Results 61 to 70 of about 890,751 (309)
, 2010 We present the latest advances of the multiscale approach to radiation damage caused by irradiation of a tissue with energetic ions and report the most recent advances in the calculations of complex DNA damage and the effects of thermal spikes on ...
Solov'yov, A. V. +2 more
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Metals, 2020 Safe and long term operation of nuclear reactors is one of the most discussed challenges in nuclear power engineering. The radiation degradation of nuclear design materials limits the operational lifetime of all nuclear installations or at least ...
Vladimír Slugeň +5 more
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Protective effects of leaf juice of Brassica rapa on radio-damage of mouse
浙江大学学报. 农业与生命科学版, 2001 The protection and repair effects of Brassica rapa leaf juice on radio-damage mouse induced by 60Coγ-rays were studied with the methods of measuring hemogram of mice, classifying of WBC, measuring wieght of the spleens and chest glands, and the ...
QIAN Xiao-wei +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Nanomaterials, 2020 AlN-based ceramics have great prospects for use in the field of structural materials for reactors of the new generation of GenIV, as well as dosimetric and optical devices.
Artem L. Kozlovskiy +2 more
doaj +1 more source
Cumulative Radiation Damage and Cumulative Radiation Effect [PDF]
Acta Radiologica: Oncology, 1983 Different mathematical formulas capable of replacing CRE have been analyzed. The purpose was to develop an expression which would yield a value identical with CRE for regular treatment schedules, but would represent more clearly and more truthfully the radiation damage of tissue. This quantity has been called cumulative radiation damage (CRD). Its unit
openaire +2 more sources
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Effect of DNA Damage on the Development of Diabetes Mellitus due toIonizing Radiation Exposure
Academic Science JournalExposure to ionizing radiation destroys several biological processes by disturbing the membranes of cells and causing damage to DNA, proteins, and mitochondria.
Lina Al-jameel +4 more
doaj +1 more source