Results 131 to 140 of about 87,481 (331)

One‐pot Base‐free Suzuki‐Miyaura [11C]Methylation: Kinetic and Mechanistic Insights

Chemistry – A European Journal, EarlyView.
A base‐free Suzuki–Miyaura [11C]methylation is achieved in a one‐pot process with [11C]CH3I on moderate yields. Electronic effects enable transmetallation without boronate activation, while kinetics and DFT show oxidative addition (heterolytic) as the rate‐limiting step.
Oscar Moreno, Imad Azzeggarh, Jason P. Holland, Albert D. Windhorst, Jordi Llop   +4 more
wiley   +1 more source

Approaches to Reducing Normal Tissue Radiation from Radiolabeled Antibodies

Pharmaceuticals
Radiolabeled antibodies are powerful tools for both imaging and therapy in the field of nuclear medicine. Radiolabeling methods that do not release radionuclides from parent antibodies are essential for radiolabeling antibodies, and practical ...
Hiroyuki Suzuki, Kento Kannaka, Tomoya Uehara   +2 more
doaj   +1 more source

Efficient [(18)F]AlF Radiolabeling of ZHER3:8698 Affibody Molecule for Imaging of HER3 Positive Tumors.

Bioconjugate chemistry, 2016
The human epidermal growth factor receptor 3 (HER3) is overexpressed in several cancers, being linked to a more resistant phenotype and hence leading to poor patient prognosis. Imaging HER3 is challenging owing to the modest receptor number (
Chiara Da Pieve, L. Allott, C. D. Martins, A. Vardon, Daniela M. Ciobota, Gabriela Kramer-Marek, Graham Smith   +6 more
semanticscholar   +1 more source

Synthesis and Evaluation of Fluorinated Peptidomimetics Enabling the Development of 18F‐Labeled Radioligands Targeting Muscarinic Acetylcholine Receptor Subtype M3

ChemMedChem, EarlyView.
Fluorinated peptidomimetics targeting muscarinic acetylcholine receptor subtype M3: Fluorinated peptidomimetic compounds based on a β‐alanine‐glycine scaffold, with lead compound 24 demonstrating high M3 selectivity and submicromolar potency. The first M3‐selective positron emission tomography radioligand, [18F]24, is synthesized and will be evaluated ...
Miguel A. Herrera‐Rueda, Maxwell A. Boateng, Melinda Wuest, Frederick G. West, Frank Wuest   +4 more
wiley   +1 more source

Optimized Solid Phase-Assisted Synthesis of Dendrons Applicable as Scaffolds for Radiolabeled Bioactive Multivalent Compounds Intended for Molecular Imaging

Molecules, 2014
Dendritic structures, being highly homogeneous and symmetric, represent ideal scaffolds for the multimerization of bioactive molecules and thus enable the synthesis of compounds of high valency which are e.g., applicable in radiolabeled form as ...
Gabriel Fischer, Björn Wängler, Carmen Wängler   +2 more
doaj   +1 more source

Impact of Multiple S‐Palmitoylation on Peptide Ionization and Fragmentation in Mass Spectrometry

Chemistry–Methods, EarlyView.
S‐palmitoylation is selectively introduced at potential modification sites of a model peptide. Modified peptides are then characterized by mass spectrometry, and the sites of modification are unambiguously identified. Lipidation, such as S‐palmitoylation, is an important, reversible post‐translational modification of proteins determining not only their
Elisa Badin, Carla Schmidt
wiley   +1 more source

Alcohol-Supported Cu-Mediated ¹⁸F-Fluorination of Iodonium Salts under “Minimalist” Conditions

Molecules, 2019
In the era of personalized precision medicine, positron emission tomography (PET) and related hybrid methods like PET/CT and PET/MRI gain recognition as indispensable tools of clinical diagnostics.
Victoriya V. Orlovskaya, Daniel J. Modemann, Olga F. Kuznetsova, Olga S. Fedorova, Elizaveta A. Urusova, Niklas Kolks, Bernd Neumaier, Raisa N. Krasikova, Boris D. Zlatopolskiy   +8 more
doaj   +1 more source

Radiolabeling of DOTA-like conjugated peptides with generator-produced 68Ga and using NaCl-based cationic elution method

Nature Protocols, 2016
Gallium-68 (68Ga) is a generator-produced radionuclide with a short half-life (t½ = 68 min) that is particularly well suited for molecular imaging by positron emission tomography (PET).
D. Mueller, W. Breeman, I. Klette, M. Gottschaldt, A. Odparlik, M. Baehre, Izabela Tworowska, M. Schultz   +7 more
semanticscholar   +1 more source

Reducing the Burden of Interaction Studies in Cancer Patients Using a Stable Isotopically Labeled Microtracer: A Proof‐of‐Concept Study with Alectinib

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional drug‐food interaction studies of oral anticancer agents have a high patient burden. A patient‐friendly alternative approach to studying food effects could be the use of stable isotopically labeled microtracers. A prospective, single‐center, open‐label, crossover, food effect study with the microtracer 2H6‐alectinib was conducted in patients
Ma Ida Mohmaed Ali, Lisa T. van der Heijden, Matthijs Tibben, Hilde Rosing, Raween Kalicharan, Gerrina Ruiter, Jos H. Beijnen, Hinke Huisman‐Siebinga, Alwin D. R. Huitema, Neeltje Steeghs   +9 more
wiley   +1 more source

Recent Trends in Bioorthogonal Click-Radiolabeling Reactions Using Fluorine-18

Molecules, 2013
The increasing application of positron emission tomography (PET) in nuclear medicine has stimulated the extensive development of a multitude of novel and versatile bioorthogonal conjugation techniques especially for the radiolabeling of biologically ...
Doreen Pietzsch, Constantin Mamat, Marc Pretze   +2 more
doaj   +1 more source