Results 11 to 20 of about 3,496 (254)

Automated Solid-Phase Radiofluorination Using Polymer-Supported Phosphazenes [PDF]

Molecules, 2013
The polymer supported phosphazene bases PS-P2tBu and the novel PS-P2PEG allowed for efficient extraction of [18F]F− from proton irradiated [18O]H2O and subsequent radiofluorination of a broad range of substrates directly on the resin.
Bente Mathiessen, Fedor Zhuravlev
doaj   +4 more sources

Development of [18F]F-5-OMe-Tryptophans through Photoredox Radiofluorination: A New Method to Access Tryptophan-Based PET Agents. [PDF]

Journal of Medicinal Chemistry, 2023
Although various radiolabeled tryptophan analogs have been developed to monitor tryptophan metabolism using positron emission tomography (PET) for various human diseases including melanoma and other cancers, their application can be limited due to the ...
Xuedan Wu, Xinrui Ma, Yaofeng Desmond Zhong, Wei Chen, Muyun Xu, He Zhang, Li Wang, Xianshuang Tu, Zhaoguo Han, Wei-ming Zhao, Zhanhong Wu, S. Moschos, Zibo Li   +12 more
semanticscholar   +2 more sources

Effective Preparation of [¹⁸F]Flumazenil Using Copper-Mediated Late-Stage Radiofluorination of a Stannyl Precursor [PDF]

Molecules, 2022
(1) Background: [18F]Flumazenil 1 ([18F]FMZ) is an established positron emission tomography (PET) radiotracer for the imaging of the gamma-aminobutyric acid (GABA) receptor subtype, GABAA in the brain.
Mohammad B. Haskali, Peter D. Roselt, Terence J. O’Brien, Craig A. Hutton, Idrish Ali, Lucy Vivash, Bianca Jupp   +6 more
doaj   +2 more sources

Ethyl Pinacol Boronates as Advantageous Precursors for Copper-Mediated Radiofluorination. [PDF]

Org Lett
(Hetero)aryl pinacol boronic esters are routinely used for 18F-labeling and have accelerated numerous diagnostic and drug discovery programs. An analysis of the current state-of-play, however, highlights a pending challenge.
Hadjipaschalis N, Ortalli S, Chen Z, Paton RS, Ford J, Tredwell M, Gouverneur V.   +6 more
europepmc   +2 more sources

Optimization Study of a NODA Derivative Radiofluorination by Al18F Complexation Using a Design of Experiments Approach. [PDF]

Chemistry, 2023
Fluorine-18 (18F) is the most favorable positron emitter for radiolabeling Positron Emission Tomography (PET) probes. However, conventional 18F labeling through covalent C-F bond formation is challenging, involving multiple steps and stringent conditions
C. San, B. Hosten, N. Vignal, Meriem Beddek, Maurice Pillet, L. Sarda-Mantel, M. Port, Fabienne Dioury   +7 more
semanticscholar   +2 more sources

Fully Automated Production of (((S)-1-Carboxy-5-(6-([¹⁸F]fluoro)-2-methoxynicotinamido)pentyl)carbamoyl)-l-glutamic Acid ([¹⁸F]JK-PSMA-7) [PDF]

Pharmaceuticals
Background: The radiotracer [18F]JK-PSMA-7, a prostate cancer imaging agent for positron emission tomography (PET), was previously synthesized by indirect radiofluorination using an 18F-labeled active ester as a prosthetic group, which had to be isolated
Philipp Krapf, Thomas Wicher, Boris D. Zlatopolskiy, Johannes Ermert, Bernd Neumaier   +4 more
doaj   +2 more sources

A Comprehensive Review of Non-Covalent Radiofluorination Approaches Using Aluminum [¹⁸F]fluoride: Will [¹⁸F]AlF Replace ⁶⁸Ga for Metal Chelate Labeling? [PDF]

Molecules, 2019
Due to its ideal physical properties, fluorine-18 turns out to be a key radionuclide for positron emission tomography (PET) imaging, for both preclinical and clinical applications.
Cyril Fersing, Ahlem Bouhlel, Christophe Cantelli, Philippe Garrigue, Vincent Lisowski, Benjamin Guillet   +5 more
doaj   +2 more sources

Development of Customized [18F]Fluoride Elution Techniques for the Enhancement of Copper-Mediated Late-Stage Radiofluorination [PDF]

Scientific Reports, 2017
In a relatively short period of time, transition metal-mediated radiofluorination reactions have changed the PET radiochemistry landscape. These reactions have enabled the radiofluorination of a wide range of substrates, facilitating access to ...
Andrew V. Mossine, Allen F. Brooks, Naoko Ichiishi, Katarina J. Makaravage, Melanie S. Sanford, Peter J. H. Scott   +5 more
doaj   +2 more sources

Triflyl [¹⁸F]Fluoride as a Solution for Base-Sensitive Late-Stage Nucleophilic Aromatic ¹⁸F-Fluorination Reactions. [PDF]

Chemistry
Here, we present the late‐stage nucleophilic 18F‐fluorination of (hetero)aryls under low‐base conditions using triflyl [18F]fluoride. This method avoids the application of base and cryptand and enabled the efficient radiolabeling of a broad scope of (hetero)arenes and the successful production of clinical doses of [18F]mFBG, [18F]SynVesT‐1 and [18F ...
Haveman LYF, de Kruijff AMT, van Eeden SPP, Windhorst AD, Vugts DJ.   +4 more
europepmc   +2 more sources

¹⁸F-Radiopharmaceutical Diversification Enabled by Deaminative Cross-Electrophile Couplings. [PDF]

Angew Chem Int Ed Engl
A general Ni‐mediated (C)sp2–(C)sp3 cross‐coupling expedites access to 18F‐radiopharmaceuticals, essential for positron emission tomography imaging and drug discovery. This late‐stage diversification approach was implemented across three user‐friendly automated protocols affording 18F‐radiotracers in sufficient quantities for imaging.
Ogilvy IF, Ford J, Ortalli S, Renders E, Hayes TR, Liu S, Mortiers I, Nikolopoulou A, Sorlin AM, Trabanco AA, Tredwell M, Buijnsters PJJA, Salter R, Gouverneur V.   +13 more
europepmc   +2 more sources