Results 21 to 30 of about 45,252 (218)
Tyrosine phosphorylation of Rac1: a role in regulation of cell spreading. [PDF]
PLoS ONE, 2011 Rac1 influences a multiplicity of vital cellular- and tissue-level control functions, making it an important candidate for targeted therapeutics. The activity of the Rho family member Cdc42 has been shown to be modulated by tyrosine phosphorylation at ...
Fumin Chang +4 more
doaj +1 more source
Myotubularin MTM1 Involved in Centronuclear Myopathy and its Roles in Human and Yeast Cells [PDF]
Journal of Molecular and Genetic Medicine, OMICS International,
2015, 08 (02), 2018 Mutations in the MTM1 gene, encoding the phosphoinositide phosphatase myotubularin, are responsible for the X-linked centronuclear myopathy (XLCNM) or X-linked myotubular myopathy (XLMTM). The MTM1 gene was first identified in 1996 and its function as a PtdIns3P and PtdIns(,5)P2 phosphatase was discovered in 2000.
arxiv +1 more source
Chronic inflammation evoked by pathogenic stimulus during carcinogenesis
4 open, 2019 A pathogenic (biological or chemical) stimulus is the earliest information received by a cell that can result in the disruption of homeostasis with consequent development of disease.
Brücher Björn L.D.M., Jamall Ijaz S.
doaj +1 more source
CYRI/ Fam49 Proteins Represent a New Class of Rac1 Interactors
Communicative & Integrative Biology, 2019 Fam49 proteins, now referred to as CYRI (CYFIP-related Rac Interactor), are evolutionarily conserved across many phyla. Their closest relative by amino acid sequence is CYFIP, as both proteins contain a domain of unknown function DUF1394.
Jamie A. Whitelaw +5 more
doaj +1 more source
Nucleophosmin1 is a negative regulator of the small GTPase Rac1. [PDF]
PLoS ONE, 2013 The Rac1 GTPase is a critical regulator of cytoskeletal dynamics and controls many biological processes, such as cell migration, cell-cell contacts, cellular growth and cell division.
Younes Zoughlami +3 more
doaj +1 more source
Frontiers in Physiology, 2021 Ras-related C3 botulinum toxin substrate 1 (RAC1) activation plays a vital role in diabetic nephropathy (DN), but the exact mechanism remains unclear.
Changjiang Ying +7 more
doaj +1 more source
Regulation of cell protrusions by small GTPases during fusion of the neural folds
eLife, 2016 Epithelial fusion is a crucial process in embryonic development, and its failure underlies several clinically important birth defects. For example, failure of neural fold fusion during neurulation leads to open neural tube defects including spina bifida.
Ana Rolo +8 more
doaj +1 more source
European Journal of Neuroscience, Volume 56, Issue 12, Page 6141-6161, December 2022., 2022 Chemical synapses are tiny and overcrowded environments enriched with thousands of protein species. Many efforts have been devoted to developing sensors and actuators able to evaluate and control synaptic communication. Most of these recent tools are based on the engineering of one or more specific synaptic proteins used to target active moieties to ...
Jacopo Lamanna +3 more
wiley +1 more source
A biased random walk approach for modeling the collective chemotaxis of neural crest cells [PDF]
arXiv, 2023 Collective cell migration is a multicellular phenomenon that arises in various biological contexts, including cancer and embryo development. "Collectiveness" can be promoted by cell-cell interactions such as co-attraction and contact inhibition of locomotion. These mechanisms act on cell polarity, pivotal for directed cell motility, through influencing
arxiv
European Journal of Neurology, Volume 30, Issue 2, Page 511-526, February 2023., 2023 Abstract Background and purpose Charcot–Marie–Tooth disease (CMT) is a heterogeneous group of disorders caused by mutations in at least 100 genes. However, approximately 60% of cases with axonal neuropathies (CMT2) still remain without a genetic diagnosis. We aimed at identifying novel disease genes responsible for CMT2.
Silvia Cipriani +23 more
wiley +1 more source