Results 91 to 100 of about 3,496 (254)

τBu₂SiF-Derivatized D₂-Receptor Ligands: The First SiFA-Containing Small Molecule Radiotracers for Target-Specific PET-Imaging [PDF]

, 2011
The synthesis, radiolabeling and in vitro evaluation of new silicon-fluoride acceptor (SiFA) derivatized D-2-receptor ligands is reported. The SiFA-technology simplifies the introduction of fluorine-18 into target specific biomolecules for Positron ...
Bartenstein, Peter, Höfner, Georg, Iovkova-Berends, Ljuba, Jurkschat, Klaus, Kostikov, Alexey, Rensch, Christian, Schirrmacher, Ralf, Wanner, Klaus Theodor, Wängler, Björn, Wängler, Carmen, Zöller, Thomas   +10 more
core   +2 more sources

Catalyst-Free Aromatic Radiofluorination via Oxidized Iodoarene Precursors

Organic Letters, 2018
Oxidized iodoarenes (OIAs), prepared via mCPBA-mediated oxidation, have been demonstrated as versatile precursors for the synthesis of [18F]fluoroarenes in the absence of catalysts. OIAs have been identified as intermediates in single-pot syntheses of iodonium salts and ylides but have never been recognized as radiofluorination precursors.
Young-Do Kwon, Jeongmin Son, Joong-Hyun Chun   +2 more
openaire   +3 more sources

Double‐Click Strategy Combining CuAAC and (Thia‐) Diels‐Alder Reactions; Application Toward Peptide Labeling

Chemistry – A European Journal, Volume 31, Issue 41, July 22, 2025.
A double click‐strategy combining copper‐catalyzed azide‐alkyne cycloaddition with (thia‐)Diels‐Alder reactions involving a reactive s‐cis‐constrained diene is reported. Three different one‐pot protocols (i.e., sequential or three‐component reactions) are proposed and offer valuable guidance for future applications.
Timothé Maujean, Camille Van Wesemael, Laurine Tual, Valentine Le Berruyer, Blanca Rodriguez‐Noguer, Nicolas Girard, Dominique Bonnet, Mihaela Gulea   +7 more
wiley   +1 more source

Nucleophilic Radiofluorination Using Tri-tert-Butanol Ammonium as a Bifunctional Organocatalyst: Mechanism and Energetics

Molecules, 2022
We present a quantum chemical analysis of the 18F-fluorination of 1,3-ditosylpropane, promoted by a quaternary ammonium salt (tri-(tert-butanol)-methylammonium iodide (TBMA-I) with moderate to good radiochemical yields (RCYs), experimentally observed by ...
Young-Ho Oh, Sandip S. Shinde, Sungyul Lee   +2 more
doaj   +1 more source

Automation of a Positron-emission Tomography (PET) Radiotracer Synthesis Protocol for Clinical Production. [PDF]

, 2018
The development of new positron-emission tomography (PET) tracers is enabling researchers and clinicians to image an increasingly wide array of biological targets and processes.
Collins, Jeffrey, Drake, Christopher, Schopf, Eric, Slavik, Roger, van Dam, R Michael, Waldmann, Christopher M   +5 more
core  

NHC-Copper Mediated Ligand-Directed Radiofluorination of Aryl Halides

Journal of the American Chemical Society, 2020
[18F]-labeled aryl fluorides are widely used as radiotracers for positron emission tomography (PET) imaging. Aryl halides (ArX) are particularly attractive precursors to these radiotracers, as they are readily available, inexpensive, and stable. However, to date, the direct preparation of [18F]-aryl fluorides from aryl halides remains limited to SNAr ...
Liam S. Sharninghausen, Allen F. Brooks, Wade P. Winton, Katarina J. Makaravage, Peter J. H. Scott, Melanie S. Sanford   +5 more
openaire   +3 more sources

Pioneering Metal‐Free Late‐Stage C−H Functionalization Using Acridinium Salt Photocatalysis

Chemistry – A European Journal, Volume 30, Issue 67, December 2, 2024.
Organic dyes are powerful photocatalysts in organic transformations due to their availability, adaptable absorption, and diverse structures. Acridinium‐based organo‐photocatalysts, notable for visible light responsiveness, efficiently functionalize inert C−H bonds under mild conditions without transition metals.
Shyamal Kanti Bera, Andrea Porcheddu
wiley   +1 more source

Nucleophilic Synthesis of 6-l-[¹⁸F]FDOPA. Is Copper-Mediated Radiofluorination the Answer?

Molecules, 2020
Positron emission tomography employing 6-l-[18F]fluoro-3,4-dihydroxyphenylalanine (6-l-[18F]FDOPA) is currently a highly relevant clinical tool for detection of gliomas, neuroendocrine tumors and evaluation of Parkinson’s disease progression.
Raisa N. Krasikova
doaj   +1 more source

Copper-Mediated Radiofluorination of Arylstannanes with [¹⁸F]KF

Organic Letters, 2016
A copper-mediated nucleophilic radiofluorination of aryl- and vinylstannanes with [18F]KF is described. This method is fast, uses commercially available reagents, and is compatible with both electron-rich and electron-deficient arene substrates. This method has been applied to the manual synthesis of a variety of clinically relevant radiotracers ...
Makaravage, Katarina J., Brooks, Allen F., Mossine, Andrew V., Sanford, Melanie S., Scott, Peter J. H.   +4 more
openaire   +2 more sources

Imaging Microglial/Macrophage Activation in Spinal Cords of Experimental Autoimmune Encephalomyelitis Rats by Positron Emission Tomography Using the Mitochondrial 18kDa Translocator Protein Radioligand [18F]DPA-714 [PDF]

, 2012
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the CNS. Activated microglia/macrophages play a key role in the immunopathogenesis of MS and its corresponding animal models, experimental autoimmune encephalomyelitis (EAE).
Abourbeh, Galith, Boisgard, Raphael, Brulon, Vincent, Dollé, Frédéric, Dubois, Albertine, Fontyn, Yoann, Maroy, Renaud, Tavitian, Bertrand, Thézé, Benoit   +8 more
core   +2 more sources