CSDE1 Drives Glycolysis and the Progression of Prostate Cancer Through RAC1-Dependent RAS/MAPK Activation. [PDF]
FASEB JThe mechanism by which CSDE1 promotes prostate cancer progression through RAC1‐dependent RAS/MAPK activation and enhanced glycolysis. ABSTRACT Prostate cancer (PCa) remains a leading cause of cancer‐related morbidity and mortality among men, necessitating the elucidation of molecular drivers behind its progression.
Yin Z +12 more
europepmc +2 more sources
Granule Cell Dispersion in Human Temporal Lobe Epilepsy: Proteomics investigation of neurodevelopmental migratory pathways [PDF]
, 2020 Granule cell dispersion (GCD) is a common pathological feature observed in the hippocampus of patients with Mesial Temporal Lobe Epilepsy (MTLE). Pathomechanisms underlying GCD remain to be elucidated, but one hypothesis proposes aberrant reactivation of
Al-Kaaby, B. +11 more
core +1 more source
The formin FHOD1 and the small GTPase Rac1 promote vaccinia virus actin-based motility [PDF]
, 2013 Vaccinia virus dissemination relies on the N-WASP– ARP2/3 pathway, which mediates actin tail formation underneath cell-associated extracellular viruses (CEVs).
Alberts +79 more
core +2 more sources
RhoB regulates cell migration through altered focal adhesion dynamics [PDF]
Open Biology, 2012 The Rho GTPase RhoB has been shown to affect cell migration, but how it does this is not clear. Here we show that cells depleted of RhoB by RNAi are rounded and have defects in Rac-mediated spreading and lamellipodium extension, although they have active
Francisco M. Vega +4 more
doaj +1 more source
FilGAP, a GAP for Rac1, down-regulates invadopodia formation in breast cancer cells
Cell Structure and Function, 2023 Invadopodia are protrusive structures that mediate the extracellular matrix (ECM) degradation required for tumor invasion and metastasis. Rho small GTPases regulate invadopodia formation, but the molecular mechanisms of how Rho small GTPase activities ...
Koji Saito +8 more
doaj +1 more source
A role for the small GTPases RAC1 and RAC1b in the modulation of NIS expression: potentiation of therapy with radioactive iodine in differentiated thyroid carcinoma [PDF]
, 2019 Introduction or Background: The Sodium Iodide Symporter (NIS) is responsible for active transport of iodide into thyroid follicular cells. The retention of its functional expression in most of the well-differentiated thyroid carcinomas (DTCs) enables ...
Bugalho, Maria J. +5 more
core +1 more source
A novel Rac1-GSPT1 signaling pathway controls astrogliosis following central nervous system injury [PDF]
, 2016 Astrogliosis (i.e. glial scar), which is comprised primarily of proliferated astrocytes at the lesion site and migrated astrocytes from neighboring regions, is one of the key reactions in determining outcomes after CNS injury.
Aiba, Atsu +12 more
core +2 more sources
Clinical Therapeutics, 2015 RAC1 is a GTPase member of the RAS superfamily, and RAC1(P29S) was recently identified as the third most common recurrent mutation in melanomas, affecting 4-7% of the patients. This is an oncogenic mutation, because the mutant protein remains mostly in its active GTP-bound form, and its ectopic expression increases the rate of normal melanocytes ...
openaire +2 more sources
Ninein is essential for apico-basal microtubule formation and CLIP-170 facilitates its redeployment to non-centrosomal microtubule organizing centres [PDF]
Open Biology, 2017 Differentiation of columnar epithelial cells involves a dramatic reorganization of the microtubules (MTs) and centrosomal components into an apico-basal array no longer anchored at the centrosome.
Deborah A. Goldspink +9 more
doaj +1 more source
IAPs as E3 ligases of Rac1 : shaping the move [PDF]
, 2012 Inhibitors of Apoptosis Proteins (IAPs) are well-studied E3 ubiquitin ligases predominantly known for regulation of apoptosis. We uncovered that IAPs can function as a direct E3 ubiquitin ligase of RhoGTPase Rac1.
Oberoi-Khanuja, Tripat Kaur +1 more
core +1 more source