Results 41 to 50 of about 49,012 (231)

RAD54 family translocases counter genotoxic effects of RAD51 in human tumor cells. [PDF]

, 2015
The RAD54 family DNA translocases have several biochemical activities. One activity, demonstrated previously for the budding yeast translocases, is ATPase-dependent disruption of RAD51-dsDNA binding.
Bishop, Douglas K, Budke, Brian, Connell, Philip P, Dusad, Kritika, Grubb, Jennifer, Heyer, Wolf-Dietrich, Mason, Jennifer M, Weichselbaum, Ralph R, Wright, William Douglass   +8 more
core   +2 more sources

Molecular Determinant of DIDS Analogs Targeting RAD51 Activity

Molecules, 2021
RAD51 is the central protein in DNA repair by homologous recombination (HR), involved in several steps of this process. It is shown that overexpression of the RAD51 protein is correlated with increased survival of cancer cells to cancer treatments.
Denis Velic, Alexandre Demeyer, Thibaut Peterlini, Houda Benhelli-Mokrani, Monique Mathé-Allainmat, Jean-Yves Masson, Fabrice Fleury   +6 more
doaj   +1 more source

Functional significance of the Rad51-Srs2 complex in Rad51 presynaptic filament disruption [PDF]

Nucleic Acids Research, 2009
The SRS2 (Suppressor of RAD Six screen mutant 2) gene encodes an ATP-dependent DNA helicase that regulates homologous recombination in Saccharomyces cerevisiae. Mutations in SRS2 result in a hyper-recombination phenotype, sensitivity to DNA damaging agents and synthetic lethality with mutations that affect DNA metabolism.
Colavito, Sierra, Macris-Kiss, Margaret, Seong, Changhyun, Gleeson, Olive, Greene, Eric C., Klein, Hannah L., Krejci, Lumir, Sung, Patrick   +7 more
openaire   +2 more sources

Trypanosoma brucei BRCA2 acts in a life cycle-specific genome stability process and dictates BRC repeat number-dependent RAD51 subnuclear dynamics [PDF]

, 2012
Trypanosoma brucei survives in mammals through antigenic variation, which is driven by RAD51-directed homologous recombination of Variant Surface Glycoproteins (VSG) genes, most of which reside in a subtelomeric repository of >1000 silent genes. A key
Alsford, Anna Trenaman, Ayoub, Becker, Bennett, Bork, Bringaud, Brough, Callejas, Carlos R. Machado, Carreira, Carreira, Chung, Claire Hartley, Danielle G. Passos-Silva, Daniels, Davies, Davies, Dobson, Dray, Dumont, Esashi, Esashi, Futamura, Genois, Giloni, Glover, Hartley, Hashimoto, Heyer, Jackson, Jeyasekharan, Kim, Kim, Ko, Kojic, Kojic, Kojic, Lee, Lisby, Lo, Lord, Marcello, Marko Prorocic, Marmorstein, McCulloch, McKean, McKean, Melville, Mizuta, Moniek van den Hoek, Morrison, Munday, Oyola, Park, Petalcorin, Proudfoot, Raz, Regis-da-Silva, Renzette, Richard McCulloch, Robinson, Saeki, Schlacher, Shivji, Tarsounas, Tarsounas, Vink, Volodymyr Nechyporuk-Zloy, Yu, Zeiner, Zhou   +71 more
core   +1 more source

A Pan-Cancer Bioinformatic Analysis of RAD51 Regarding the Values for Diagnosis, Prognosis, and Therapeutic Prediction

Frontiers in Oncology, 2022
BackgroundRAD51, a critical protein for DNA repairment, has been found to associate with multiple cancer types, but, so far, a systematic pan-cancer analysis of RAD51 has not been done yet.MethodsData were obtained from multiple open databases and ...
Hengrui Liu, Jieling Weng
doaj   +1 more source

The RAD51-FFPE Test

Cancers, 2021
PARP inhibitor (PARPi) sensitivity is related to tumor-specific defects in homologous recombination (HR). Therefore, there is great clinical interest in tests that can rapidly and reliably identify HR deficiency (HRD). Functional HRD tests determine the actual HR status by using the (dis)ability to accumulate RAD51 protein at sites of DNA damage as ...
Wijk, Lise M. van, Kramer, Claire J. H., Vermeulen, Sylvia, Haar, Natalja T. ter, Jonge, Marthe M. de, Kroep, Judith R., Kroon, Cor D. de, Gaarenstroom, Katja N., Vrieling, Harry, Bosse, Tjalling, Vreeswijk, Maaike P. G.   +10 more
openaire   +1 more source

Combination BET Family Protein and HDAC Inhibition Synergistically Elicits Chondrosarcoma Cell Apoptosis Through RAD51-Related DNA Damage Repair

Cancer Management and Research, 2020
Songwei Huan,1,* Tao Gui,1,* Qiutong Xu,1,* Songkuan Zhuang,2 Zhenyan Li,1 Yuling Shi,3 Jiebin Lin,3 Bin Gong,1 Guiqiang Miao,1 Manseng Tam,4 Huan-Tian Zhang,1 Zhengang Zha,1 Chunfei Wu3 1Institute of Orthopedic Diseases and Department of Bone and Joint ...
Huan S, Gui T, Xu Q, Zhuang S, Li Z, Shi Y, Lin J, Gong B, Miao G, Tam M, Zhang HT, Zha Z, Wu C   +12 more
doaj  

E2F1-regulated long non-coding RNA RAD51-AS1 promotes cell cycle progression, inhibits apoptosis and predicts poor prognosis in epithelial ovarian cancer

Scientific Reports, 2017
Long non-coding RNA RAD51 antisense RNA 1 (RAD51-AS1, also known as TODRA) has been shown to be down-regulated by E2F1, a key cell cycle and apoptosis regulator, in breast cancer. Little is known regarding the role of RAD51-AS1 in disease.
Xiaodan Zhang, Guoping Liu, Junjun Qiu, Ning Zhang, Jingxin Ding, Keqin Hua   +5 more
doaj   +1 more source

Overexpression of Rad51 Predicts Poor Prognosis in Colorectal Cancer: Our Experience with 54 Patients. [PDF]

PLoS ONE, 2017
BACKGROUND:Aberrant Rad51 expression is implicated in the progression of human malignancies. However, the role of Rad51 in colorectal cancer (CRC) remains undefined.
Yan Li, Wei-Ya Wang, Jiang-Hong Xiao, Feng Xu, Dian-Ying Liao, Li Xie, Jin Wang, Feng Luo   +7 more
doaj   +1 more source

Congenital mirror movements in a new Italian family [PDF]

, 2014
Mirror movements (MMs) occur on the contralateral side of a limb being used intentionally. Because few families with congenital MMs and no other neurological signs have been reported, the underlying mechanisms of MMs are still not entirely clear.
Berardelli, Alfredo, Bologna, Matteo, Colonnese, Claudio, DI BIASIO, Francesca, Fasano, Alfonso, Grillea, Giovanni, Iezzi, Ennio, Levert, Annie, Pavone, Luigi, Rouleau, Guy A., Sebastiano, Fabio, Srour, Myriam   +11 more
core   +1 more source