Results 81 to 90 of about 3,496 (254)

Electrochemically Generated Carbocations in Organic Synthesis

Angewandte Chemie, Volume 136, Issue 44, October 24, 2024.
This Minireview examines a selection of case studies that showcase distinctive and enabling electrochemical approaches that have allowed for the generation and reaction of carbocation intermediates under mild conditions. Particular emphasis is placed on the progress that has been made in this area of organic synthesis and polymer chemistry over the ...
Bill C. Hawkins, Justin M. Chalker, Michelle L. Coote, Alex C. Bissember   +3 more
wiley   +2 more sources

Recent Advances in Bioconjugation of Aromatic Amino Acid Residues by a Reactivity‐Guided Approach

The Chemical Record, EarlyView.
This review highlights recent advances in the bioconjugation of aromatic amino acids residues, focusing on strategies that leverage their inherent chemical reactivity to enable precise and versatile modifications of biomacromolecules, illustrating relevant applications.
Bruno M. da S. Santos, Lívia C. R. M. da Frota, Thais G. Silva, Fernanda G. Finelli   +3 more
wiley   +1 more source

Synthesis of [ 18 F]fluoroethoxy‐benzovesamicol, a radiotracer for cholinergic neurons [PDF]

, 1993
Full experimental details are given for the preparation of [ 18 F]fluoroethoxy‐benzovesamicol, (−)‐( 2R, 3R )‐ trans ‐2‐hydroxy‐3‐(4‐phenylpiperidino)‐5‐(2‐[ 18 F]fluoroethoxy)‐1,2,3,4‐tetralin, a new fluorine‐18 labeled cholinergic neuron mapping agent ...
Altar, Block, Block, Chi, Dale, Efange, French, Hicks, Jerabek, Jung, Keisewetter, Kiesewetter, Kilbourn, Lemaire, Marien, Marshall, Moerlein, Mulholland, Mulholland, Mulholland, Mulholland, Mulholland, Mulholland, Plenevaux, Rogers, Rogers, Rogers, Rogers, Satymurthy, Shuie, Suehiro, Widen   +31 more
core   +1 more source

18F‐Radiopharmaceutical Diversification Enabled by Deaminative Cross‐Electrophile Couplings

Angewandte Chemie, Volume 138, Issue 4, 22 January 2026.
A general Ni‐mediated (C)sp2–(C)sp3 cross‐coupling expedites access to 18F‐radiopharmaceuticals, essential for positron emission tomography imaging and drug discovery. This late‐stage diversification approach was implemented across three user‐friendly automated protocols affording 18F‐radiotracers in sufficient quantities for imaging.
Isabella F. Ogilvy, Joseph Ford, Sebastiano Ortalli, Evelien Renders, Thomas R. Hayes, Shuanglong Liu, Inne Mortiers, Anastasia Nikolopoulou, Alexandre M. Sorlin, Andrés A. Trabanco, Matthew Tredwell, Peter J. J. A. Buijnsters, Rhys Salter, Véronique Gouverneur   +13 more
wiley   +1 more source

Untersuchungen zur trägerarmen Radiofluorierung nicht-aktivierter Aromaten mit n.c.a. [18F]Fluorid [PDF]

, 2011
In vivo imaging with positron emission tomography generally demands radiotracers with a high specific activity. In case of fluorine-18 the required no-carrier-added (n.c.a.) starting material is only available in form of fluoride. This and the short half-
Cardinale, Jens
core  

Liquid Chromatography‐Tandem Mass Spectrometry Methods for Rapid Measurement of the Molar Activity (Am) of Cyclotron‐Produced [18F]Fluoride and Derived Radiotracers

Chemistry–Methods, Volume 6, Issue 1, January 2026.
Accurate and simple liquid chromatography‐tandem mass spectrometry methods for measuring Am for [18F]fluoride on two rapidly derived surrogates, [18F]FAY and [18F]PCBSF, can serve as forensic tools for investigating the sources of carrier, Am determinations during routine tracer productions and be applied to radiotracers lacking a strong ultraviolet ...
Nicholas R. Ellin, Sean W. Costner, Cheryl L. Morse, Fatemak Ahmadi, Sanjay Telu, Fabrice G. Siméon, Shuiyu Lu, H. Umesha Shetty, Victor W. Pike   +8 more
wiley   +1 more source

Development new radiopharmaceutical based on 5-thio-d- glucose labeled technetium-99m [PDF]

, 2016
The article considers the obtaining and possibility of using 5-thio-D-glucose labeled technetium-99m for the diagnosis of malignant tumors by single photon emission computed tomography.
Ilina, Elena Sergeevna, Larionova, Lyudmila Aleksandrovna, Nesterov, Evgeny Alexandrovich, Rogov, Alexander Sergeyevich, Sadkin, Vladimir Leonidovich, Skuridin, Viktor Sergeyevich, Stasyuk (Stasiuk), Elena Sergeyevna, Varlamova, Natalya Valeryevna, Zelchan, R.   +8 more
core   +1 more source

Использование соединений поливалентного иода в получении [18F]фторсодержащих трейсеров для позитронной эмиссионной томографии [PDF]

, 2011
Впервые проведен анализ научной литературы по использованию соединений поливалентного иода в синтезе прекурсоров - иодониевых солей для введения атома [18F]фтора в структуру органических ...
Дрыгунова, Лариса Александровна, Ларькина, Мария Сергеевна, Юсубов, Мехман Сулейман-оглы (Сулейманович)   +2 more
core   +2 more sources

Synthesis of 18F‐labeled Aryl Trifluoromethyl Sulfones, ‐Sulfoxides, and ‐Sulfides for Positron Emission Tomography

Angewandte Chemie, Volume 136, Issue 27, July 1, 2024.
The mild and high‐yielding synthesis of 18F‐labeled aryl trifluoromethyl sulfones, ‐sulfoxides, and ‐sulfides using [18F]Ruppert‐Prakash reagent is described. The application to the radiolabeling of different bioactive compounds using >1 GBq of 18F‐labeling reagent is demonstrated.
Lukas Veth, Albert D. Windhorst, Danielle J. Vugts   +2 more
wiley   +2 more sources

Synthetic Strategies to Access Fluorinated Azoles

European Journal of Organic Chemistry, Volume 28, Issue 47, December 15, 2025.
This review highlights recent synthetic strategies for introducing fluorine groups (mono‐, di‐, and trifluoromethylation) into 11 major azole classes, identifying research gaps to inform future innovations in materials science, medicinal chemistry, and biomedical research.
Mohammed K. Abd El‐Gaber, Mario Djugovski, Tzu‐Yu Huang, Sweta Adhikari, Sudeshna Roy   +4 more
wiley   +1 more source