Results 31 to 40 of about 3,410 (215)

Photoredox Nucleophilic (Radio)fluorination of Alkoxyamines. [PDF]

J Am Chem Soc
Herein, we report a photoredox nucleophilic (radio)­fluorination using TEMPO-derived alkoxyamines, a class of substrates accessible in a single step from a diversity of readily available carboxylic acids, halides, alkenes, alcohols, aldehydes, boron ...
Ortalli S, Ford J, Trabanco AA, Tredwell M, Gouverneur V.   +4 more
europepmc   +3 more sources

Late-stage (radio)fluorination of alkyl phosphonates via electrophilic activation [PDF]

Nature Communications
Constructing organic fluorophosphines, vital drug skeletons, through the direct fluorination of readily available alkyl phosphonates has been impeded due to the intrinsic low electrophilicity of PV and the high bond energy of P═O bond.
Kaiqiang Zhang, Wanru Feng, Zhaobiao Mou, Lei Zhang, Mengting Ma, Zixiao Zhao, Xia Liu, Xiaoyuan Chen, Zijing Li   +8 more
doaj   +2 more sources

Tandem Iridium-Catalyzed C-H Borylation/Copper-Mediated Radiofluorination of Aromatic C-H Bonds with [¹⁸F]TBAF. [PDF]

Methods Mol Biol
Morales M, Preshlock S, Sharninghausen LS, Wright JS, Brooks AF, Sanford MS, Scott PJH.   +6 more
europepmc   +2 more sources

Triflyl [¹⁸F]Fluoride as a Solution for Base-Sensitive Late-Stage Nucleophilic Aromatic ¹⁸F-Fluorination Reactions. [PDF]

Chemistry
Here, we present the late‐stage nucleophilic 18F‐fluorination of (hetero)aryls under low‐base conditions using triflyl [18F]fluoride. This method avoids the application of base and cryptand and enabled the efficient radiolabeling of a broad scope of (hetero)arenes and the successful production of clinical doses of [18F]mFBG, [18F]SynVesT‐1 and [18F ...
Haveman LYF, de Kruijff AMT, van Eeden SPP, Windhorst AD, Vugts DJ.   +4 more
europepmc   +2 more sources

Mild, Organo-Catalysed Borono-Deamination as a Key to Late-Stage Pharmaceutical Precursors and 18F-Labelled Radiotracers

Frontiers in Chemistry, 2022
A tris(pentafluorophenyl)borane catalysed method for the synthesis of boronic acid esters from aromatic amines in yields of up to 93% was devised.
Raúl M. Pérez-García, Patrick J. Riss, Patrick J. Riss, Patrick J. Riss, Patrick J. Riss   +4 more
doaj   +1 more source

Radiosynthesis of 5-[¹⁸F]Fluoro-1,2,3-triazoles through Aqueous Iodine–[¹⁸F]Fluorine Exchange Reaction

Molecules, 2021
In this report, a simple and efficient process to achieve fluorine-18-labeled 1,2,3-triazole is reported. The heteroaromatic radiofluorination was successfully achieved through an iodine–fluorine-18 exchange in an aqueous medium requiring only trace ...
Xiang Zhang, Falguni Basuli, Sameh Abdelwahed, Tadhg Begley, Rolf Swenson   +4 more
doaj   +1 more source

Efforts toward PET-Activatable Red-Shifted Silicon Rhodamines and Silicon Pyronine Dyes

Pharmaceuticals, 2023
Tracers for bimodal optical imaging and positron emission tomography unite multiple advantages in a single molecule. Their tumor-specific uptake can be visualized after their PET activation by radiofluorination via PET/CT or PET/MRI allowing for staging ...
Carsten Sven Kramer, Thines Kanagasundaram, Jessica Matthias, Klaus Kopka   +3 more
doaj   +1 more source

Automated Optimized Synthesis of [¹⁸F]FLT Using Non-Basic Phase-Transfer Catalyst with Reduced Precursor Amount

Molecules, 2022
3′-deoxy-3′-[18F]fluorothymidine ([18F]FLT) is a positron emission tomography (PET) tracer useful for tumor proliferation assessment for a number of cancers, particularly in the cases of brain, lung, and breast tumors.
Olga S. Fedorova, Viktoriya V. Orlovskaya, Raisa N. Krasikova   +2 more
doaj   +1 more source

One-Pot Radiosynthesis of [¹⁸F]Anle138b—5-(3-Bromophenyl)-3-(6-[¹⁸F]fluorobenzo[d][1,3]dioxol-5-yl)-1H-pyrazole—A Potential PET Radiotracer Targeting α-Synuclein Aggregates

Molecules, 2023
Availability of PET imaging radiotracers targeting α-synuclein aggregates is important for early diagnosis of Parkinson’s disease and related α-synucleinopathies, as well as for the development of new therapeutics.
Viktoriya V. Orlovskaya, Olga S. Fedorova, Nikolai B. Viktorov, Daria D. Vaulina, Raisa N. Krasikova   +4 more
doaj   +1 more source

MODIFICATION OF [18F]FDG BY THE FORMATION OF A HYDRAZONE BOND [PDF]

Journal of IMAB, 2023
Purpose: The [18F]-fluorodeoxyglucose ([18F]-FDG) is known to be one of the most used radio-pharmaceuticals for positron emission tomography. [18F]-FDG allows the assessment of glycolytic activity, which is more enhanced in tumor cells than in normal ...
Gergana Simeonova, Boyan Todorov
doaj   +1 more source