Results 51 to 60 of about 3,496 (254)

Automated Optimized Synthesis of [¹⁸F]FLT Using Non-Basic Phase-Transfer Catalyst with Reduced Precursor Amount

Molecules, 2022
3′-deoxy-3′-[18F]fluorothymidine ([18F]FLT) is a positron emission tomography (PET) tracer useful for tumor proliferation assessment for a number of cancers, particularly in the cases of brain, lung, and breast tumors.
Olga S. Fedorova, Viktoriya V. Orlovskaya, Raisa N. Krasikova   +2 more
doaj   +1 more source

One-Pot Radiosynthesis of [¹⁸F]Anle138b—5-(3-Bromophenyl)-3-(6-[¹⁸F]fluorobenzo[d][1,3]dioxol-5-yl)-1H-pyrazole—A Potential PET Radiotracer Targeting α-Synuclein Aggregates

Molecules, 2023
Availability of PET imaging radiotracers targeting α-synuclein aggregates is important for early diagnosis of Parkinson’s disease and related α-synucleinopathies, as well as for the development of new therapeutics.
Viktoriya V. Orlovskaya, Olga S. Fedorova, Nikolai B. Viktorov, Daria D. Vaulina, Raisa N. Krasikova   +4 more
doaj   +1 more source

MODIFICATION OF [18F]FDG BY THE FORMATION OF A HYDRAZONE BOND [PDF]

Journal of IMAB, 2023
Purpose: The [18F]-fluorodeoxyglucose ([18F]-FDG) is known to be one of the most used radio-pharmaceuticals for positron emission tomography. [18F]-FDG allows the assessment of glycolytic activity, which is more enhanced in tumor cells than in normal ...
Gergana Simeonova, Boyan Todorov
doaj   +1 more source

Fluorine-18-Labeled Fluorescent Dyes for Dual-Mode Molecular Imaging

Molecules, 2020
Recent progress realized in the development of optical imaging (OPI) probes and devices has made this technique more and more affordable for imaging studies and fluorescence-guided surgery procedures.
Maxime Munch, Benjamin H. Rotstein, Gilles Ulrich   +2 more
doaj   +1 more source

Reaction of [18F]Fluoride at Heteroatoms and Metals for Imaging of Peptides and Proteins by Positron Emission Tomography

Frontiers in Chemistry, 2021
The ability to radiolabel proteins with [18F]fluoride enables the use of positron emission tomography (PET) for the early detection, staging and diagnosis of disease.
Kymberley R. Scroggie, Michael V. Perkins, Justin M. Chalker   +2 more
doaj   +1 more source

Recent Advances in ¹⁸F-Labeled Amino Acids Synthesis and Application

Pharmaceutics, 2022
Radiolabeled amino acids are an important class of agents for positron emission tomography imaging that target amino acid transporters in many tumor types.
Chao Wang, Rong Lin, Shaobo Yao
doaj   +1 more source

A Convenient Route to New (Radio)Fluorinated and (Radio)Iodinated Cyclic Tyrosine Analogs

Pharmaceuticals, 2022
The use of radiolabeled non-natural amino acids can provide high contrast SPECT/PET metabolic imaging of solid tumors. Among them, radiohalogenated tyrosine analogs (i.e., [123I]IMT, [18F]FET, [18F]FDOPA, [123I]8-iodo-L-TIC(OH), etc.) are of particular ...
Maria Noelia Chao, Jean-Michel Chezal, Eric Debiton, Damien Canitrot, Tiffany Witkowski, Sophie Levesque, Françoise Degoul, Sébastien Tarrit, Barbara Wenzel, Elisabeth Miot-Noirault, Audrey Serre, Aurélie Maisonial-Besset   +11 more
doaj   +1 more source

Synthesis, in vitro and in vivo evaluation of 3β-[18F]fluorocholic acid for the detection of drug-induced cholestasis in mice [PDF]

, 2017
Introduction : Drug-induced cholestasis is a liver disorder that might be caused by interference of drugs with the hepatobiliary bile acid transporters. It is important to identify this interference early on in drug development.
De Lombaerde, Stef, De Vos, Filip, Devisscher, Lindsey, Kersemans, Ken, Neyt, Sara, Van Vlierberghe, Hans, Vanhove, Christian, Verhoeven, Jeroen   +7 more
core   +3 more sources

Recent Advances in Synthetic Methodologies to Form C-18F Bonds

Frontiers in Chemistry, 2022
Positron emission tomography (PET) is an important technique for the early diagnosis of disease. Due to the specific physical and chemical properties of Fluorine-18, this important isotope is widely used in PET for labelling and molecular imaging, and ...
Zhiyi Liu, Zhiyi Liu, Yijun Sun, Yijun Sun, Tianfei Liu, Tianfei Liu, Tianfei Liu   +6 more
doaj   +1 more source

Synthesis of 18F-labelled 2-fluoro-1,4-quinones using acetylhypofluorite [PDF]

, 1988
The fluorination of 1,4-benzo- and naphthoquinones using [18F]acetylhypofluorite is described.
Herscheid, Jacobus D.M., Verboom, Willem, Visser, Gerard W.M., Wedzinga, Rinny   +3 more
core   +3 more sources