Results 91 to 100 of about 73,055 (186)

The Tail Domain of Myosin M Catalyses Nucleotide Exchange on Rac1 GTPases and Can Induce Actin‐Driven Surface Protrusions [PDF]

, 2000
Heidrun Geissler, Ronald Ullmann, Thierry Soldati   +2 more
openalex   +1 more source

ROS‐Driven PKCζ Signaling as a Widely Involved Mechanism for Cancer Cell Motility and Metastasis

Cancer Science, Volume 116, Issue 11, Page 3027-3039, November 2025.
This study reveals that the enhancement of cancer cell motility by diverse bioactive molecules—including growth factors, hormones, and tissue factors—is mediated through a common intracellular mechanism involving reactive oxygen species (ROS) and the PKCζ/Rho GTPase signaling pathway.
Yasushi Sato, Maki Tanaka, Naoko Kitamura, Naoko Araki, Wataru Kurata, Akiko Sasaki, Yukimi Seo, Kageaki Kuribayashi, Shuzo Kobayashi, Yoshiro Niitsu   +9 more
wiley   +1 more source

Circulating RAC1 contributed to steroid-sensitive nephrotic syndrome: Mendelian randomization, single-cell RNA-sequencing, proteomic, and experimental evidence

Renal Failure
Objectives The small GTPase Rac1 (RAC1) has been linked to podocyte disorders and steroid-sensitive nephrotic syndrome (SSNS). The aim of this study was to explore and validate the potential causal association between circulating RAC1 and SSNS.Methods ...
Yi Zhang, Tianwen Yao, Yanqiu Xu, Yi Wang, Shisheng Han   +4 more
doaj   +1 more source

Case Report: Association of Ocular Colobomas With a Novel Missense Variant in CDC42, a Member of the Rho Family of Small GTPases

Clinical Genetics, Volume 108, Issue 5, Page 589-593, November 2025.
We report a 2‐year‐old male with clinical features of Takenouchi‐Kosaki syndrome, bilateral colobomas, and a de novo, likely pathogenic missense variant in CDC42. Supportive evidence includes a Cdc42 conditional knock‐out mouse model with colobomas.
Diana Brightman, Nawaal Shinwari, Aleksey Porollo, Eniolami O. Dosunmu, Ehsan Ullah, Bin Guan, Robert B. Hufnagel, Brian P. Brooks, Delphine Blain, Sabine Fuhrmann, Brittany Simpson, Anne M. Slavotinek   +11 more
wiley   +1 more source

Regulation of Somatodendritic GABA_A Receptor Channels in Rat Hippocampal Neurons: Evidence for a Role of the Small GTPase Rac1 [PDF]

, 2000
Dieter Meyer, Claudia Olenik, Fred Hofmann, Holger Barth, Jost Leemhuis, Ina Brünig, Klaus Aktories, Wolfgang Nörenberg   +7 more
openalex   +1 more source

Participation of the small molecular weight GTP-binding protein Rac1 in cell-free activation and assembly of the respiratory burst oxidase. Inhibition by a carboxyl-terminal Rac peptide.

, 1994
Mary L. Kreck, David J. Uhlinger, S.R. Tyagi, K. Leigh Inge, J. David Lambeth   +4 more
openalex   +1 more source

Altered focal adhesion regulation correlates with cardiomyopathy in mice expressing constitutively active rac1 [PDF]

, 2000
Mark A. Sussman, Sara Welch, Angela Walker, Raisa Klevitsky, Timothy E. Hewett, Robert L. Price, Erik Schaefer, Karen L. Yager   +7 more
openalex   +1 more source

rac1 Regulates a Cytokine-Stimulated, Redox-Dependent Pathway Necessary for NF-κB Activation

, 1996
David J. Sulciner, Kaikobad Irani, Zu‐Xi Yu, Victor J. Ferrans, Pascal J. Goldschmidt–Clermont, Toren Finkel   +5 more
openalex   +2 more sources

Nerve Growth Factor-induced Neuronal Differentiation Requires Generation of Rac1-regulated Reactive Oxygen Species [PDF]

, 2000
Kazumi Suzukawa, Koichi Miura, Junji Mitsushita, James Resau, Kunitaka Hirose, Ronald G. Crystal, Tohru Kamata   +6 more
openalex   +1 more source

Vav2 Is an Activator of Cdc42, Rac1, and RhoA [PDF]

, 2000
Karon Abe, Kent L. Rossman, Betty Liu, Kimberly Ritola, Derek Y. Chiang, Sharon L. Campbell, Keith Burridge, Channing J. Der   +7 more
openalex   +1 more source