Results 21 to 30 of about 131,005 (322)

Mechanistic Differences of Activation of Rac1^P29S and Rac1^A159V [PDF]

The Journal of Physical Chemistry B, 2021
Rac1 is a small GTPase that plays key roles in actin reorganization, cell motility, and cell survival/growth as well as in various cancer types and neurodegenerative diseases. Similar to other Ras superfamily GTPases, Rac1 switches between active GTP-bound and inactive GDP-bound states.
Simge Senyuz, Hyunbum Jang, Ruth Nussinov, Ozlem Keskin, Attila Gursoy   +4 more
openaire   +4 more sources

Regulation of local GTP availability controls RAC1 activity and cell invasion

Nature Communications, 2021
Physiological changes in GTP levels in live cells have never been considered a regulatory step of RAC1 activation because intracellular GTP concentration (determined by chromatography or mass spectrometry) was shown to be substantially higher than the in
A. Bianchi-Smiraglia, D. Wolff, Daniel J. Marston, Zhiyong Deng, Zhannan Han, S. Moparthy, Rebecca M Wombacher, Ashley Mussell, S. Shen, Jialin Chen, D. Yun, Anderson O'Brien Cox, C. Furdui, E. Hurley, M. Feltri, J. Qu, T. Hollis, Jules Berlin Nde Kengne, Bernard Fongang, R. Sousa, M. Kandel, E. Kandel, K. Hahn, M. Nikiforov   +23 more
semanticscholar   +1 more source

Rac1 activates non-oxidative pentose phosphate pathway to induce chemoresistance of breast cancer

Nature Communications, 2020
Resistance development to one chemotherapeutic reagent leads frequently to acquired tolerance to other compounds, limiting the therapeutic options for cancer treatment.
Qingjian Li, T. Qin, Z. Bi, H. Hong, L. Ding, Jiewen Chen, Wei Wu, Xiaorong Lin, Wenkui Fu, Fang Zheng, Yandan Yao, Manli Luo, P. Saw, G. Wulf, Xiaoding Xu, E. Song, H. Yao, Hai Hu   +17 more
semanticscholar   +1 more source

The preventive effect of atorvastatin on liver fibrosis in the bile duct ligation rats via antioxidant activity and down-regulation of Rac1 and NOX1 [PDF]

Iranian Journal of Basic Medical Sciences, 2020
Objective(s): Atorvastatin is a cholesterol-lowering agent capable of inhibiting 3-hydroxy-3-methylglutaryl coenzyme A reductase. Recent studies have demonstrated new facets of atorvastatin, such as antioxidant and anti-fibrotic properties.
Zohreh-al-sadat Ghoreshi, Razieh Kabirifar, Ameneh Khodarahmi, Alireza karimollah, Ali Moradi   +4 more
doaj   +1 more source

Granule Cell Dispersion in Human Temporal Lobe Epilepsy: Proteomics investigation of neurodevelopmental migratory pathways [PDF]

, 2020
Granule cell dispersion (GCD) is a common pathological feature observed in the hippocampus of patients with Mesial Temporal Lobe Epilepsy (MTLE). Pathomechanisms underlying GCD remain to be elucidated, but one hypothesis proposes aberrant reactivation of
Al-Kaaby, B., Al-Kaaby, B., Dzurova, N., Dzurova, N., Liu, J., Liu, J., Millks, K., Millks, K., Sisodiya, S.M., Sisodiya, S.M., Thom, M., Thom, M.   +11 more
core   +1 more source

Rac1 regulates pancreatic islet morphogenesis [PDF]

BMC Developmental Biology, 2009
Abstract Background Pancreatic islets of Langerhans originate from endocrine progenitors within the pancreatic ductal epithelium. Concomitant with differentiation of these progenitors into hormone-producing cells such cells delaminate, aggregate and migrate away from the ductal epithelium.
Greiner, Thomas, Kesavan, Gokul, Ståhlberg, Anders, Semb, Henrik   +3 more
openaire   +4 more sources

RAC1/miR-3613/RAC1 feedback loop contributes to ovarian cancer progression [PDF]

, 2021
Abstract The RAC1 signal pathway is involved in various tumor cell biological processes. Here, the role of RAC1-miR-3613-RAC1 negative feedback loop in ovarian cancer was explored. Results showed that RAC1 knockdown up-regulated miR-3613, which in turn inhibited RAC1 expression.
Changzhong Li, Ruobing Leng, Yunfang Meng, Na Li, Feifei Li, Yingzi Zhao   +5 more
openaire   +1 more source

Modulation of the Pol II CTD Phosphorylation Code by Rac1 and Cdc42 Small GTPases in Cultured Human Cancer Cells and Its Implication for Developing a Synthetic-Lethal Cancer Therapy

Cells, 2020
Rho GTPases, including Rho, Cdc42, Rac and ROP subfamilies, are key signaling molecules in RNA polymerase II (Pol II) transcriptional control.
Bo Zhang, Xuelin Zhong, Moira Sauane, Yihong Zhao, Zhi-Liang Zheng   +4 more
doaj   +1 more source

The E3 ubiquitin ligase MG53 inhibits hepatocellular carcinoma by targeting RAC1 signaling

Oncogenesis, 2022
Ras-related C3 botulinum toxin substrate 1 (RAC1) overexpressiosn and hyperactivation are correlated with aggressive growth and other malignant characteristics in a wide variety of cancers including hepatocellular carcinoma (HCC). However, the regulatory
Xiaomin Ma, Xiaoxiao Ma, Lihui Zhu, Yunxue Zhao, Mengmeng Chen, Tao Li, Yueke Lin, Dapeng Ma, Caiyu Sun, Lihui Han   +9 more
doaj   +1 more source

The formin FHOD1 and the small GTPase Rac1 promote vaccinia virus actin-based motility [PDF]

, 2013
Vaccinia virus dissemination relies on the N-WASP– ARP2/3 pathway, which mediates actin tail formation underneath cell-associated extracellular viruses (CEVs).
Alberts, Alvarez, Arakawa, Bagrodia, Bernardini, Block, Boujemaa-Paterski, Chong, Chong, Diego E. Alvarez, Earl, Engelstad, Feig, Frischknecht, Fukuoka, Gasteier, Goldberg, Haglund, Hannemann, Harris, Harris, Heindl, Hervé Agaisse, Hiller, Hollinshead, Hoppe, Humphries, Isaacs, Katz, Kleba, Koka, Kovar, Krall, Lammers, Lasa, Li, Madrid, Moseley, Moseley, Newsome, Newsome, Nezami, Otomo, Parkinson, Pollard, Pring, Pruyne, Qiu, Ridley, Rietdorf, Roberts, Rolls, Romero, Röttger, Sanderson, Scaplehorn, Schmelz, Schulte, Schönichen, Schönichen, Serio, Shibata, Siripala, Skoble, Smith, Suzuki, Takeya, Tooze, van Eijl, van Eijl, Wallar, Ward, Ward, Watanabe, Weisswange, Welch, Westendorf, Westendorf, Wolffe, Wolffe   +79 more
core   +2 more sources