Results 1 to 10 of about 48,920 (145)

Time-Dependent Induction of the Nucleotide Excision Repair Gene XPA and RAD51 in Homologous Recombination in Human Lymphocytes Exposed to Low Doses of Ionizing Radiation [PDF]

Iranian Journal of Medical Physics, 2022
Introduction: The aim of the present study was to understand the effect of low-doses of ionizing radiation (LDIR) on repair genes expression in blood samples that were taken from healthy donors.
Mohammad Taghi Bahreyni Toossi, Sara Khademi, Hosein Azimian   +2 more
doaj   +1 more source

UHRF1 Controls the Timing of RAD51 Removal During DNA Damage Repair Through Suppressing RFWD3 [PDF]

Advanced Science
The RAD51 recombinase is evolutionarily conserved critical for homologous recombination (HR)‐mediated repair of DNA double‐strand breaks. It binds to single strand DNA to form protein‐DNA filaments for homology searching and pairing during HR repair ...
Guangxue Liu, Kaiyan Huang, Shiyao Liu, Ziyu Sheng, Pumin Zhang   +4 more
doaj   +2 more sources

RAD51 wrestles with SUMO

Molecular & Cellular Oncology, 2022
RAD51 loading onto chromatin is a key step during the homologous recombination (HR) repair. We recently reported a new mode of RAD51 regulation, which is mediated by TOPORS E3 SUMO ligase and RAD51 SUMOylation.
Younghoon Kee, Jung-Hee Lee, Ho Jin You
doaj   +1 more source

Identification of key enzalutamide-resistance-related genes in castration-resistant prostate cancer and verification of RAD51 functions

Open Medicine, 2023
Patients with castration-resistant prostate cancer (CRPC) often develop drug resistance after treatment with enzalutamide. The goal of our study was to identify the key genes related to enzalutamide resistance in CRPC and to provide new gene targets for ...
Xu Wen, Liu Li, Cui Zhongqi, Li Mingyang, Ni Jinliang, Huang Nan, Zhang Yue, Luo Jie, Sun Limei, Sun Fenyong   +9 more
doaj   +1 more source

Characterization of t-loop formation by TRF2

Nucleus, 2020
T-loops are thought to hide telomeres from DNA damage signaling and DSB repair pathways. T-loop formation requires the shelterin component TRF2, which represses ATM signaling and NHEJ.
Leonid A. Timashev, Titia De Lange
doaj   +1 more source

Clinicopathological and Prognostic Characteristics of RAD51 in Colorectal Cancer

Medicina, 2020
Background and Objectives: RAD51 plays an essential role in DNA repair via homologous recombination. RAD51 facilitates strand transfer between interrupted sequences and their undamaged homologies. Therefore, we studied the RAD51 mRNA expression levels in
Jae-Ho Lee, An-Na Bae, Soo-Jung Jung
doaj   +1 more source

Predictive value of RAD51 on the survival and drug responsiveness of ovarian cancer

Cancer Cell International, 2021
Background Ovarian cancer has greatly endangered and deteriorated female health conditions worldwide. Refinement of predictive biomarkers could enable patient stratification and help optimize disease management.
Yuchen Feng, Daoqi Wang, Luyang Xiong, Guohua Zhen, Jiahong Tan   +4 more
doaj   +1 more source

Direct and indirect control of the initiation of meiotic recombination by DNA damage checkpoint mechanisms in budding yeast [PDF]

, 2013
Meiotic recombination plays an essential role in the proper segregation of chromosomes at meiosis I in many sexually reproducing organisms. Meiotic recombination is initiated by the scheduled formation of genome-wide DNA double-strand breaks (DSBs).
AJ MacQueen, AL Goldstein, BH Lee, Bilge Argunhan, C Buhler, CY Bonilla, E Martini, EF Joyce, G Vader, H Sasanuma, H Sun, H Toyoizumi, H Tsubouchi, H-C Ho, H-Y Wu, HG Blitzblau, Hideo Tsubouchi, Hiroshi Toyoizumi, J Lange, JC Harrison, JE Haber, JL Gerton, KA Henderson, KS Tung, L Wan, L Xu, L Zou, M Lichten, M Lisby, M Petronczki, Michael Lichten, MJ Neale, Neil Humphryes, S Chu, S Farmer, S Farmer, S Keeney, Sarah Farmer, Tomomi Tsubouchi, Wing-Kit Leung, Yaroslav Terentyev   +40 more
core   +12 more sources

Inhibition of autophagy aggravates DNA damage response and gastric tumorigenesis via Rad51 ubiquitination in response to H. pylori infection

Gut Microbes, 2020
Helicobacter pylori (H. pylori) infection is the strongest known risk factor for the development of gastric cancer. DNA damage response (DDR) and autophagy play key roles in tumorigenic transformation. However, it remains unclear how H.
Chuan Xie, Nianshuang Li, Huan Wang, Cong He, Yi Hu, Chao Peng, Yaobin Ouyang, Dejie Wang, Yong Xie, Jiang Chen, Xu Shu, Yin Zhu, Nonghua Lu   +12 more
doaj   +1 more source

RAD51 is essential for spermatogenesis and male fertility in mice

Cell Death Discovery, 2022
The recombinase RAD51 catalyzes the DNA strand exchange reaction in homologous recombination (HR) during both mitosis and meiosis. However, the physiological role of RAD51 during spermatogenesis remains unclear since RAD51 null mutation is embryonic ...
Junchao Qin, Tao Huang, Jing Wang, Limei Xu, Qianli Dang, Xiuhua Xu, Hongbin Liu, Zhaojian Liu, Changshun Shao, Xiyu Zhang   +9 more
doaj   +1 more source