Angewandte Chemie International Edition, Volume 63, Issue 26, June 21, 2024.Herein, we disclose that pyridinium salts derived from abundant (hetero)anilines represent a novel precursor class for nucleophilic aromatic substitution reactions with [18F]fluoride.
Joseph Ford +5 more
semanticscholar +2 more sources
18F-Labeled, PSMA-Targeted Radiotracers: Leveraging the Advantages of Radiofluorination for Prostate Cancer Molecular Imaging [PDF]
Theranostics, 2020 Prostate-specific membrane antigen (PSMA)-targeted PET imaging for prostate cancer with 68Ga-labeled compounds has rapidly become adopted as part of routine clinical care in many parts of the world.
R. Werner +13 more
semanticscholar +2 more sources
Expanding tracer space for positron emission tomography with high molar activity 18F-labeled α,α-difluoromethylalkanes [PDF]
Nature CommunicationsPositron emission tomography (PET) is an advanced biomedical imaging modality that relies on well-designed radiotracers to report on specific protein targets and processes occurring in living animals and humans. Cyclotron-produced short-lived fluorine-18
Qunchao Zhao +3 more
doaj +2 more sources
Journal of Medicinal Chemistry, 2023 The development of cannabinoid receptor type 2 (CB2R) PET radioligands has been intensively explored due to the pronounced CB2R upregulation under various pathological conditions.
R. Teodoro +10 more
semanticscholar +2 more sources
Expedient Access to 18F‐Fluoroheteroarenes via Deaminative Radiofluorination of Aniline‐Derived Pyridinium Salts [PDF]
Angewandte Chemie, Volume 136, Issue 26, June 21, 2024.18F‐Fluoroheteroarenes find wide application as radiotracers for PET (positron emission tomography) imaging. Here, we present a deaminative radiosynthetic approach via pyridinium tetrafluoroborates that facilitates radiofluorination of 33 structurally diverse heteroarenes in up to 98 % RCY (radiochemical yield).
Joseph Ford +5 more
openalex +2 more sources
Preparation and Preclinical Evaluation of 18F-Labeled Olutasidenib Derivatives for Non-Invasive Detection of Mutated Isocitrate Dehydrogenase 1 (mIDH1) [PDF]
MoleculesMutations of isocitrate dehydrogenase 1 (IDH1) are key biomarkers for glioma classification, but current methods for detection of mutated IDH1 (mIDH1) require invasive tissue sampling and cannot be used for longitudinal studies.
Roberta Cologni +9 more
doaj +2 more sources
Phosphonate-Based Aza-Macrocycle Ligands for Low-Temperature, Stable Chelation of Medicinally Relevant Rare Earth Radiometals and Radiofluorination. [PDF]
J Am Chem SocRadioisotopes of fluorine (18F), scandium (43/44Sc, 47Sc), lutetium (177Lu), and yttrium (86Y, 90Y) have decay properties ideally suited for targeted nuclear imaging and therapy with small biologics, such as peptides and antibody fragments.
Whetter JN +11 more
europepmc +2 more sources
Electrochemical radiofluorination using a split-bipolar electrode
Journal of Fluorine Chemistryidentifier:oai:t2r2.star.titech.ac.jp ...
Tomoyuki Kurioka +8 more
semanticscholar +3 more sources
Closing the gap between 19F and 18F chemistry [PDF]
EJNMMI Radiopharmacy and Chemistry, 2021 Positron emission tomography (PET) has become an invaluable tool for drug discovery and diagnosis. The positron-emitting radionuclide fluorine-18 is frequently used in PET radiopharmaceuticals due to its advantageous characteristics; hence, methods ...
Javier Ajenjo +3 more
doaj +2 more sources
Synthesis of a [18F]F Estradiol Derivative via Click Chemistry Using an Automated Synthesis Module: In Vitro Evaluation as Potential Radiopharmaceutical for Breast Cancer Imaging [PDF]
Pharmaceuticals“Click reactions” are a very useful tool for the selective conjugation of different molecular subunits to produce complex structures in a simple way. In this paper, we present the application of Cu(I)-catalyzed biorthogonal reactions between alkynes and ...
María Emilia Tejería +5 more
doaj +2 more sources