Homologous Recombination: To Fork and Beyond [PDF]
, 2018 Accurate completion of genome duplication is threatened by multiple factors that hamper the advance and stability of the replication forks. Cells need to tolerate many of these blocking lesions to timely complete DNA replication, postponing their repair ...
Prado Velasco, José Félix
core +1 more source
DNA damage induced during mitosis undergoes DNA repair synthesis. [PDF]
, 2020 Understanding the mitotic DNA damage response (DDR) is critical to our comprehension of cancer, premature aging and developmental disorders which are marked by DNA repair deficiencies.
Berns, Michael W +10 more
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RAD51 paralogs synergize with RAD51 to protect reversed forks from cellular nucleases
Nucleic Acids Research, 2023 Abstract Fork reversal is a conserved mechanism to prevent stalled replication forks from collapsing. Formation and protection of reversed forks are two crucial steps in ensuring fork integrity and stability. Five RAD51 paralogs, namely, RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3, which share sequence and structural similarity to the ...
Chia-Lun Guh +8 more
openaire +2 more sources
Crystal structure of Hop2-Mnd1 and mechanistic insights into its role in meiotic recombination [PDF]
, 2015 In meiotic DNA recombination, the Hop2-Mnd1 complex promotes Dmc1-mediated single-stranded DNA (ssDNA) invasion into homologous chromosomes to form a synaptic complex by a yet-unclear mechanism.
Alexandra-Styliani Kalantzi +66 more
core +3 more sources
PALB2 self-interaction controls homologous recombination. [PDF]
, 2012 PALB2 is essential for BRCA2 anchorage to nuclear structures and for homologous recombinational repair of DNA double-strand breaks. Here, we report that the N-terminal coiled-coil motif of PALB2 regulates its self-association and homologous recombination.
Buisson, Rémi, Masson, Jean-Yves
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Mechanism of Replication Fork Reversal and Protection by Human RAD51 and RAD51 Paralogs [PDF]
SSRN Electronic Journal, 2020 Abstract SMARCAL1, ZRANB3 and HLTF are all required for the remodeling of replication forks upon stress. Using reconstituted reactions, we show that the motor proteins have unequal biochemical capacities, explaining why they have non-redundant functions.
Petr Cejka +9 more
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SUMOylation of Rad52-Rad59 synergistically change the outcome of mitotic recombination [PDF]
, 2016 Homologous recombination (HR) is essential for maintenance of genome stability through double-strand break (DSB) repair, but at the same time HR can lead to loss of heterozygosity and uncontrolled recombination can be genotoxic.
Lisby, Michael, Silva, Sonia
core +1 more source
G3: Genes, Genomes, Genetics, 2019 Candida albicans, the most common fungal pathogen, is a diploid with a genome that is rich in repeats and has high levels of heterozygosity. To study the role of different recombination pathways on direct-repeat recombination, we replaced either allele ...
Alberto Bellido +5 more
doaj +1 more source
Interactions between BRCA2 and RAD51 for promoting homologous recombination in Leishmania infantum. [PDF]
, 2012 In most organisms, the primary function of homologous recombination (HR) is to allow genome protection by the faithful repair of DNA double-strand breaks.
Buisson, Rémi +9 more
core +2 more sources
Comprehensive Analysis of the Expression and Prognosis for RAD51 Family in Human Breast Cancer
International Journal of General Medicine, 2022 Yaqin Shi,1,* Meng Shen,1,* Mengdan Xu,1 Min Tao,1 Kai Chen,1 Qingqing Zhu2 1Department of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China; 2Department of Respiratory Medicine, The First ...
Shi Y +5 more
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