Results 91 to 100 of about 3,410 (215)
Molecules, 2012 The semisynthetic oripavine derivative phenethyl orvinol (PEO), a full agonist at opioid receptors (OR), is an attractive structural motif for developing 18F-labeled PET tracers with a high degree of sensitivity for competition between endogenous and ...
Gjermund Henriksen, János Marton
doaj +1 more source
Zur Synthese von 6[18F]Fluor-L-DOPA durch nukleophile 18F-Fluorierung Carbonyl-aktivierter aromatischer Aminosäurederivate [PDF]
, 2001 6-[$^{18}$F]Fluoro-L-3,4-dihydroxyphenylalanine (6-[$^{18}$F]fluoro-L-DOPA), an analogue of L-DOPA, is an established radiotracer for diagnostic PET-studies of the integrity and function of the nigrostriatal dopaminergic system. The use of this important
Tierling, Thomas
core
Scalable 18F Processing Conditions for Copper-Mediated Radiofluorination Chemistry Facilitate "Design of Experiments" (DoE) Optimization Studies and Afford an Improved Synthesis of [18F]Olaparib. [PDF]
, 2021 Gregory D. Bowden +3 more
openalex +2 more sources
Late-Stage Copper-Catalyzed Radiofluorination of an Arylboronic Ester Derivative of Atorvastatin
Molecules, 2019 There is an unmet need for late-stage 18F-fluorination strategies to label molecules with a wide range of relevant functionalities to medicinal chemistry, in particular (hetero)arenes, aiming to obtain unique in vivo information on the pharmacokinetics ...
Gonçalo S. Clemente +3 more
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Imaging of pain using positron emission tomography
iRADIOLOGY, Volume 2, Issue 3, Page 339-361, June 2024.In this review, the positron emission tomography (PET) tracers that are used in pain imaging are summarized. These PET tracers can be utilized to visualize glucose metabolism, cerebral blood flow, bone metabolic activity, neurotransmitter receptor occupancy, ion channel expression level, enzyme activity, chaperone protein expression level ...
Yu‐Peng Zhou +3 more
wiley +1 more source
BMC Medical Imaging, 2019 Purpose The inflammation reaction in the brain may stimulate damage repair or possibly lead to secondary brain injury. It is often associated with activated microglia, which would overexpress 18-kDa translocator protein (TSPO).
Chun-Yi Wu +6 more
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Development of Pyridothiophene Compounds for PET Imaging of α‐Synuclein
Chemistry – A European Journal, Volume 30, Issue 23, April 22, 2024.47 derivatives of a potent α‐synuclein aggregate binding pyridothiophene (asyn‐44) were synthesized and screened against [3H]asyn‐44 in competitive binding assays using post‐mortem Parkinsons disease brain homogenates and Ki values of the most potent compounds were determined.
Anna Pees +8 more
wiley +1 more source
Molecules, 2020 [18F]FPEB is a positron emission tomography (PET) radiopharmaceutical used for imaging the abundance and distribution of mGluR5 in the central nervous system (CNS).
Cassis Varlow +7 more
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[18F]DPA-714 as a biomarker for positron emission tomography imaging of rheumatoid arthritis in an animal model. [PDF]
, 2014 International audienceINTRODUCTION: Rheumatoid arthritis (RA) is a chronic disease, affecting 0.5-1% of adults in industrialized countries, in which systemic inflammation and synovitis drive joint destruction.
Bernards, Nicholas +3 more
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Journal of Labelled Compounds and Radiopharmaceuticals, Volume 67, Issue 4, Page 155-164, April 2024.Validation of mGluR5 PET tracer [18F]FPEB using aryl‐chloro precursor. The radioligand [18F]FPEB, used for PET imaging of the brain's metabotropic glutamate receptor subtype 5 (mGluR5), undergoes a thorough validation process to ensure its safety, efficacy, and quality for clinical use.
Mahabuba Jahan +4 more
wiley +1 more source