Results 101 to 110 of about 131,005 (322)

ELMO1 has an essential role in the internalization of Salmonella Typhimurium into enteric macrophages that impacts disease outcome. [PDF]

, 2015
Backgrounds and aims4-6 million people die of enteric infections each year. After invading intestinal epithelial cells, enteric bacteria encounter phagocytes.
Casanova, James E, Castillo, Victoria, Choudhury, Sarmistha Sinha, Das, Soumita, Eckmann, Lars, Elliott, Michael R, Ernst, Peter B, Fox, Sarah, Owen, Katherine A, Sarkar, Arup   +9 more
core  

Coronin-1C and RCC2 guide mesenchymal migration by trafficking Rac1 and controlling GEF exposure [PDF]

, 2014
Sustained forward migration through a fibrillar extracellular matrix requires localization of protrusive signals. Contact with fibronectin at the tip of a cell protrusion activates Rac1, and for linear migration it is necessary to dampen Rac1 activity in
Bass, Burridge, Bünger, Castro-Castro, Chan, Comeau, Cui, Danen, del Pozo, DeLano, Hammond, Humphries, Itoh, Lambert, Lawson, Liu, Machacek, Matthews, Mollinari, Neilson, Nethe, Nomanbhoy, Renault, Sharma, Swaminathan, Tarricone, van Rijssel, Wada, Walker, Wang, Wu, Xavier   +31 more
core   +1 more source

Optogenetic dissection of Rac1 and Cdc42 gradient shaping

Nature Communications, 2018
During cell migration, Rho GTPases spontaneously form spatial gradients that define the front and back of cells. At the front, active Cdc42 forms a steep gradient whereas active Rac1 forms a more extended pattern peaking a few microns away.
Simon de Beco, Kotryna Vaidžiulytė, J. Manzi, F. Dalier, Fahima Di Frederico, Gaétan Cornilleau, Maxime Dahan, M. Coppey   +7 more
semanticscholar   +1 more source

Development of Endogenous Protein Probes for Characterizing Surface Proteins and Cellular Interactors of Extracellular Vesicles

Advanced Science, EarlyView.
The proximity labeling enzyme APEX2 is displayed on extracellular vesicle (EV) surfaces via genetic fusion with EV‐sorting scaffolds, enabling in situ biotinylation of native surface proteins, adsorbed corona components, and interacting cellular proteins.
Wenyi Zheng, Metoboroghene Mowoe, Wenqing Hou, Daniel W. Hagey, Koshi Imami, Samir EL Andaloussi   +5 more
wiley   +1 more source

Investigating the role of ras-related c3 botulinum toxin substrate 1(rac1) in modulating tumor necrosis factor alpha (tnf-α) mediated inflammation in a streptozotocin-induced mouse model of Alzheimer's disease

Zanco Journal of Medical Sciences
Background and objective: Alzheimer's disease (AD) is a slowly worsening brain disease linked to ongoing inflammation, with Tumor Necrosis Factor Alpha (TNF-α) playing a significant function in its progression.
Rundk Hwaiz
doaj   +1 more source

Platelet Rho GTPase regulation in physiology and disease

Platelets, 2019
Rho GTPases are master orchestrators of cytoskeletal dynamics and serve critical roles in platelet physiology to promote hemostasis or pathology in thrombotic, inflammatory and other disease states.
Joseph E. Aslan
doaj   +1 more source

Anosmin-1 modulates fibroblast growth factor receptor 1 signaling in human gonadotropin-releasing hormone olfactory neuroblasts through a heparan sulfate-dependent mechanism [PDF]

, 2004
Defects of either anosmin-1 or fibroblast growth factor receptor 1 (FGFR1) are known to underlie hereditary Kallmann's syndrome (KS), a human disorder of olfactory and gonadotropin-releasing hormone (GnRH) neuronal ontogeny.
Bouloux, PM, Gonzalez-Martinez, D, Guimond, S, Hu, YL, Kim, SH, Schofield, J, Turnbull, J, Vannelli, GB, Winyard, P   +8 more
core   +1 more source

Parallel Genome‐Wide CRISPR Screens Reveal SORL1 and ZFYVE19 as Sequential Host Determinants of Salmonella Infection

Advanced Science, EarlyView.
To distinguish how Salmonella invades cells vs how it survives long‐term, a parallel CRISPR screening platform is developed. This approach reveals the host proteins that the bacterium exploits at different stages of infection. The study identifies SORL1 as a novel host factor for invasion and demonstrates that blocking it with an antibody effectively ...
Sehee Yun, Seoyeon Kim, Seonggyu Kim, Minsoo Noh, Dae‐Kyum Kim, Eun‐Jin Lee, Hunsang Lee   +6 more
wiley   +1 more source

Rho GTPases and their downstream effectors in megakaryocyte biology

Platelets, 2019
Megakaryocytes differentiate from hematopoietic stem cells in the bone marrow. The transition of megakaryocytes to platelets is a complex process. Thereby, megakaryocytes extend proplatelets into sinusoidal blood vessels, where the proplatelets undergo ...
Irina Pleines, Deya Cherpokova, Markus Bender   +2 more
doaj   +1 more source

Deletion of Rac1GTPase in the Myeloid Lineage Protects against Inflammation-Mediated Kidney Injury in Mice.

PLoS ONE, 2016
Macrophage-mediated inflammation has been implicated in various kidney diseases. We previously reported that Rac1, a Rho family small GTP-binding protein, was overactivated in several chronic kidney disease models, and that Rac1 inhibitors ameliorated ...
Miki Nagase, Hidetake Kurihara, Atsu Aiba, Morag J Young, Tatsuo Sakai   +4 more
doaj   +1 more source