Integrating metabolomics, bionics, and culturomics to study probiotics-driven drug metabolism [PDF]
Frontiers in Pharmacology, 2023 Many drugs have been shown to be metabolized by the human gut microbiome, but probiotic-driven drug-metabolizing capacity is rarely explored. Here, we developed an integrated metabolomics, culturomics, and bionics framework for systematically studying ...
Bohai Li +17 more
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Analysis of Racecadotril in Pharmaceutical Formulations Using Ultra Performance Liquid Chromatography (UPLC) Method [PDF]
Bezmiâlem Science, 2023 Objective:In this study, a simple and selective ultra-performance liquid chromatography method for the determination of racecadotril in pharmaceutical dosage forms has been developed.Methods:The method is in reverse phase C18 column; based on the ...
Armağan ÖNAL, Emrullah BİNAY
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Randomized Clinical Trial Comparing The Effect Of Oral Rehydration Therapy With And Without Racecadotril In The Management Of Acute Diarrhea In Children [PDF]
Journal of Rawalpindi Medical College, 2023 Objective: This study aimed to investigate the beneficial effect of racecadotril in children with acute diarrheal illness. Methods: This randomized case-control study was conducted at Watim General Hospital over four months from April to July 2023.
Sughra Zulfiqar +5 more
doaj +3 more sources
A comprehensive review of the pharmacodynamics, pharmacokinetics and clinical effects of the neutral endopeptidase inhibitor racecadotril [PDF]
Frontiers in Pharmacology, 2012 Racecadotril, via its active metabolite thiorphan, is an inhibitor of the enzyme neutral endopeptidase (NEP, EC 3.4.24.11), thereby increasing exposure to NEP including enkephalins and atrial natriuretic peptide.
Marion eEberlin +2 more
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Racecadotril induced bilateral uveal effusion: a case report [PDF]
BMC OphthalmologyBackground Uveal effusion is a sight threatening condition, due to possible acute angle-closure glaucoma and maculopathy. We present a case of bilateral uveal effusion after taking racecadotril, an enkephalinase inhibitor used as a medical treatment for ...
Jona Callaert +2 more
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Understanding the Anti-Diarrhoeal Properties of Incomptines A and B: Antibacterial Activity against Vibrio cholerae and Its Enterotoxin Inhibition [PDF]
Pharmaceuticals, 2022 Incomptines A (IA) and B (IB) are two sesquiterpene lactones with antiprotozoal, antibacterial, cytotoxic, antitumor, spermicidal, and phytotoxic properties.
Fernando Calzada +7 more
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Research in Pharmaceutical Sciences, 2021 Background and purpose: Although pain is one of the most common symptoms of diseases, it is often mismanaged due to limited access to painkillers and ineffectiveness, unacceptable side effects, or the possibility of abuse.
Mehdi Asadi +5 more
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Racecadotril Versus Loperamide for Acute Diarrhea of Infectious Origin in Adults: A Systematic Review and Meta‐Analysis [PDF]
Health Science ReportsBackground and Aims Loperamide and racecadotril are two antidiarrheal medications with different mechanisms of action that are highly important for the treatment of diarrhea as a result of infectious pathology.
Maryam Aziz +12 more
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Racecadotril in the management of diarrhea: an underestimated therapeutic option? [PDF]
Therapeutic Advances in GastroenterologyAcute infectious diarrhea (AID) represents an important clinical entity both regarding morbidity and mortality rates, even in industrialized countries, and it leads to one of the major public health burdens, among gastroenterological diseases, with ...
Marco Manfredi +4 more
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National Consensus for the Management of Acute Gastroenteritis in Jordanian Children: Consensus Recommendations Endorsed by the Jordanian Paediatric Society [PDF]
International Journal of Pediatrics, 2022 Diarrhoeal diseases are one of the leading worldwide preventable causes of death among children under 5 years of age. Almost half of children do not receive optimal acute gastroenteritis (AGE) treatment in Jordan.
Mohammed Rawashdeh +6 more
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