Results 121 to 130 of about 88,244 (379)

[O-methyl-¹¹C]N-(4-(4-(3-Chloro-2-methoxyphenyl)-piperazin-1-yl)butyl)-1H-indole-2-carboxamide ([¹¹C]BAK4-51) Is an Efflux Transporter Substrate and Ineffective for PET Imaging of Brain D₃ Receptors in Rodents and Monkey

Molecules, 2018
Selective high-affinity antagonists for the dopamine D3 receptor (D3R) are sought for treating substance use disorders. Positron emission tomography (PET) with an effective D3R radioligand could be a useful tool for the development of such therapeutics ...
Jeih-San Liow, Cheryl L. Morse, Shuiyu Lu, Michael Frankland, George L. Tye, Sami S. Zoghbi, Robert L. Gladding, Anver B. Shaik, Robert B. Innis, Amy H. Newman, Victor W. Pike   +10 more
doaj   +1 more source

Synthesis and bioevaluation of 125 I-labeled gold nanorods [PDF]

, 2011
A novel technique is described for monitoring the in vivo behavior of gold nanorods (GNRs) using _-imaging. GNRs were radiolabeled using [ 125 I] sodium iodide in a simple and fast manner with high yield and without disturbing their optical properties ...
Agarwal, Ashish, Kotov, Nicholas A., Rajian, Justin R, Shao, Xia, Wang, Xueding   +4 more
core   +1 more source

A Chelate-Free Nano-Platform for Incorporation of Diagnostic and Therapeutic Isotopes

International Journal of Nanomedicine, 2020
Yaser H Gholami, 1– 4 Lee Josephson, 3 Eman A Akam, 5 Peter Caravan, 5 Moses Q Wilks, 3 Xiang-Zuo Pan, 3, 6 Richard Maschmeyer, 1 Aleksandra Kolnick, 3, 7 Georges El Fakhri, 3 Marc D Normandin, 3 Zdenka Kuncic, 1, 4, 8 Hushan Yuan 3 1The ...
Gholami YH, Josephson L, Akam EA, Caravan P, Wilks MQ, Pan XZ, Maschmeyer R, Kolnick A, El Fakhri G, Normandin MD, Kuncic Z, Yuan H   +11 more
doaj  

New amino bisphosphonate compound for skeletal imaging: Comparison study with methylenediphosphonic acid (MDP) and (1-hydroxyethane-1,1-diyl) diphosphonic acid (HEDP)

Nukleonika, 2016
A novel bisphosphonate derivative (1-aminoethane-1,1-diyl)diphosphonic acid (AEDP) has been prepared and successfully labeled with 99mTc at high labeling yields.
Assaad Thaer
doaj   +1 more source

Target-or-Clear Zirconium-89 Labeled Silica Nanoparticles for Enhanced Cancer-Directed Uptake in Melanoma: A Comparison of Radiolabeling Strategies.

Chemistry of Materials, 2017
Designing a nanomaterials platform with high target-to-background ratios has long been one of the major challenges in the field of nanomedicine. Here, we introduce a "target-or-clear" multifunctional nanoparticle platform that demonstrates high tumor ...
Feng Chen, K. Ma, Li Zhang, Brian Madajewski, P. Zanzonico, S. Sequeira, M. Gonen, Ulrich B Wiesner, M. Bradbury   +8 more
semanticscholar   +1 more source

Feasibility of establishing a veterinary marker to total residue in edible tissues with non-radiolabeled study using high-resolution mass spectrometry

, 2022
Tong Wei, Rose Huang, Hong Zuo, Cyrus Zarabadipour, Amanda Moore, Dietmar Hamel, Laura Letendre   +6 more
openalex   +1 more source

Understanding the in vivo Uptake Kinetics of a Phosphatidylethanolamine-binding Agent \u3csup\u3e99m\u3c/sup\u3eTc-Duramycin [PDF]

, 2012
Introduction 99mTc-Duramycin is a peptide-based molecular probe that binds specifically to phosphatidylethanolamine (PE). The goal was to characterize the kinetics of molecular interactions between 99mTc-Duramycin and the target tissue.
Audi, Said H., Capacete, Joseph, Fang, Wei, Li, Zhixin, Liu, Yu, Shu, Laura G., Zhao, Ming   +6 more
core   +1 more source

Targeting GRP78 and the Proteostasis Network to Break the Therapeutic Ceiling in Neuroendocrine Prostate Cancer

iNew Medicine, EarlyView.
ABSTRACT HSPA5 (also known as GRP78/BiP) is a master regulator of the endoplasmic reticulum (ER) stress response and a key node in the proteostasis network. In neuroendocrine prostate cancer (NEPC), an aggressive, therapy‐refractory lineage that emerges under pressure from androgen receptor (AR) directed therapies, GRP78 is upregulated and co‐opted to ...
Amos Olalekan Akinyemi, Md Rakibul Alam, Mithu Howlader, Mohammad Esfini Farahani, Lixiang Gu, Chun Li, Chripus Ngule, Kevin Fulp, Bolaji Owoyemi, Xinyi Wang, Samuel Nwadialo, Fatemeh Selani, Makumba Esoe, Obaleye Oluwafunminiyi, Zhiguo Li   +14 more
wiley   +1 more source

Synthesis of a prosthetic group for radiolabeling of Melanoma targeting peptide Re-CCMSH [abstract] [PDF]

, 2007
only availableThere is currently no cure for malignant melanoma and the best hope for a patient is early diagnosis and surgical excision. A promising approach to early cancer diagnosis is the use of radiolabeled peptides for tumor imaging. Dr.
Quinn, Thomas P. (Thomas Patrick), 1961-, Wolf, Mark, Zhang, Xiuli   +2 more
core  

Synthesis and pre-clinical evaluation of a [18F] fluoromethyl-tanaproget derivative for imaging of progesterone receptor expression [PDF]

, 2016
The estrogen receptor (ER) and progesterone receptor (PR) are over-expressed in ∼50% of breast cancer lesions, and used as biomarkers to stratify patients for endocrine therapy. Currently, immunohistochemical (IHC) assessment of these lesions from a core-
Aboagye, EO, Allott, L, Carroll, L, Kealey, S, Merchant, S, Miller, PW, Smith, G, Tittrea, V, Witney, TH   +8 more
core   +1 more source