Results 61 to 70 of about 3,410 (215)
Optimization of PET protocol and interrater reliability of 18F-PSMA-11 imaging of prostate cancer [PDF]
, 2020 Background Several scan parameters for PET imaging with F-18-PSMA-11 such as dosage, acquisition time and scan duration were evaluated to determine the most appropriate scan protocol, as well as the effect of furosemide administration on lesion ...
Achten, Eric +7 more
core +2 more sources
Molecules, 2016 Nitric oxide (NO), an important multifunctional signaling molecule, is produced by three isoforms of NO-synthase (NOS) and has been associated with neurodegenerative disorders.
Christian Drerup +2 more
doaj +1 more source
Isotopic Radiolabeling of the Antiretroviral Drug [18F]Dolutegravir for Pharmacokinetic PET Imaging
Pharmaceuticals, 2022 Deciphering the drug/virus/host interactions at infected cell reservoirs is a key leading to HIV-1 remission for which positron emission tomography (PET) imaging using radiolabeled antiretroviral (ARV) drugs is a powerful asset. Dolutegravir (DTG) is one
Marion Tisseraud +9 more
doaj +1 more source
Development of novel fluorine-18 labeled PET radioligands for monoamine oxidase B (MAO-B) [PDF]
, 2013 Monoamine oxidases (MAO-A and MAO-B) are important enzymes regulating the levels of monoaminergic neurotransmitters. Selectiv e and irreversible MAO-B inhibitors such as L -deprenyl and rasagiline are clinically used for the t reatment of ...
Nag, Sangram
core +2 more sources
Synthesis of Fluorine-18 Functionalized Nanoparticles for use as in vivo Molecular Imaging Agents [PDF]
, 2008 Nanoparticles containing fluorine-18 were prepared from block copolymers made by ring opening metathesis polymerization (ROMP). Using the fast initiating ruthenium metathesis catalyst (H_2IMes)(pyr)_2(Cl)_2Ru=CHPh, low polydispersity amphiphilic block ...
, X. K. +54 more
core +3 more sources
Electrochemically Generated Carbocations in Organic Synthesis
Angewandte Chemie, Volume 136, Issue 44, October 24, 2024.This Minireview examines a selection of case studies that showcase distinctive and enabling electrochemical approaches that have allowed for the generation and reaction of carbocation intermediates under mild conditions. Particular emphasis is placed on the progress that has been made in this area of organic synthesis and polymer chemistry over the ...
Bill C. Hawkins +3 more
wiley +2 more sources
SynOpen, 2017 The first prospective fluorinated PET tracers for imaging hypoxia obtained via thiazolidine-ligation are reported. Three 1,2-thiol-amine linkers were combined with four different 2-nitroimidazole spacers via amide or urea bond formation.
M. Musolino, S. Dall’Angelo, M. Zanda
doaj +1 more source
Radiosynthesis and in vivo evaluation of a 18F-labelled styryl-benzoxazole derivative for β-amyloid targeting [PDF]
, 2013 The formation of β-amyloid deposits is considered a histopathological feature of Alzheimer′s disease (AD). In vivo molecular imaging by means of amyloid-avid radiotracers will allow for an early and conclusive diagnostic of AD.
Abrunhosa, A. +6 more
core +1 more source
Enzymatic transhalogenation of dendritic RGD peptide constructs with the fluorinase [PDF]
, 2016 We thank EPSRC and the Scottish Imaging Network (SINAPSE) for grants. DO’H thanks the Royal Society for a Wolfson Research Merit Award and ST is grateful to the John and Kathleen Watson Scholarship for financial support.
Fleming, Ian N. +2 more
core +1 more source
Angewandte Chemie, Volume 136, Issue 27, July 1, 2024.The mild and high‐yielding synthesis of 18F‐labeled aryl trifluoromethyl sulfones, ‐sulfoxides, and ‐sulfides using [18F]Ruppert‐Prakash reagent is described. The application to the radiolabeling of different bioactive compounds using >1 GBq of 18F‐labeling reagent is demonstrated.
Lukas Veth +2 more
wiley +2 more sources