Results 1 to 10 of about 3,391 (203)

Sultones for Radiofluorination and Bioconjugation: Fluorine-18 Labeling of Native Proteins and Glycoproteins [PDF]

ACS Omega
Aliphatic nucleophilic substitution of a sulfonate ester group (such as triflate, mesylate, tosylate, or nosylate) represents a prominent reaction in fluorine-18 chemistry, as illustrated by the radiosynthesis of [18F]FDG (fluorodeoxyglucose) routinely ...
Anne-Elodie Lafargue, Clémence Maingueneau, Benoit Bernay, Abdelaziz Ejjoummany, Cécile Perrio   +4 more
doaj   +4 more sources

Generic semi-automated radiofluorination strategy for single domain antibodies: [18F]FB-labelled single domain antibodies for PET imaging of fibroblast activation protein-α or folate receptor-α overexpression in cancer [PDF]

EJNMMI Radiopharmacy and Chemistry
Background Radiofluorination of single domain antibodies (sdAbs) via N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB) has shown to be a promising strategy in the development of sdAb-based PET tracers. While automation of the prosthetic group (PG) [18F]SFB
Herlinde Dierick, Laurent Navarro, Hannelore Ceuppens, Thomas Ertveldt, Ana Rita Pombo Antunes, Marleen Keyaerts, Nick Devoogdt, Karine Breckpot, Matthias D’Huyvetter, Tony Lahoutte, Vicky Caveliers, Jessica Bridoux   +11 more
doaj   +4 more sources

Effective Preparation of [¹⁸F]Flumazenil Using Copper-Mediated Late-Stage Radiofluorination of a Stannyl Precursor [PDF]

Molecules, 2022
(1) Background: [18F]Flumazenil 1 ([18F]FMZ) is an established positron emission tomography (PET) radiotracer for the imaging of the gamma-aminobutyric acid (GABA) receptor subtype, GABAA in the brain.
Mohammad B. Haskali, Peter D. Roselt, Terence J. O’Brien, Craig A. Hutton, Idrish Ali, Lucy Vivash, Bianca Jupp   +6 more
doaj   +3 more sources

Radiofluorination of a highly potent ATM inhibitor as a potential PET imaging agent [PDF]

EJNMMI Research, 2022
Purpose Ataxia telangiectasia mutated (ATM) is a key mediator of the DNA damage response, and several ATM inhibitors (ATMi) are currently undergoing early phase clinical trials for the treatment of cancer.
Claudia Rose Fraser, Javier Ajenjo, Mathew Veal, Gemma Marie Dias, Chung Chan, Edward O’Neill, Gianluca Destro, Doreen Lau, Anna Pacelli, Veronique Gouverneur, Rebekka Hueting, Bart Cornelissen   +11 more
doaj   +3 more sources

Bifunctional Hexadentate Pyclen-Based Chelating Agent for Mild Radiofluorination in Aqueous Solution at Room Temperature with a Ga-¹⁸F Ternary Complex. [PDF]

Chemistry
Positron Emission Tomography (PET) is used in oncology for tumor diagnosis, commonly relying on fluorine‐18 (18F) emission detection. The conventional method of 18F incorporation on to probes by covalent bonding is harsh for sensitive biomolecules, which
Dioury F, San C, Gnanalingam G, Henoumont C, Rousselin Y, Haouz A, Shepard W, Hosten B, Vijayakumar K, Laurent S, Port M.   +10 more
europepmc   +4 more sources

Manufacturing 6-[¹⁸F]Fluoro-<i>L</i>-DOPA via Flow Chemistry-Enhanced Photoredox Radiofluorination. [PDF]

Org Lett
In this study, we introduce a practical methodology for the synthesis of PET probes by seamlessly combining flow chemistry with photoredox radiofluorination.
Wu X, Chen W, Deng H, Wang L, Nicewicz DA, Li Z, Wu Z.   +6 more
europepmc   +4 more sources

The hydrogenation side-reaction in copper-mediated radiofluorination [PDF]

EJNMMI Radiopharmacy and Chemistry
Background Copper-mediated radiofluorination (CMRF) is a breakthrough in 18F-radiochemistry, enabling 18F incorporation into molecules even at electron-rich aromatic positions. In recent years, several improved protocols have been reported to advance the
Sarandeep Kaur, Barbara Wenzel, Ramona Oehme, Claudia Wiesner, Klaus Kopka, Rareş-Petru Moldovan   +5 more
doaj   +3 more sources

Development of [¹⁸F]F-5-OMe-Tryptophans through Photoredox Radiofluorination: A New Method to Access Tryptophan-Based PET Agents [PDF]

Journal of Medicinal Chemistry, 2023
Although various radiolabeled tryptophan analogs have been developed to monitor tryptophan metabolism using positron emission tomography (PET) for various human diseases including melanoma and other cancers, their application can be limited due to the ...
Xuedan Wu, Xinrui Ma, Yaofeng Desmond Zhong, Wei Chen, Muyun Xu, He Zhang, Li Wang, Xianshuang Tu, Zhaoguo Han, Weiling Zhao, Zhanhong Wu, Stergios J. Moschos, Zibo Li   +12 more
openalex   +2 more sources

Optimization of a 1,4,7‐Triazacyclononane‐1,4‐diacetic acid (NODA) Derivative Radiofluorination by Al¹⁸F Complexation Using a Design of Experiments Approach [PDF]

Chemistry, 2023
Fluorine-18 (18F) is the most favorable positron emitter for radiolabeling Positron Emission Tomography (PET) probes. However, conventional 18F labeling through covalent C-F bond formation is challenging, involving multiple steps and stringent conditions
Carine San, Benoît Hosten, N. Vignal, Meriem Beddek, Maurice Pillet, Laure Sarda‐Mantel, Marc Port, Fabienne Dioury   +7 more
openalex   +2 more sources

Lewis Acid-Facilitated Radiofluorination of MN3PU: A LRRK2 Radiotracer [PDF]

Molecules, 2020
Background: Temperature-sensitive radiopharmaceutical precursors require lower reaction temperatures (
Noeen Malik, Shreya Bendre, Ralf Schirrmacher, Paul Schaffer   +3 more
doaj   +2 more sources