Journal of labelled compounds & radiopharmaceuticalsThe σ-1 receptor is a non-opioid transmembrane protein involved in various human pathologies including neurodegenerative diseases, inflammation, and cancer. The previously published ligand [18 F]FTC-146 is among the most promising tools for σ-1 molecular
Anna Marešová +8 more
semanticscholar +1 more source
τBu₂SiF-Derivatized D₂-Receptor Ligands: The First SiFA-Containing Small Molecule Radiotracers for Target-Specific PET-Imaging [PDF]
, 2011 The synthesis, radiolabeling and in vitro evaluation of new silicon-fluoride acceptor (SiFA) derivatized D-2-receptor ligands is reported. The SiFA-technology simplifies the introduction of fluorine-18 into target specific biomolecules for Positron ...
Bartenstein, Peter +10 more
core +2 more sources
Chemistry – A European Journal, Volume 30, Issue 55, October 1, 2024.A method was rationally optimized to minimize deleterious protodeboronation side‐product in Cu‐mediated 19F‐ and 18F‐fluorination of arylboronic acids. Fluoride anion is activated through a hydrogen bond donor (HBD) effect under ligandless conditions featuring a new copper salt, Cu(ONf)2.
Jingkai Sun +3 more
wiley +1 more source
Rapid Electrophilic 211At‐Astatination of Trimethylgermyl Arenes
ChemPlusChem, Volume 89, Issue 9, September 2024.211At‐Astatodegermylation: Different ortho‐, meta‐, and para‐substituted trimethylgermyl arenes were astatinated at low precursor amounts (0.15 μmol) in trifluoroacetic acid with an average radiochemical conversion (RCC) of ca. 50 % for electron‐rich and approx. 70 % in case of electron‐deficient arenes.
Marius Müller +7 more
wiley +1 more source
Nucleophilic Synthesis of 6-l-[18F]FDOPA. Is Copper-Mediated Radiofluorination the Answer?
Molecules, 2020 Positron emission tomography employing 6-l-[18F]fluoro-3,4-dihydroxyphenylalanine (6-l-[18F]FDOPA) is currently a highly relevant clinical tool for detection of gliomas, neuroendocrine tumors and evaluation of Parkinson’s disease progression.
Raisa N. Krasikova
doaj +1 more source
Aryl trimethylammonium trifluoromethanesulfonates as precursors to aryl [18F]fluorides [PDF]
, 1989 Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90143/1/2580260109_ftp ...
Angelini +6 more
core +1 more source
Potential of miRNA as Imaging Targets for PET
Helvetica Chimica Acta, Volume 107, Issue 8, August 2024.Abstract Positron Emission Tomography (PET) is an important part of the medical imaging field which is continually exploring novel biological targets as exemplified by PET imaging of neuroinflammation. Due to limitations stemming from either sub‐optimal biological targets or a lack of available selective radiotracers, alternative biomarkers and PET ...
Simon H. Zientek +3 more
wiley +1 more source
Automation of a Positron-emission Tomography (PET) Radiotracer Synthesis Protocol for Clinical Production. [PDF]
, 2018 The development of new positron-emission tomography (PET) tracers is enabling researchers and clinicians to image an increasingly wide array of biological targets and processes.
Collins, Jeffrey +5 more
core
Imaging Microglial/Macrophage Activation in Spinal Cords of Experimental Autoimmune Encephalomyelitis Rats by Positron Emission Tomography Using the Mitochondrial 18kDa Translocator Protein Radioligand [18F]DPA-714 [PDF]
, 2012 Multiple sclerosis (MS) is an inflammatory demyelinating disease of the CNS. Activated microglia/macrophages play a key role in the immunopathogenesis of MS and its corresponding animal models, experimental autoimmune encephalomyelitis (EAE).
Abourbeh, Galith +8 more
core +2 more sources
Automated radiosynthesis of Al[18F]PSMA-11 for large scale routine use. [PDF]
, 2018 Objectives: We report a reproducible automated radiosynthesis for large scale batch production of clinical grade Al[F-18]PSMA-11. Methods: A SynthraFCHOL module was optimized to synthesize Al[F-18]PSMA-11 by Al[F-18]-chelation.
Brans, Boudewijn +7 more
core +1 more source