Daniel, Leda Raptis
doaj   +1 more source

Structures reveal a key mechanism of WAVE regulatory complex activation by Rac1 GTPase

bioRxiv, 2022
Rho-family GTPase Rac1 activates the WAVE regulatory complex (WRC) to drive Arp2/3-mediated actin polymerization in many essential processes. Rac1 binds to WRC at two distinct sites—the A and D sites. Precisely how Rac1 binds and how the binding triggers
Bojian Ding, Sheng Yang, M. Schaks, Yijun Liu, Abbigale J. Brown, K. Rottner, S. Chowdhury, Baoyu Chen   +7 more
semanticscholar   +1 more source

Presynaptic Rac1 controls synaptic strength through the regulation of synaptic vesicle priming

eLife, 2022
Synapses contain a limited number of synaptic vesicles (SVs) that are released in response to action potentials (APs). Therefore, sustaining synaptic transmission over a wide range of AP firing rates and timescales depends on SV release and replenishment.
Christian Keine, Mohammed Al-Yaari, Tamara Radulovic, Connon I Thomas, Paula Valino Ramos, Debbie Guerrero-Given, Mrinalini Ranjan, Holger Taschenberger, Naomi Kamasawa, Samuel M Young Jr   +9 more
doaj   +1 more source