Simple and Efficient Synthesis of N-Succinimidyl-4-[18F]fluorobenzoate ([18F]SFB)—An Important Intermediate for the Introduction of Fluorine-18 into Complex Bioactive Compounds [PDF]
PharmaceuticalsBackground: N-succinimidyl-[18F]fluorobenzoate ([18F]SFB) is commonly prepared through a three-step procedure starting from [18F]fluoride ion. A number of methods for the single-step radiosynthesis of [18F]SFB have been introduced recently, including the
Viktoriya V. Orlovskaya +3 more
doaj +2 more sources
Automation of Copper-Mediated 18F-Fluorination of Aryl Pinacol Boronates Using 4-Dimethylaminopyridinium Triflate [PDF]
MoleculesCurrently, the copper-mediated radiofluorination of aryl pinacol boronates (arylBPin) using the commercially available, air-stable Cu(OTf)2Py4 catalyst is one of the most efficient synthesis approaches, greatly facilitating access to a range of ...
Mikhail A. Nadporojskii +4 more
doaj +2 more sources
Solid-phase supported direct 18F-radiofluorination of peptides. [PDF]
Bioorganic & Medicinal Chemistry LettersThe absence of universal and expedient labeling procedures hampers the widespread application of peptides as molecular tracers for positron emission tomography (PET). In this work, we have developed a proof-of-concept direct radiofluorination procedure for peptides using conventional solid-phase peptide synthesis.
Eduardo F.A. Fernandes +4 more
semanticscholar +3 more sources
Investigation on the isotopic exchange radiofluorination of the pentafluorosulfanyl group.
Org Biomol ChemThe pentafluorosulfanyl group (–SF5) is one of the most promising fluorinated functional groups, recently developed as an alternative to the trifluoromethyl group (–CF3) in drug design.
Hiscocks H +12 more
europepmc +2 more sources
Radiofluorination of a highly potent ATM inhibitor as a potential PET imaging agent [PDF]
EJNMMI Research, 2022 Purpose Ataxia telangiectasia mutated (ATM) is a key mediator of the DNA damage response, and several ATM inhibitors (ATMi) are currently undergoing early phase clinical trials for the treatment of cancer.
Claudia Rose Fraser +11 more
doaj +2 more sources
On the Risk of <sup>18</sup>F-Regioisomer Formation in the Copper-Free Radiofluorination of Aryliodonium Precursors. [PDF]
Org Lett, 2023 Aryliodonium precursors are widely applied for copper-free labeling of positron emission tomography (PET) tracers with fluorine-18. We assessed 18F-fluoroarene regioisomer formation in examples of these labeling methods.
Zhao Q +4 more
europepmc +2 more sources
Al18F: A New Standard for Radiofluorination [PDF]
Journal of Nuclear Medicine, 2013 TO THE EDITOR: 18F is the most common radionuclide used in PET imaging, but its application via a rapid, simple, easily accessible labeling procedure has been challenging. We congratulate Wan et al.
David M. Goldenberg +3 more
openalex +4 more sources
Nanomaterials, 2023 This study describes the synthesis, radiofluorination and purification of an anionic amphiphilic teroligomer developed as a stabilizer for siRNA-loaded calcium phosphate nanoparticles (CaP-NPs).
Barbara Wenzel +10 more
doaj +2 more sources
Exploration of Directing-Group-Assisted, Copper-Mediated Radiofluorination and Radiosynthesis of [18F]Olaparib. [PDF]
ACS Med Chem Lett, 2023 Copper-mediated radiofluorination (CMRF) of organoboronic precursors is the method of choice for late-stage radiofluorination of aromatic compounds as positron emission tomography (PET) radiotracers.
Zhou D, Chu W, Chen H, Xu J.
europepmc +2 more sources
[18F]-Radiolabelled Nanoplatforms: A Critical Review of Their Intrinsic Characteristics, Radiolabelling Methods, and Purification Techniques [PDF]
MoleculesA wide range of nano-objects is found in many applications of our everyday life. Recognition of their peculiar properties and ease of functionalization has prompted their engineering into multifunctional platforms that are supposed to afford efficient ...
Maëlle Deleuziere +4 more
doaj +2 more sources