Results 21 to 30 of about 3,410 (215)

Synthesis, Structure–Activity Relationships, Radiofluorination, and Biological Evaluation of [¹⁸F]RM365, a Novel Radioligand for Imaging the Human Cannabinoid Receptor Type 2 (CB2R) in the Brain with PET

Journal of Medicinal Chemistry, 2023
The development of cannabinoid receptor type 2 (CB2R) PET radioligands has been intensively explored due to the pronounced CB2R upregulation under various pathological conditions.
Rodrigo Teodoro, Daniel Gündel, Winnie Deuther‐Conrad, Aleksandr Kazimir, Magali Toussaint, Barbara Wenzel, Guy Bormans, Evamarie Hey‐Hawkins, Klaus Kopka, Peter Brust, Rareş‐Petru Moldovan   +10 more
openalex   +2 more sources

Automated radiofluorination of HER2 single domain antibody: the road towards the clinical translation of [¹⁸F]FB-HER2 sdAb. [PDF]

EJNMMI Radiopharm Chem
With the next generation of Human Epidermal Growth Factor Receptor 2 (HER2) -targeting therapies, such as antibody–drug conjugates, showing benefit in “HER2 low” and even “HER2 ultralow” patients, the need for novel methods to quantify HER2 expression ...
Dierick H, Navarro L, Van den Block S, Saliën J, Lahoutte T, Caveliers V, Bridoux J.   +6 more
europepmc   +2 more sources

Ethyl Pinacol Boronates as Advantageous Precursors for Copper-Mediated Radiofluorination. [PDF]

Org Lett
(Hetero)aryl pinacol boronic esters are routinely used for 18F-labeling and have accelerated numerous diagnostic and drug discovery programs. An analysis of the current state-of-play, however, highlights a pending challenge.
Hadjipaschalis N, Ortalli S, Chen Z, Paton RS, Ford J, Tredwell M, Gouverneur V.   +6 more
europepmc   +2 more sources

Phosphonate-Based Aza-Macrocycle Ligands for Low-Temperature, Stable Chelation of Medicinally Relevant Rare Earth Radiometals and Radiofluorination. [PDF]

J Am Chem Soc
Radioisotopes of fluorine (18F), scandium (43/44Sc, 47Sc), lutetium (177Lu), and yttrium (86Y, 90Y) have decay properties ideally suited for targeted nuclear imaging and therapy with small biologics, such as peptides and antibody fragments.
Whetter JN, Śmiłowicz D, Becker KV, Aluicio-Sarduy E, Kelderman CAA, Koller AJ, Glaser OM, Marlin A, Ahn SH, Kretowicz MN, Engle JW, Boros E.   +11 more
europepmc   +2 more sources

Closing the gap between 19F and 18F chemistry [PDF]

EJNMMI Radiopharmacy and Chemistry, 2021
Positron emission tomography (PET) has become an invaluable tool for drug discovery and diagnosis. The positron-emitting radionuclide fluorine-18 is frequently used in PET radiopharmaceuticals due to its advantageous characteristics; hence, methods ...
Javier Ajenjo, Gianluca Destro, Bart Cornelissen, Véronique Gouverneur   +3 more
doaj   +2 more sources

[¹⁸F]-Radiolabelled Nanoplatforms: A Critical Review of Their Intrinsic Characteristics, Radiolabelling Methods, and Purification Techniques [PDF]

Molecules
A wide range of nano-objects is found in many applications of our everyday life. Recognition of their peculiar properties and ease of functionalization has prompted their engineering into multifunctional platforms that are supposed to afford efficient ...
Maëlle Deleuziere, Éric Benoist, Isabelle Quelven, Emmanuel Gras, Catherine Amiens   +4 more
doaj   +2 more sources

Expanding tracer space for positron emission tomography with high molar activity 18F-labeled α,α-difluoromethylalkanes [PDF]

Nature Communications
Positron emission tomography (PET) is an advanced biomedical imaging modality that relies on well-designed radiotracers to report on specific protein targets and processes occurring in living animals and humans. Cyclotron-produced short-lived fluorine-18
Qunchao Zhao, Sanjay Telu, Shuiyu Lu, Victor W. Pike   +3 more
doaj   +2 more sources

¹⁸F-Labeled, PSMA-Targeted Radiotracers: Leveraging the Advantages of Radiofluorination for Prostate Cancer Molecular Imaging [PDF]

Theranostics, 2019
Prostate-specific membrane antigen (PSMA)-targeted PET imaging for prostate cancer with 68Ga-labeled compounds has rapidly become adopted as part of routine clinical care in many parts of the world.
Rudolf A. Werner, Thorsten Derlin, Constantin Lapa, Sara Sheikbahaei, Takahiro Higuchi, Frederik L. Giesel, Spencer C. Behr, Alexander Drzezga, Hiroyuki Kimura, Andreas K. Buck, Frank M. Bengel, Martin G. Pomper, Michael A. Gorin, Steven P. Rowe   +13 more
openalex   +2 more sources

Preparation and Preclinical Evaluation of ¹⁸F-Labeled Olutasidenib Derivatives for Non-Invasive Detection of Mutated Isocitrate Dehydrogenase 1 (mIDH1) [PDF]

Molecules
Mutations of isocitrate dehydrogenase 1 (IDH1) are key biomarkers for glioma classification, but current methods for detection of mutated IDH1 (mIDH1) require invasive tissue sampling and cannot be used for longitudinal studies.
Roberta Cologni, Marcus Holschbach, Daniela Schneider, Dirk Bier, Annette Schulze, Carina Stegmayr, Heike Endepols, Johannes Ermert, Felix Neumaier, Bernd Neumaier   +9 more
doaj   +2 more sources

Synthesis of a [¹⁸F]F Estradiol Derivative via Click Chemistry Using an Automated Synthesis Module: In Vitro Evaluation as Potential Radiopharmaceutical for Breast Cancer Imaging [PDF]

Pharmaceuticals
“Click reactions” are a very useful tool for the selective conjugation of different molecular subunits to produce complex structures in a simple way. In this paper, we present the application of Cu(I)-catalyzed biorthogonal reactions between alkynes and ...
María Emilia Tejería, María Pía Pereira, Juan Pablo Gambini, Pablo Duarte, Javier Gabriel Giglio, Ana María Rey   +5 more
doaj   +2 more sources