Results 21 to 30 of about 993 (170)

CRISPR/Cas9-engineering of Kell null erythrocytes to unveil host targeted irresistible antimalarial [PDF]

Communications Biology
Malaria elimination faces challenges from drug resistance, stemming from mutations within the parasite’s genetic makeup. Genetic adaptations in key erythrocyte proteins offer malaria protection in endemic regions.
Geeta Kumari, Pragya Gupta, Sangam G. Goswami, Ravi Jain, Sakshi Anand, Shreeja Biswas, Swati Garg, Priya Thakur, Vinodh Saravanakumar, V. R. Arvinden, Bidhan Goswami, Ipsita Pal Bhowmick, Narla Mohandas, Jeremy Burrows, Sivaprakash Ramalingam, Shailja Singh   +15 more
doaj   +2 more sources

Prediction and identification of synergistic compound combinations against pancreatic cancer cells. [PDF]

iScience, 2021
Resistance to current therapies is common for pancreatic cancer and hence novel treatment options are urgently needed. In this work, we developed and validated a computational method to select synergistic compound combinations based on transcriptomic ...
KalantarMotamedi Y, Choi RJ, Koh SB, Bramhall JL, Fan TP, Bender A.   +5 more
europepmc   +5 more sources

Adherence to treatment guidelines for acute diarrhoea in children up to 12 years in Ujjain, India - a cross-sectional prescription analysis [PDF]

BMC Infectious Diseases, 2011
Background Diarrhoea accounts for 20% of all paediatric deaths in India. Despite WHO recommendations and IAP (Indian Academy of Paediatrics) and Government of India treatment guidelines, few children suffering from acute diarrhoea in India receive low ...
Marrone Gaetano, Pathak Ashish, Pathak Deepali, Diwan Vishal, Lundborg Cecilia   +4 more
doaj   +4 more sources

Cost utility, budget impact, and scenario analysis of racecadotril in addition to oral rehydration for acute diarrhea in children in Malaysia [PDF]

ClinicoEconomics and Outcomes Research, 2018
Tamlyn Anne Rautenberg,1,2 Ute Zerwes,3 Way Seah Lee4 1IGES Institut GmbH, Berlin, Germany; 2Health Economics and HIV/AIDS Research Division (HEARD), University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa; 3Assessment in Medicine GmbH, Lö ...
Rautenberg TA, Zerwes U, Lee WS
doaj   +2 more sources

Concomitant medication in patients with bradykinin‐mediated angioedema – there's more than ACE inhibitors

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 21, Issue 11, Page 1283-1289, November 2023., 2023
Summary Bradykinin‐mediated angioedema is a rare, non‐allergic, potentially life‐threatening disease. ACE inhibitor‐induced angioedema and hereditary angioedema (HAE) are the two most common presentations. Therapeutic options, pathophysiology and diagnosis continue to be investigated, with considerable progress in HAE over the last few decades. For all
Robin Lochbaum, Thomas K. Hoffmann, Jens Greve, Janina Hahn   +3 more
wiley   +1 more source

Medikamente als Auslöser Bradykinin‐vermittelter Angioödeme – mehr als ACE‐Hemmer

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 21, Issue 11, Page 1283-1290, November 2023., 2023
Zusammenfassung Bradykinin‐vermittelte Angioödeme sind seltene, nichtallergische und potenziell lebensbedrohliche Krankheiten. Die beiden bekanntesten Formen sind das ACE‐Hemmer‐induzierte Angioödem und das hereditäre Angioödem (HAE). Die therapeutischen Möglichkeiten, die Pathophysiologie und die Diagnostik werden weiter erforscht, wobei beim HAE in ...
Robin Lochbaum, Thomas K. Hoffmann, Jens Greve, Janina Hahn   +3 more
wiley   +1 more source

Hospital Based Prospective Observational Study to Audit the Prescription Practices and Outcomes of Paediatric Patients (6 months to 5 years age group) Presenting with Acute Diarrhea [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: Diarrhea is a leading killer of children, accounting for 9% of all deaths among under-five children worldwide. WHO protocol deviation in management of diarrheas in children is likely due to various reasons.
Tapobrata De, Santosh Kondekar, Surbhi Rathi   +2 more
doaj   +1 more source

Recent progress in orodispersible films‐mediated therapeutic applications: A review

MedComm – Biomaterials and Applications, Volume 2, Issue 2, June 2023., 2023
The current therapeutic applications of orodispersible films (ODFs) are delivered either locally or systemically for potential patients suffering from various diseases, including oral inflammation, cardiovascular diseases, pain disorders, nausea and vomiting, mood or mental disorders, erectile dysfunction and pulmonary diseases Abstract Orodispersible ...
Yu Tian, Jiangtao Lin, Hongshu Jing, Quan Wang, Zhihua Wu, Yourong Duan   +5 more
wiley   +1 more source

Effects of neprilysin and neprilysin inhibitors on glucose homeostasis: Controversial points and a promising arena 脑啡肽酶和脑啡肽酶抑制剂对葡萄糖稳态的影响:一个有争议的观点和有前景的领域

Journal of Diabetes, Volume 15, Issue 5, Page 397-408, May 2023., 2023
Highlights Neprilysin (NEP) inhibitors may lead to beneficial effects through inhibition of NEP, which involves impairment of glucose homeostasis through modulation of insulin resistance and the development of pancreatic β cell dysfunction as observed in type 2 diabetes mellitus.
Faisal Holil AlAnazi, Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb, Athanasios Alexiou, Marios Papadakis, Hanan A. Ogaly, Yousef Abud Alanazi, Hebatallah M. Saad, Gaber El‐Saber Batiha   +8 more
wiley   +1 more source

ACUTE GASTROENTERITIS IN CHILDREN-THERAPEUTIC PRINCIPLES [PDF]

Romanian Journal of Pediatrics, 2008
This report presents updated recommendations for the optimal management of acute gastroenteritis in childhood, according to fundamental therapeutical principles recommended by ESPGHAN ( European Society of Paediatric Gastroenterology, Hepatology and ...
Victoria Hurduc, Valeriu Popescu, Dimitrie Dragomir, Doina Pleșca, Luiza Preda   +4 more
doaj   +1 more source