Results 21 to 30 of about 73,055 (186)

Genetic alterations and markers of melanoma

Успехи молекулярной онкологии, 2015
Melanoma remains the most deadly form of malignant skin disease with high risk of metastases. Metastatic melanoma is prognostic highly unfavorable and resistant to traditional chemotherapy and biologic treatment.
N. N. Mazurenko
doaj   +1 more source

Characterization and functional analysis of the calmodulin-binding domain of Rac1 GTPase. [PDF]

PLoS ONE, 2012
Rac1, a member of the Rho family of small GTPases, has been shown to promote formation of lamellipodia at the leading edge of motile cells and affect cell migration.
Bing Xu, Prashen Chelikani, Rajinder P Bhullar   +2 more
doaj   +1 more source

Cocaine activates Rac1 to control structural and behavioral plasticity in caudate putamen

Neurobiology of Disease, 2015
Repeated exposure to cocaine was previously found to cause sensitized behavioral responses and structural remodeling on medium spiny neurons of the nucleus accumbens (NAc) and caudate putamen (CPu).
Juan Li, Lei Zhang, Zhenzhong Chen, Minjuan Xie, Lu Huang, Jinhua Xue, Yutong Liu, Nuyun Liu, Fukun Guo, Yi Zheng, Jiming Kong, Lin Zhang, Lu Zhang   +12 more
doaj   +1 more source

Lack of RAC1 in macrophages protects against atherosclerosis.

PLoS ONE, 2020
The Rho GTPase RAC1 is an important regulator of cytoskeletal dynamics, but the role of macrophage-specific RAC1 has not been explored during atherogenesis. We analyzed RAC1 expression in human carotid atherosclerotic plaques using immunofluorescence and
Sashidar Bandaru, Chandu Ala, Matias Ekstrand, Murali K Akula, Matteo Pedrelli, Xi Liu, Göran Bergström, Liliana Håversen, Jan Borén, Martin O Bergo, Levent M Akyürek   +10 more
doaj   +2 more sources

Serine-71 phosphorylation of Rac1 modulates downstream signaling. [PDF]

PLoS ONE, 2012
The Rho GTPases Rac1 and Cdc42 regulate a variety of cellular functions by signaling to different signal pathways. It is believed that the presence of a specific effector at the location of GTPase activation determines the route of downstream signaling ...
Janett Schwarz, Julia Proff, Anika Hävemeier, Markus Ladwein, Klemens Rottner, Britta Barlag, Andreas Pich, Helma Tatge, Ingo Just, Ralf Gerhard   +9 more
doaj   +1 more source

Yersinia pseudotuberculosis Spatially Controls Activation and Misregulation of Host Cell Rac1. [PDF]

PLoS Pathogens, 2005
Yersinia pseudotuberculosis binds host cells and modulates the mammalian Rac1 guanosine triphosphatase (GTPase) at two levels. Activation of Rac1 results from integrin receptor engagement, while misregulation is promoted by translocation of YopE and YopT
Ka-Wing Wong, Ralph R Isberg
doaj   +2 more sources

Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation

Molecular Oncology, EarlyView.
Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides, Sara Cristobal‐Vargas, Cristina De Ramón, Elizabeta A. Rojas, Irena Misiewicz‐Krzeminska, Isabel Isidro, José Juan Pérez, Bruno Paiva, Noemi Puig, Miguel Alcoceba, María‐Victoria Mateos, Luis A. Corchete, Myriam Cuadrado, Norma C. Gutiérrez   +13 more
wiley   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Lnc‐HZ05 Suppresses Trophoblast Cell Migrasome Formation by Disrupting TGFβ2 Pathway in Unexplained Recurrent Miscarriage

Advanced Science, EarlyView.
TGFβ2 signaling‐mediated migration/invasion and migrasome formation are suppressed in recurrent miscarriage (RM) versus healthy control villous tissues and are negatively associated with unexplained RM. In mechanism, TGFβ2 promotes trophoblast cell migration/invasion and migrasome formation, all of which are suppressed by lnc‐HZ05. In details, lnc‐HZ05
Weina Chen, Ying Zhang, Zimeng Zhao, Yang Yang, Geng Guo, Yi Sun, Tao Zhang, Zhihong Zhang, Liqin Zeng, Wenxin Huang, Qingjun Shen, Ruining Han, Zhaohui He, Depeng Zhao, Huidong Zhang   +14 more
wiley   +1 more source