Results 91 to 100 of about 26,475 (236)

Integrated multi‐omics analysis of post‐translational modifications in head and neck squamous cell carcinoma: elucidating x‐ray and carbon ion irradiation effects

Precision Radiation Oncology, EarlyView.
This study underscores the critical role of PTMs in mediating cellular responses to X‐ray and Carbon ion irradiation radiotherapy in HNSCC. The integration of multi‐omics data provides insights into the molecular mechanisms underlying radiation‐induced changes, offering valuable clues for improving therapeutic outcomes and advancing precision medicine ...
Fan‐Tong Xia, Zhi‐Yun Liao, Si‐Qi Cai, Li‐Rong Zhou, Meng‐Qi Yang, Xin Zhang, Dan Li, Huan Zhang, Yun‐Chang Liu, Jie‐Ying Yang, Jia Jiang, Yi‐Hong Hu, Jiang‐Dong Sui, Ying Wang   +13 more
wiley   +1 more source

The efficacy of concurrent chemoradiotherapy with or without nimotuzumab in high‐risk patients with locally advanced head and neck squamous cell carcinoma post‐surgery: A real‐world study

Precision Radiation Oncology, EarlyView.
Figure 1 Patient selection flowchart. CCRT, concurrent chemoradiotherapy; NCCRT, nimotuzumab and concurrent chemoradiotherapy. Abstract Purpose Patients with locally advanced head and neck squamous cell carcinoma (LA‐HNSCC) harboring high‐risk pathological features after radical surgery face high recurrence rates.
Yuejia Zhou, Linting Zhang, Wenjuan Lai, Jingyun Tan, Jing Gao, Yajie Liu, Shubin Wang, Feng Peng, Gangling Tong   +8 more
wiley   +1 more source

Baicalein Sensitizes Radioresistant BT549 and MCF7‐R Breast Cancer Cells by Modulating Rac1 Signaling

Phytotherapy Research, EarlyView.
ABSTRACT Radioresistance remains a key barrier in breast cancer (BC) treatment. Baicalein, a flavonoid from Scutellaria baicalensis, has shown potential to enhance radiosensitivity. This study investigates its efficacy and mechanism in radioresistant BC models. Radioresistant BC cell models were established via fractionated irradiation and validated by
Zitong Zhao, Zhangyun Li, Quanzhou Peng, Shuqun Zhang   +3 more
wiley   +1 more source

Radioresistance of the Liposomal Membrane Permeability [PDF]

Journal of Radiation Research, 1978
The radiosensitivities of artificial and natural liposomes were investigated to clarify the mechanism of damage to biomembranes. Both liposomes were highly resistant to X-rays, SH-blocking agents, radiation protective agents, and these combinations in terms of leakage of K+ or glucose. The results mean that the membrane structure of lipids is resistant
openaire   +2 more sources

Regulating Lipid Metabolism in Cancer: The Therapeutic Potential of Traditional Chinese Medicine

Phytotherapy Research, EarlyView.
By regulating the reprogramming of lipid metabolism in tumor cells, TCM provides a novel strategy for antitumor therapy with reduced toxicity and enhanced efficacy. ABSTRACT Lipid metabolic reprogramming is a key feature of tumor cells to adapt to the microenvironment and plays an important role in tumor growth, invasion, and metastasis.
Yufeng Gao, Huiming Huang, Xuejiao Wei, Xiaoxue Wang, Wanying Xie, Xinyu Qiu, Fei Wang, Zhuguo Wang, Ruoxin Zhang, Yilin Cai, Changhai Qu, Zhongdong Hu   +11 more
wiley   +1 more source

Raw Data: tRF-17-877S6V2 Modulates Radioresistance via Direct Targeting of ENO1 in Colorectal Cancer

This dataset contains the comprehensive raw data and analysis files from our study investigating the role of tRF-17-877S6V2 in colorectal cancer (CRC) radioresistance.
liu, kaitai
core   +1 more source

Tumor suppressor miR-29c regulates radioresistance in lung cancer cells

, 2017
Radiotherapy is an important treatment option for non-small cell lung carcinoma patients. Despite the appropriate use of radiotherapy, radioresistance is a biological behavior of cancer cells that limits the efficacy of this treatment.
Elena Arechaga-Ocampo, Reynalda Roldan-Perez, Ali Flores-Perez, Oscar Angeles-Zaragoza, Raul Bonilla-Moreno, Nicolas Villegas-Sepulveda, Cesar Lopez-Camarillo, Omar Peña-Curiel, Juan A Gonzalez-Barrios, Claudia H Gonzalez-De la Rosa, Alejandro Garcia-Carranca, Luis A Herrera, Rosalva Rangel Corona, Oscar del Moral-Hernandez, Isidro X Perez-Añorve   +14 more
core   +1 more source

Long noncoding RNA PCAT7 confers radioresistance of esophageal squamous cell carcinoma by promoting GCLM-mediated anti-ferroptosis

Journal of Translational Medicine
Background Radiotherapy is one of the standard treatments for advanced esophageal squamous cell carcinoma (ESCC), but the prognosis remains poor due to radioresistance of tumor cells.
Yu Hao, Xixi Zhao, Xiaobo Shi, Junxiang Zhang, Xiaozhi Zhang, Yue Ke, Wei Guo, Xiangyun Ma, Xiaoxiao Liu, Yuchen Wang, Ruijuan Zhang, Xiaotan Wang, Hongbing Ma, Shupei Pan   +13 more
doaj   +1 more source

Cytoplasmic HMGB1 promotes and interacts with BECN1 through ZNF460 to induce autophagy and accelerate radioresistance in colorectal cancer cells

Frontiers in Immunology
Radioresistance results in relapse and treatment failure in locally advanced colorectal cancer (CRC) patients. HMGB1 is reportedly associated with radioresistance in esophageal squamous cell carcinoma and breast cancer.
Yuhui Han, Xiuxin Liu, Wenjiong Sheng, Ruixue Kuang, Yan Zhang, Xinyu Jia, A. M. Abd El-Aty, A. M. Abd El-Aty, Tao Hu, Bin Wang, Yanchao Ma   +10 more
doaj   +1 more source

YTHDF2 in hepatocellular carcinoma: Bridging m6A modification and cancer progression

VIEW, EarlyView.
Abstract YTH N6‐methyladenosine RNAbinding protein F2 (YTHDF2) is an N6‐methyladenosine (m6A) reader protein that mainly regulates the stability of methylated transcripts through mRNA decay. In the liver, YTHDF2 is involved in metabolic homeostasis, oxidative stress responses, and immune regulation.
Sijie Zang, Dongxue Ge, Wanqi Yang, Haobin Shen, Weihong Ge, Li Li, Dayu Chen, Jinglin Wang   +7 more
wiley   +1 more source